When checking the ice shape calculation software,its accuracy is judged based on the proximity between the calculated ice shape and the typical test ice shape.Therefore,determining the typical test ice shape becomes t...When checking the ice shape calculation software,its accuracy is judged based on the proximity between the calculated ice shape and the typical test ice shape.Therefore,determining the typical test ice shape becomes the key task of the icing wind tunnel tests.In the icing wind tunnel test of the tail wing model of a large amphibious aircraft,in order to obtain accurate typical test ice shape,the Romer Absolute Scanner is used to obtain the 3D point cloud data of the ice shape on the tail wing model.Then,the batch-learning self-organizing map(BLSOM)neural network is used to obtain the 2D average ice shape along the model direction based on the 3D point cloud data of the ice shape,while its tolerance band is calculated using the probabilistic statistical method.The results show that the combination of 2D average ice shape and its tolerance band can represent the 3D characteristics of the test ice shape effectively,which can be used as the typical test ice shape for comparative analysis with the calculated ice shape.展开更多
[ Objective] The aim of this study was to provide a theoretical basis for the prevention and treatment of highly pathogenic porcine reproductive and respiratory syndrome (HP-PRRS). [Method] Antigen location and hist...[ Objective] The aim of this study was to provide a theoretical basis for the prevention and treatment of highly pathogenic porcine reproductive and respiratory syndrome (HP-PRRS). [Method] Antigen location and histopathological observation in natural cases infected by highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) were analyzed by immunohistochemistry and H. E. staining. [Result] The virus antigen mainly existed in epithelial calls, and also a few in mecrophages, lymphocytes and brain nerve cells. [ Conclusion] The cell and tissue tropism of HP-PRRSV strain in natural cases is different from that of previous strains.展开更多
A methodology is presented whereby a neural network is used to learn the inverse kinematic relationships of the position and orientation of a six joint manipulator. The arm solution for the orientation of a manipulato...A methodology is presented whereby a neural network is used to learn the inverse kinematic relationships of the position and orientation of a six joint manipulator. The arm solution for the orientation of a manipulator using a self organizing neural net is studied in this paper. A new training model of the self organizing neural network is proposed by thoroughly studying Martinetz, Ritter and Schulten′s self organizing neural network based on Kohonen′s self organizing mapping algorithm using a Widrow Hoff type error correction rule and closely combining the characters of the inverse kinematic relationship for a robot arm. The computer simulation results for a PUMA 560 robot show that the proposed method has a significant improvement over other methods documented in the references in self organizing capability and precision by training process.展开更多
How to share experience and resources among learners is becoming one of the hottest topics in the field of E-Learning collaborative techniques. An intuitive way to achieve this objective is to group learners which can...How to share experience and resources among learners is becoming one of the hottest topics in the field of E-Learning collaborative techniques. An intuitive way to achieve this objective is to group learners which can help each other into the same community and help them learn collaboratively. In this paper, we proposed a novel community self-organization model based on multi-agent mechanism, which can automatically group learners with similar preferences and capabilities. In particular, we proposed award and exchange schemas with evaluation and preference track records to raise the performance of this algorithm. The description of learner capability, the matchmaking process, the definition of evaluation and preference track records, the rules of award and exchange schemas and the self-organization algorithm are all discussed in this paper. Meanwhile, a prototype has been built to verify the validity and efficiency of the algorithm. Experiments based on real learner data showed that this mechanism can organize learner communities properly and efficiently; and that it has sustainable improved efficiency and scalability.展开更多
Objective To investigate the efficacy of hematopoietic stem cell (HSC) transplantation via the hepatic artery vs. the portal vein for end-stage liver disease (ESLD). Methods Patients with hepatic decompensation w...Objective To investigate the efficacy of hematopoietic stem cell (HSC) transplantation via the hepatic artery vs. the portal vein for end-stage liver disease (ESLD). Methods Patients with hepatic decompensation were prospectively recruited from September 2010 to September 2012 to receive HSC transplantation via the hepatic artery or the portal vein. Liver function was examined at 3, 6, and 12 months after transplantation. Liver biopsy results were analyzed using the Knodell score. Results Eighty patients (58 males and 22 females) were enrolled in the study. The Child-Pugh score was grade B in 69 cases, and grade C in the remaining 11 cases. HSC transplantation was performed via the portal vein in 36 patients and via the hepatic artery in 44 patients. ALT levels decreased while serum albumin levels increased significantly in both groups at 6 and 12 months after HSC transplantation (P〈0.05 compared with pre-transplantation levels). Total biliruhin levels decreased significandy in both groups at 3, 6, and 12 months after HSC transplantation (P〈0.05 compared with pre-transplantation levels). Additionally, prothromhin time decreased in both groups at 12 months after HSC transplantation (P〈0.05 compared with pre-transplantation level). There were no significant differences in ALT, total bilirubin and prothromhin time between the two groups either before or after transplantation. Moreover, Knodell score decreased significantly at 6 and 12 months. Histological examination showed that liver cell edema, degeneration, necrosis, and inflammation were significantly relieved at 3, 6, and 12 months after transplantation. The incidence of portal vein thrombosis, upper gastrointestinal bleeding, and hepatic encephalopathy were 1.25%, 3.75%, and 2.5% respectively. The one-year survival rate was 100%. Conclusions Autologous HSC transplantation improves liver function and histology in ESLD patients The administration route of HSC has no significant impact on the efficacy of transplantation.展开更多
Nodular regenerative hyperplasia(NRH)is a rare liver condition characterized by a widespread benign transformation of the hepatic parenchyma into small regenerative nodules.NRH may lead to the development of non-cirrh...Nodular regenerative hyperplasia(NRH)is a rare liver condition characterized by a widespread benign transformation of the hepatic parenchyma into small regenerative nodules.NRH may lead to the development of non-cirrhotic portal hypertension.There are no published systematic population studies on NRH and our current knowledge is limited to case reports and case series.NRH may develop via autoimmune,hematological,infectious,neoplastic,or drug-related causes.The disease is usually asymptomatic,slowly or nonprogressive unless complications of portal hypertension develop.Accurate diagnosis is made by histopathology,which demonstrates diffuse micronodular transformation without fibrous septa.Lack of perinuclear collagen tissue distinguishes NRH from typical regenerative nodules in the cirrhotic liver.While the initial treatment is to address the underlying disease,ultimately the therapy is directed to the management of portal hypertension.The prognosis of NRH depends on both the severity of the underlying illness and the prevention of secondary complications of portal hypertension.In this review we detail the epidemiology,pathogenesis,diagnosis,management,and prognosis of NRH.展开更多
AIM: To evaluate the natural history of human cytomegalovirus (HCMV) infection in a series of 28 ulcerative colitis patients in whom the search for HCMV was positive. METHODS: A series of 85 patients with moderate...AIM: To evaluate the natural history of human cytomegalovirus (HCMV) infection in a series of 28 ulcerative colitis patients in whom the search for HCMV was positive. METHODS: A series of 85 patients with moderate-se- vere ulcerative colitis flare-up were evaluated for a HCMV search by performing a haematoxylin and eosin stain, immunohistochemical assay and nested polymerase chain reaction on rectal biopsies. Among 85 screened patients (19 of whom were steroid resistant/dependant), 28 were positive for HCMV; after remission the patients were followed up clinically and histologically. RESULTS: Among the 22 patients with complete follow- up, in 8 (36%) patients HCMV-DNA persisted in the in- testinal specimens. Among the HCMV positive patients, 4 (50%) experienced at least one moderate-severeflare-up of colitis without evidence of peripheral HCMV. Among the 14 HCHV negative patients, 3 with pouches developed pouchiUs and 5 out of 11 (45%) experienced a colitis flare-up. CONCLUSION: Our preliminary results suggest that HCHV may remain in the colon afber an acute coltis flare- up despite remission; it seems that the virus is not responsible for the disease relapse.展开更多
AIM: To study the sensitivity of gastric smooth muscle to C-type natriuretic peptide (CNP) in streptozotocin (STZ)-induced diabetic rats. METHODS: The spontaneous contraction of a gastric smooth muscle strip was recor...AIM: To study the sensitivity of gastric smooth muscle to C-type natriuretic peptide (CNP) in streptozotocin (STZ)-induced diabetic rats. METHODS: The spontaneous contraction of a gastric smooth muscle strip was recorded by using physiological methods in rats. The expressions of CNP and natriuretic peptide receptor-B (NPR-B) in gastric tissue were examined by using immunohistochemistry techniques in the diabetic rat. RESULTS: At 4 wk after injection of STZ and vehicle, the frequency of spontaneous contraction of gastric smooth muscle was significantly reduced in diabetic rats, and the frequency was decreased from 3.10 ± 0.14 cycle/min in controls to 2.23 ± 0.13 cycle/min (n = 8, P < 0.01). However, the amplitude of spontaneous contraction was not significant different from the normal rat. CNP significantly inhibited spontaneous contraction of gastric smooth muscle in normal and diabetic rats, but the inhibitory effect was significantly potentiated in the diabetic rats. The amplitudes of spontaneous contraction were suppressed by 75.15% ± 0.71% and 58.92% ± 1.32% while the frequencies were decreased by 53.33% ± 2.03% and 26.95% ± 2.82% in diabetic and normal rats, respectively (n = 8, P < 0.01). The expression of CNP in gastric tissue was not changed in diabetic rats, however the expression of NPR-B was significantly increased in diabetic rats, and the staining indexes of NPR-B were 30.67 ± 1.59 and 17.63 ± 1.49 in diabetic and normal rat, respectively (n = 8, P < 0.01).CONCLUSION: The results suggest that CNP induced an inhibitory effect on spontaneous contraction of gastric smooth muscle, potentiated in diabetic rat via up-regulation of the natriuretic peptides-NPR-B-particulate guanylyl cyclase-cyclic GMP signal pathway.展开更多
The author will propose that qualia--typically understood as the purely subjective and phenomenal elements of experience--are not specifically brain processes, but are instead best thought of as world processes that c...The author will propose that qualia--typically understood as the purely subjective and phenomenal elements of experience--are not specifically brain processes, but are instead best thought of as world processes that can be characterized as distributed self-organizing networks of Whiteheadian actual entities. If this is correct, then we need not wrestle with the materialist's "hard problem" of explaining how consciousness can arise from the purely objective particles and forces of fundamental ptiysics, but we will need to explain in what sense microparticles and other physical objects are experiential and objectively real without embracing panpsychism. Since Whiteheadian actual entities have intrinsic natures grounding the subjective and phenomenal aspects of experience, and extrinsic relations grounding objective physical properties, we find that qualia, understood in light of Whiteheadian actual entities, can provide the metaphysical foundations for both the subjective and objective aspects of the world.展开更多
AIM:To study the coincidence of celiac disease, we tested its serological markers in patients with various liver diseases.METHODS:Large-scale screening of serum antibodies against tissue transglutaminase (tTG), and de...AIM:To study the coincidence of celiac disease, we tested its serological markers in patients with various liver diseases.METHODS:Large-scale screening of serum antibodies against tissue transglutaminase (tTG), and deamidated gliadin using enzyme-linked immunosorbent assay and serum antibodies against endomysium using immunohistochemistry, in patients with various liver diseases (n = 962) and patients who underwent liver transplantation (OLTx, n = 523) was performed. The expression of tTG in liver tissue samples of patients simultaneously suffering from celiac disease and from various liver diseases using immunohistochemistry was carried out. The final diagnosis of celiac disease was confirmed by histological analysis of small-intestinal biopsy. RESULTS:We found that 29 of 962 patients (3%) with liver diseases and 5 of 523 patients (0.8%) who underwent OLTx were seropositive for IgA and IgG anti-tTG antibodies. However, celiac disease was biopsy-diagnosed in 16 patients:4 with autoimmune hepatitis type Ⅰ, 3 with Wilson's disease, 3 with celiac hepatitis, 2 with primary sclerosing cholangitis, 1 with primary biliary cirrhosis, 1 with Budd-Chiari syndrome, 1 with toxic hepatitis, and 1 with non-alcoholic steatohepatitis. Unexpectedly, the highest prevalence of celiac disease was found in patients with Wilson's disease (9.7%), with which it is only rarely associated. On the other hand, no OLTx patients were diagnosed with celiac disease in our study. A pilot study of the expression of tTG in liver tissue using immunohistochemistry documented the overexpression of this molecule in endothelial cells and periportal hepatocytes of patients simultaneously suffering from celiac disease and toxic hepatitis, primary sclerosing cholangitis or autoimmune hepatitis type Ⅰ. CONCLUSION:We suggest that screening for celiac disease may be beneficial not only in patients with associated liver diseases, but also in patients with Wilson's disease.展开更多
This letter proposes a categorization matrix to analyze the playing style of a computer game player for a shooting game genre. Our aim is to use human-centered modeling as a strategy for adaptive games based on entert...This letter proposes a categorization matrix to analyze the playing style of a computer game player for a shooting game genre. Our aim is to use human-centered modeling as a strategy for adaptive games based on entertainment measure to evaluate the playing experience. We utilized a self-organizing map (SOM) to cluster the player's style with the data obtained while playing the game. We further argued that style-based adaptation contributes to higher enjoyment, and this is reflected in our experiment using a supervised multilayered perceptron (MLP) network.展开更多
The morphologies of monolayers containing Eu(TTA)3Phen (TTA=thenoyltrifluoroace-tone, Phen = 1, 10-phenanthroline) were studied at the air/liquid interface on different subphases by fluorescence microscopy (FM). The c...The morphologies of monolayers containing Eu(TTA)3Phen (TTA=thenoyltrifluoroace-tone, Phen = 1, 10-phenanthroline) were studied at the air/liquid interface on different subphases by fluorescence microscopy (FM). The composite subphase was the basic premise for the stable existence of the rare earth compound at air/liquid interface. The process that rare earth compound phase changes from liquid expanded state to liquid condensed state corresponded to a plateau in the π-A isotherm. In the pure Eu(TTA)3Phen monolayer, rod domains of Eu(TTA)3Phen formed and packed with no order. In the mixed monolayers with stearic acid (SA), phase transition of SA occurred first and formed domains with an electric gradient field, which induced the rare earth compound to form luminescent ring domains. Influence of intermolecular interaction on the self-organized microstructure was revealed.展开更多
This paper describes a non-linear information dynamics model for integrated risk assessment of complex disaster system from an evolution perspective. According to the occurrence and evolution of natural disaster syste...This paper describes a non-linear information dynamics model for integrated risk assessment of complex disaster system from an evolution perspective. According to the occurrence and evolution of natural disaster system with complicated and nonlinear characteristics, a non-linear information dynamics mode is introduced based on the maximum flux principle during modeling process to study the integrated risk assessment of complex disaster system. Based on the non-equilibrium statistical mechanics method, a stochastic evolution equation of this system is established. The integrated risk assessment of complex disaster system can be achieved by giving reasonable weights of each evaluation index to stabilize the system. The new model reveals the formation pattern of risk grade and the dynamics law of evolution. Meanwhile, a method is developed to solve the dynamics evolution equations of complex system through the self-organization feature map algorithm. The proposed method has been used in complex disaster integrated risk assessment for 31 provinces, cities and autonomous regions in China mainland. The results have indicated that the model is objective and effective.展开更多
Bodies of plants are modularly organized. Development proceeds by adding new modules to open endings with a potential for branching. Each module is autonomous to some extent. Development relies on the self-organized p...Bodies of plants are modularly organized. Development proceeds by adding new modules to open endings with a potential for branching. Each module is autonomous to some extent. Development relies on the self-organized patterns that emerge from the interactions of individual modules. Interactions include both competition and cooperation,and several types of positive and negative feedback loops are involved. Development can be open to external influences, thus enabling the plant to adjust its form to the environment,for example, to the spatial distribution of ecological resources. This paper provides a review on adaptive plasticity in plants.展开更多
基金supported by the AG600 project of AVIC General Huanan Aircraft Industry Co.,Ltd.
文摘When checking the ice shape calculation software,its accuracy is judged based on the proximity between the calculated ice shape and the typical test ice shape.Therefore,determining the typical test ice shape becomes the key task of the icing wind tunnel tests.In the icing wind tunnel test of the tail wing model of a large amphibious aircraft,in order to obtain accurate typical test ice shape,the Romer Absolute Scanner is used to obtain the 3D point cloud data of the ice shape on the tail wing model.Then,the batch-learning self-organizing map(BLSOM)neural network is used to obtain the 2D average ice shape along the model direction based on the 3D point cloud data of the ice shape,while its tolerance band is calculated using the probabilistic statistical method.The results show that the combination of 2D average ice shape and its tolerance band can represent the 3D characteristics of the test ice shape effectively,which can be used as the typical test ice shape for comparative analysis with the calculated ice shape.
文摘[ Objective] The aim of this study was to provide a theoretical basis for the prevention and treatment of highly pathogenic porcine reproductive and respiratory syndrome (HP-PRRS). [Method] Antigen location and histopathological observation in natural cases infected by highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) were analyzed by immunohistochemistry and H. E. staining. [Result] The virus antigen mainly existed in epithelial calls, and also a few in mecrophages, lymphocytes and brain nerve cells. [ Conclusion] The cell and tissue tropism of HP-PRRSV strain in natural cases is different from that of previous strains.
文摘A methodology is presented whereby a neural network is used to learn the inverse kinematic relationships of the position and orientation of a six joint manipulator. The arm solution for the orientation of a manipulator using a self organizing neural net is studied in this paper. A new training model of the self organizing neural network is proposed by thoroughly studying Martinetz, Ritter and Schulten′s self organizing neural network based on Kohonen′s self organizing mapping algorithm using a Widrow Hoff type error correction rule and closely combining the characters of the inverse kinematic relationship for a robot arm. The computer simulation results for a PUMA 560 robot show that the proposed method has a significant improvement over other methods documented in the references in self organizing capability and precision by training process.
文摘How to share experience and resources among learners is becoming one of the hottest topics in the field of E-Learning collaborative techniques. An intuitive way to achieve this objective is to group learners which can help each other into the same community and help them learn collaboratively. In this paper, we proposed a novel community self-organization model based on multi-agent mechanism, which can automatically group learners with similar preferences and capabilities. In particular, we proposed award and exchange schemas with evaluation and preference track records to raise the performance of this algorithm. The description of learner capability, the matchmaking process, the definition of evaluation and preference track records, the rules of award and exchange schemas and the self-organization algorithm are all discussed in this paper. Meanwhile, a prototype has been built to verify the validity and efficiency of the algorithm. Experiments based on real learner data showed that this mechanism can organize learner communities properly and efficiently; and that it has sustainable improved efficiency and scalability.
基金Supported by the Science&Technology Department of Sichuan Province(2010FZ0098,2011HH0022)Chengdu Bureau of Science and Technology(10GGYB883SF)the Scientific Research Foundation of the Health Department of Sichuan Province(100487,100489)
文摘Objective To investigate the efficacy of hematopoietic stem cell (HSC) transplantation via the hepatic artery vs. the portal vein for end-stage liver disease (ESLD). Methods Patients with hepatic decompensation were prospectively recruited from September 2010 to September 2012 to receive HSC transplantation via the hepatic artery or the portal vein. Liver function was examined at 3, 6, and 12 months after transplantation. Liver biopsy results were analyzed using the Knodell score. Results Eighty patients (58 males and 22 females) were enrolled in the study. The Child-Pugh score was grade B in 69 cases, and grade C in the remaining 11 cases. HSC transplantation was performed via the portal vein in 36 patients and via the hepatic artery in 44 patients. ALT levels decreased while serum albumin levels increased significantly in both groups at 6 and 12 months after HSC transplantation (P〈0.05 compared with pre-transplantation levels). Total biliruhin levels decreased significandy in both groups at 3, 6, and 12 months after HSC transplantation (P〈0.05 compared with pre-transplantation levels). Additionally, prothromhin time decreased in both groups at 12 months after HSC transplantation (P〈0.05 compared with pre-transplantation level). There were no significant differences in ALT, total bilirubin and prothromhin time between the two groups either before or after transplantation. Moreover, Knodell score decreased significantly at 6 and 12 months. Histological examination showed that liver cell edema, degeneration, necrosis, and inflammation were significantly relieved at 3, 6, and 12 months after transplantation. The incidence of portal vein thrombosis, upper gastrointestinal bleeding, and hepatic encephalopathy were 1.25%, 3.75%, and 2.5% respectively. The one-year survival rate was 100%. Conclusions Autologous HSC transplantation improves liver function and histology in ESLD patients The administration route of HSC has no significant impact on the efficacy of transplantation.
文摘Nodular regenerative hyperplasia(NRH)is a rare liver condition characterized by a widespread benign transformation of the hepatic parenchyma into small regenerative nodules.NRH may lead to the development of non-cirrhotic portal hypertension.There are no published systematic population studies on NRH and our current knowledge is limited to case reports and case series.NRH may develop via autoimmune,hematological,infectious,neoplastic,or drug-related causes.The disease is usually asymptomatic,slowly or nonprogressive unless complications of portal hypertension develop.Accurate diagnosis is made by histopathology,which demonstrates diffuse micronodular transformation without fibrous septa.Lack of perinuclear collagen tissue distinguishes NRH from typical regenerative nodules in the cirrhotic liver.While the initial treatment is to address the underlying disease,ultimately the therapy is directed to the management of portal hypertension.The prognosis of NRH depends on both the severity of the underlying illness and the prevention of secondary complications of portal hypertension.In this review we detail the epidemiology,pathogenesis,diagnosis,management,and prognosis of NRH.
文摘AIM: To evaluate the natural history of human cytomegalovirus (HCMV) infection in a series of 28 ulcerative colitis patients in whom the search for HCMV was positive. METHODS: A series of 85 patients with moderate-se- vere ulcerative colitis flare-up were evaluated for a HCMV search by performing a haematoxylin and eosin stain, immunohistochemical assay and nested polymerase chain reaction on rectal biopsies. Among 85 screened patients (19 of whom were steroid resistant/dependant), 28 were positive for HCMV; after remission the patients were followed up clinically and histologically. RESULTS: Among the 22 patients with complete follow- up, in 8 (36%) patients HCMV-DNA persisted in the in- testinal specimens. Among the HCMV positive patients, 4 (50%) experienced at least one moderate-severeflare-up of colitis without evidence of peripheral HCMV. Among the 14 HCHV negative patients, 3 with pouches developed pouchiUs and 5 out of 11 (45%) experienced a colitis flare-up. CONCLUSION: Our preliminary results suggest that HCHV may remain in the colon afber an acute coltis flare- up despite remission; it seems that the virus is not responsible for the disease relapse.
基金Supported by The National Natural Science Foundation of China, No. 30760068
文摘AIM: To study the sensitivity of gastric smooth muscle to C-type natriuretic peptide (CNP) in streptozotocin (STZ)-induced diabetic rats. METHODS: The spontaneous contraction of a gastric smooth muscle strip was recorded by using physiological methods in rats. The expressions of CNP and natriuretic peptide receptor-B (NPR-B) in gastric tissue were examined by using immunohistochemistry techniques in the diabetic rat. RESULTS: At 4 wk after injection of STZ and vehicle, the frequency of spontaneous contraction of gastric smooth muscle was significantly reduced in diabetic rats, and the frequency was decreased from 3.10 ± 0.14 cycle/min in controls to 2.23 ± 0.13 cycle/min (n = 8, P < 0.01). However, the amplitude of spontaneous contraction was not significant different from the normal rat. CNP significantly inhibited spontaneous contraction of gastric smooth muscle in normal and diabetic rats, but the inhibitory effect was significantly potentiated in the diabetic rats. The amplitudes of spontaneous contraction were suppressed by 75.15% ± 0.71% and 58.92% ± 1.32% while the frequencies were decreased by 53.33% ± 2.03% and 26.95% ± 2.82% in diabetic and normal rats, respectively (n = 8, P < 0.01). The expression of CNP in gastric tissue was not changed in diabetic rats, however the expression of NPR-B was significantly increased in diabetic rats, and the staining indexes of NPR-B were 30.67 ± 1.59 and 17.63 ± 1.49 in diabetic and normal rat, respectively (n = 8, P < 0.01).CONCLUSION: The results suggest that CNP induced an inhibitory effect on spontaneous contraction of gastric smooth muscle, potentiated in diabetic rat via up-regulation of the natriuretic peptides-NPR-B-particulate guanylyl cyclase-cyclic GMP signal pathway.
文摘The author will propose that qualia--typically understood as the purely subjective and phenomenal elements of experience--are not specifically brain processes, but are instead best thought of as world processes that can be characterized as distributed self-organizing networks of Whiteheadian actual entities. If this is correct, then we need not wrestle with the materialist's "hard problem" of explaining how consciousness can arise from the purely objective particles and forces of fundamental ptiysics, but we will need to explain in what sense microparticles and other physical objects are experiential and objectively real without embracing panpsychism. Since Whiteheadian actual entities have intrinsic natures grounding the subjective and phenomenal aspects of experience, and extrinsic relations grounding objective physical properties, we find that qualia, understood in light of Whiteheadian actual entities, can provide the metaphysical foundations for both the subjective and objective aspects of the world.
基金Supported by Grant from the Czech Ministry of Health,No. NS9705-4/2008the Academy of Sciences of the Czech Republic, No. A500200709+1 种基金the Czech Science Foundation,No. 310/07/0414Institutional Research Concept Grant, No.AV0Z50200510 and No. RVO: 61388971
文摘AIM:To study the coincidence of celiac disease, we tested its serological markers in patients with various liver diseases.METHODS:Large-scale screening of serum antibodies against tissue transglutaminase (tTG), and deamidated gliadin using enzyme-linked immunosorbent assay and serum antibodies against endomysium using immunohistochemistry, in patients with various liver diseases (n = 962) and patients who underwent liver transplantation (OLTx, n = 523) was performed. The expression of tTG in liver tissue samples of patients simultaneously suffering from celiac disease and from various liver diseases using immunohistochemistry was carried out. The final diagnosis of celiac disease was confirmed by histological analysis of small-intestinal biopsy. RESULTS:We found that 29 of 962 patients (3%) with liver diseases and 5 of 523 patients (0.8%) who underwent OLTx were seropositive for IgA and IgG anti-tTG antibodies. However, celiac disease was biopsy-diagnosed in 16 patients:4 with autoimmune hepatitis type Ⅰ, 3 with Wilson's disease, 3 with celiac hepatitis, 2 with primary sclerosing cholangitis, 1 with primary biliary cirrhosis, 1 with Budd-Chiari syndrome, 1 with toxic hepatitis, and 1 with non-alcoholic steatohepatitis. Unexpectedly, the highest prevalence of celiac disease was found in patients with Wilson's disease (9.7%), with which it is only rarely associated. On the other hand, no OLTx patients were diagnosed with celiac disease in our study. A pilot study of the expression of tTG in liver tissue using immunohistochemistry documented the overexpression of this molecule in endothelial cells and periportal hepatocytes of patients simultaneously suffering from celiac disease and toxic hepatitis, primary sclerosing cholangitis or autoimmune hepatitis type Ⅰ. CONCLUSION:We suggest that screening for celiac disease may be beneficial not only in patients with associated liver diseases, but also in patients with Wilson's disease.
基金supported by the Soongsil University Research Fundthe Information Technology Research Center (ITRC) Support Program of the Ministry of Knowledge Economy (MKE), Korea
文摘This letter proposes a categorization matrix to analyze the playing style of a computer game player for a shooting game genre. Our aim is to use human-centered modeling as a strategy for adaptive games based on entertainment measure to evaluate the playing experience. We utilized a self-organizing map (SOM) to cluster the player's style with the data obtained while playing the game. We further argued that style-based adaptation contributes to higher enjoyment, and this is reflected in our experiment using a supervised multilayered perceptron (MLP) network.
基金the Award Foundation for Excellent Young Scientists in Shandong Province and the Climbing Program.
文摘The morphologies of monolayers containing Eu(TTA)3Phen (TTA=thenoyltrifluoroace-tone, Phen = 1, 10-phenanthroline) were studied at the air/liquid interface on different subphases by fluorescence microscopy (FM). The composite subphase was the basic premise for the stable existence of the rare earth compound at air/liquid interface. The process that rare earth compound phase changes from liquid expanded state to liquid condensed state corresponded to a plateau in the π-A isotherm. In the pure Eu(TTA)3Phen monolayer, rod domains of Eu(TTA)3Phen formed and packed with no order. In the mixed monolayers with stearic acid (SA), phase transition of SA occurred first and formed domains with an electric gradient field, which induced the rare earth compound to form luminescent ring domains. Influence of intermolecular interaction on the self-organized microstructure was revealed.
基金supported by the National Twelfth Five-year Technology Support Projects of China (Grant Nos. 2009BAJ28B04, 2011BAK07B01,2011BAJ08B03, and 2011BAJ08B05)the National Natural Science Foundation of China (Grant No. 51208017)+1 种基金Beijing Postdoctoral Research Foundation (Grant No. 2012ZZ-17)China Postdoctoral Science Foundation Funded Project (Grant No. 2011M500199)
文摘This paper describes a non-linear information dynamics model for integrated risk assessment of complex disaster system from an evolution perspective. According to the occurrence and evolution of natural disaster system with complicated and nonlinear characteristics, a non-linear information dynamics mode is introduced based on the maximum flux principle during modeling process to study the integrated risk assessment of complex disaster system. Based on the non-equilibrium statistical mechanics method, a stochastic evolution equation of this system is established. The integrated risk assessment of complex disaster system can be achieved by giving reasonable weights of each evaluation index to stabilize the system. The new model reveals the formation pattern of risk grade and the dynamics law of evolution. Meanwhile, a method is developed to solve the dynamics evolution equations of complex system through the self-organization feature map algorithm. The proposed method has been used in complex disaster integrated risk assessment for 31 provinces, cities and autonomous regions in China mainland. The results have indicated that the model is objective and effective.
基金This research was subsidized by the Hungarian National Research Fund(OTKA T35009,and NWOOTKA N34028),the Hungarian Ministry of Education(FKFP 0187/1990,Istvn Szchenyi Scolarship),and the International Program of the Santa Fe Institute,NM,USA.
文摘Bodies of plants are modularly organized. Development proceeds by adding new modules to open endings with a potential for branching. Each module is autonomous to some extent. Development relies on the self-organized patterns that emerge from the interactions of individual modules. Interactions include both competition and cooperation,and several types of positive and negative feedback loops are involved. Development can be open to external influences, thus enabling the plant to adjust its form to the environment,for example, to the spatial distribution of ecological resources. This paper provides a review on adaptive plasticity in plants.