背景:不习惯的运动使骨骼肌损伤,但可以产生一种减轻肌肉再损伤减轻疼痛的特定训练效果-肌肉记忆。目的:基于延迟性肌肉酸痛的病因,综述延迟性肌肉酸痛中骨骼肌记忆的存在及其可能机制,提出防治延迟性肌肉酸痛的新见解。方法:第一作者以...背景:不习惯的运动使骨骼肌损伤,但可以产生一种减轻肌肉再损伤减轻疼痛的特定训练效果-肌肉记忆。目的:基于延迟性肌肉酸痛的病因,综述延迟性肌肉酸痛中骨骼肌记忆的存在及其可能机制,提出防治延迟性肌肉酸痛的新见解。方法:第一作者以“DOMS,Skeletal muscle memory,Exercise Skeletal muscle adaptation,Repeat turn effect,exercise and autophagy,Autophagy and inflammation”为英文检索词,“延迟性肌肉酸痛,骨骼肌记忆,运动性骨骼肌适应,重复回合效应,运动与自噬,自噬与炎症”为中文检索词,检索PubMed、Embase、Web of Science、中国知网及万方数据库1990年1月至2022年12月发表的相关文献,最终纳入102篇文献进行综述。结果与结论:目前认为延迟性肌肉酸痛是由于代谢紊乱、机械损伤和氧化应激所致的急性期炎症反应,而运动性骨骼肌记忆具有减轻延迟性肌肉酸痛、减轻运动再损伤的作用,当离心训练的持续时间、频率和强度逐渐增加时,损伤症状可以被最小化,甚至可以避免。因此基于运动性骨骼肌记忆机制,寻找防治或减轻延迟性肌肉酸痛及运动性肌肉损伤的方法是未来的研究方向。综述的主要目的:①明确运动性骨骼肌记忆的存在;②探讨运动性骨骼肌记忆的可能机制,并提出该记忆与骨骼肌自噬的关系;③通过改善骨骼肌自噬水平为延迟性肌肉酸痛的防治提供新策略。展开更多
Genome-wide association studies have firmly established that many genomic loci contribute to inflammatory bowel disease, especially in Crohn’s disease. These studies have newly-established the importance of the inter...Genome-wide association studies have firmly established that many genomic loci contribute to inflammatory bowel disease, especially in Crohn’s disease. These studies have newly-established the importance of the interleukin 23 and autophagy pathways in disease pathogenesis. Future challenges include: (1) the establishment of precisely causal alleles, (2) definition of altered functional outcomes of associated and causal alleles and (3) integration of genetic findings with environmental factors.展开更多
文摘背景:不习惯的运动使骨骼肌损伤,但可以产生一种减轻肌肉再损伤减轻疼痛的特定训练效果-肌肉记忆。目的:基于延迟性肌肉酸痛的病因,综述延迟性肌肉酸痛中骨骼肌记忆的存在及其可能机制,提出防治延迟性肌肉酸痛的新见解。方法:第一作者以“DOMS,Skeletal muscle memory,Exercise Skeletal muscle adaptation,Repeat turn effect,exercise and autophagy,Autophagy and inflammation”为英文检索词,“延迟性肌肉酸痛,骨骼肌记忆,运动性骨骼肌适应,重复回合效应,运动与自噬,自噬与炎症”为中文检索词,检索PubMed、Embase、Web of Science、中国知网及万方数据库1990年1月至2022年12月发表的相关文献,最终纳入102篇文献进行综述。结果与结论:目前认为延迟性肌肉酸痛是由于代谢紊乱、机械损伤和氧化应激所致的急性期炎症反应,而运动性骨骼肌记忆具有减轻延迟性肌肉酸痛、减轻运动再损伤的作用,当离心训练的持续时间、频率和强度逐渐增加时,损伤症状可以被最小化,甚至可以避免。因此基于运动性骨骼肌记忆机制,寻找防治或减轻延迟性肌肉酸痛及运动性肌肉损伤的方法是未来的研究方向。综述的主要目的:①明确运动性骨骼肌记忆的存在;②探讨运动性骨骼肌记忆的可能机制,并提出该记忆与骨骼肌自噬的关系;③通过改善骨骼肌自噬水平为延迟性肌肉酸痛的防治提供新策略。
文摘Genome-wide association studies have firmly established that many genomic loci contribute to inflammatory bowel disease, especially in Crohn’s disease. These studies have newly-established the importance of the interleukin 23 and autophagy pathways in disease pathogenesis. Future challenges include: (1) the establishment of precisely causal alleles, (2) definition of altered functional outcomes of associated and causal alleles and (3) integration of genetic findings with environmental factors.
