In order to analyze and explain the mechanism of the two small inhibitors （ADS-JI and ADS-J2） binding to HIV-1 gp41, a computational study is carried out to help identifying possible binding modes by docking these c...In order to analyze and explain the mechanism of the two small inhibitors （ADS-JI and ADS-J2） binding to HIV-1 gp41, a computational study is carried out to help identifying possible binding modes by docking these compounds onto the hydrophobic pocket on gp41 and characterize structures of binding complexes. The binding interactions of gp41-molecule and free energies of binding are obtained through molecular dynamics simulation and molecular mechanic/Poisson- Boitzmann surface area （ MM/PBSA ） calculation. Specific molecular interactions in the gp41-inhibitor complexes are identified. The present computational study complements the corresponding experimental investigation and helps establish a good starting point tbr further refinement of small molecular gp41 inhibitors.展开更多
Landscape ecology provides new theoretical frameworks and methodologies for understanding complex ecological phenomena at multiple scales.Studies of landscape ecology focus on understanding the dynamics of eco-logical...Landscape ecology provides new theoretical frameworks and methodologies for understanding complex ecological phenomena at multiple scales.Studies of landscape ecology focus on understanding the dynamics of eco-logical patterns and processes,and highlight the integration of multiple disciplines.In this paper,we discussed the problems and challenges that landscape ecology is currently facing,emphasizing the limitations of current methods used to describe dynamic landscape patterns and processes.We suggested that the focus should be on the integration of ground-based observation,mobile monitoring,transect survey,and remote-sensing monitoring,as well as improved coupling of experimental and model simulations.In addition,we outlined the research frontiers in landscape ecology,including scaling,integrated pattern and process modeling,and regional synthesis.Lastly,a brief review of pat-tern-process-scale coupling studies in China was provided.We concluded by pointing out that pattern-process-scale interactions,correlations between natural,economic,and social processes,and the coupling of human and natural systems will be major research areas in landscape ecology in the future.展开更多
The new ＂4-to-1＂ school-enterprise cooperation model is constructed in combination with the automation program provided by Tianshi College. The new school-enterprise cooperation model is an effective way for Tianshi...The new ＂4-to-1＂ school-enterprise cooperation model is constructed in combination with the automation program provided by Tianshi College. The new school-enterprise cooperation model is an effective way for Tianshi College to train high-quality skilled personnel, an important carrier to deepen the production-study-research cooperation education, and also an important part to improve the work quality of personnel cultivation. In China, it is an urgent need of the current employment situation, but also an important strategy for Tianshi College to attain a lon^-term stable develot^ment. In the orocess of imolementation, a win-win situation has been achieved bv constantly deenening reform.展开更多
Stationary entanglement in a four-mode optomechanical system,especially under room-temperature,is discussed.In this scheme,when the coupling strengths between the two target modes and the mechanical resonator are equa...Stationary entanglement in a four-mode optomechanical system,especially under room-temperature,is discussed.In this scheme,when the coupling strengths between the two target modes and the mechanical resonator are equal,the results cannot be explained by the Bogoliubov-mode-based scheme.This is related to the idea of quantummechanics-free subspace,which plays an important role when the thermal noise of the mechanical modes is considered.Significantly prominent steady-state entanglement can be available under room-temperature.展开更多
基金The National Basic Research Program of China (973 Program) (No. 2007CB936300)
文摘In order to analyze and explain the mechanism of the two small inhibitors （ADS-JI and ADS-J2） binding to HIV-1 gp41, a computational study is carried out to help identifying possible binding modes by docking these compounds onto the hydrophobic pocket on gp41 and characterize structures of binding complexes. The binding interactions of gp41-molecule and free energies of binding are obtained through molecular dynamics simulation and molecular mechanic/Poisson- Boitzmann surface area （ MM/PBSA ） calculation. Specific molecular interactions in the gp41-inhibitor complexes are identified. The present computational study complements the corresponding experimental investigation and helps establish a good starting point tbr further refinement of small molecular gp41 inhibitors.
基金Under the auspices of National Natural Science Foundation of China (No.40930528)State Forestry Administration of China (No.201004058)
文摘Landscape ecology provides new theoretical frameworks and methodologies for understanding complex ecological phenomena at multiple scales.Studies of landscape ecology focus on understanding the dynamics of eco-logical patterns and processes,and highlight the integration of multiple disciplines.In this paper,we discussed the problems and challenges that landscape ecology is currently facing,emphasizing the limitations of current methods used to describe dynamic landscape patterns and processes.We suggested that the focus should be on the integration of ground-based observation,mobile monitoring,transect survey,and remote-sensing monitoring,as well as improved coupling of experimental and model simulations.In addition,we outlined the research frontiers in landscape ecology,including scaling,integrated pattern and process modeling,and regional synthesis.Lastly,a brief review of pat-tern-process-scale coupling studies in China was provided.We concluded by pointing out that pattern-process-scale interactions,correlations between natural,economic,and social processes,and the coupling of human and natural systems will be major research areas in landscape ecology in the future.
文摘The new ＂4-to-1＂ school-enterprise cooperation model is constructed in combination with the automation program provided by Tianshi College. The new school-enterprise cooperation model is an effective way for Tianshi College to train high-quality skilled personnel, an important carrier to deepen the production-study-research cooperation education, and also an important part to improve the work quality of personnel cultivation. In China, it is an urgent need of the current employment situation, but also an important strategy for Tianshi College to attain a lon^-term stable develot^ment. In the orocess of imolementation, a win-win situation has been achieved bv constantly deenening reform.
基金Supported by National Natural Science Foundation of China under Grant No.11174109
文摘Stationary entanglement in a four-mode optomechanical system,especially under room-temperature,is discussed.In this scheme,when the coupling strengths between the two target modes and the mechanical resonator are equal,the results cannot be explained by the Bogoliubov-mode-based scheme.This is related to the idea of quantummechanics-free subspace,which plays an important role when the thermal noise of the mechanical modes is considered.Significantly prominent steady-state entanglement can be available under room-temperature.
