Environmental sociology and the sociology of natural resources are two key subdisciplines of the sociological study on the interactions between nature and human society.Previous discussion on the relationships of thes...Environmental sociology and the sociology of natural resources are two key subdisciplines of the sociological study on the interactions between nature and human society.Previous discussion on the relationships of these two fields has largely focused on their distinctions and synthesis in western(particularly American) academia.Environmental sociology emerged as an important sociological subdiscipline in China in the early 1990s and is under vigorous disciplinary construction at present.By contrast,the sociology of natural resources is still a novel term for most Chinese researchers.This article provides a systematic review of recent literature on the relationships between environmental and natural resource sociologies,which should provide important implications for the further development of environmental sociology in China.展开更多
Community-based natural resource management in northeast India has a long history. Indigenous knowledge and adaptation are the collective information, with improvement from generation to generation. The expectation is...Community-based natural resource management in northeast India has a long history. Indigenous knowledge and adaptation are the collective information, with improvement from generation to generation. The expectation is that under community control, local expertise on biodiversity will play a significant role in natural resource management through traditional practices. This paper discusses the characteristics and application of the traditional ecological knowledge of aboriginal peoples in northeast India and its role in natural resource management. Examples are provided in two different eco-cultural landscapes, i.e., Demazong (the Buddhist eco-cultural landscape in Sikkim Himalaya) and the Apatani eco-cultural landscape in Arunachal Pradesh, which illustrate the utility value of traditional ecological knowledge in sustainable natural resource management. Both eco-cultural landscapes are indeed very complex and highly evolved systems with high levels of economic and ecological efficiencies. The paper concludes that traditional ecological knowledge systems and institutions could serve as entry points into the sustainable utilization and management of natural resources. This could be achieved through the exploration of the cultural practices of the local people and integrating useful aspects into the modern natural resource management expertise. With rapidly depleting biodiversity in the developing tropic regions, there is a greater utilization today than ever before of the value of respecting the "Sacred" as a tool towards better conservation of natural resources.展开更多
Natural and synthetic glucocorticoids (GCs) are widely employed in a number of inflammatory, autoimmune and neoplastic diseases, and, despite the introduction of novel therapies, remain the first-line treatment for in...Natural and synthetic glucocorticoids (GCs) are widely employed in a number of inflammatory, autoimmune and neoplastic diseases, and, despite the introduction of novel therapies, remain the first-line treatment for inducing remission in moderate to severe active Crohn’s disease and ulcerative colitis. Despite their extensive therapeutic use and the proven effectiveness, considerable clinical evidence of wide inter-individual differences in GC efficacy among patients has been reported, in particular when these agents are used in inflammatory diseases. In recent years, a detailed knowledge of the GC mechanism of action and of the genetic variants affecting GC activity at the molecular level has arisen from several studies. GCs interact with their cytoplasmic receptor, and are able to repress inflammatory gene expression through several distinct mechanisms. The glucocorticoid receptor (GR) is therefore crucial for the effects of these agents: mutations in the GR gene (NR3C1, nuclear receptor subfamily 3, group C, member 1) are the primary cause of a rare, inherited form of GC resistance; in addition, several polymorphisms of this gene have been described and associated with GC response and toxicity.However, the GR is not self-standing in the cell and the receptor-mediated functions are the result of a complex interplay of GR and many other cellular partners. The latter comprise several chaperonins of the large cooperative hetero-oligomeric complex that binds the hormonefree GR in the cytosol, and several factors involved in the transcriptional machinery and chromatin remodeling, that are critical for the hormonal control of target genes transcription in the nucleus. Furthermore, variants in the principal effectors of GCs (e.g. cytokines and their regulators) have also to be taken into account for a comprehensive evaluation of the variability in GC response. Polymorphisms in genes involved in the transport and/or metabolism of these hormones have also been suggested as other possible candidates of interest that could play a role in the observed inter-individual differences in efficacy and toxicity. The best-characterized example is the drug efflux pump P-glycoprotein, a membrane transporter that extrudes GCs from cells, thereby lowering their intracellular concentration. This protein is encoded by the ABCB1/ MDR1 gene; this gene presents different known polymorphic sites that can influence its expression and function. This editorial reviews the current knowledge on this topic and underlines the role of genetics in predicting GC clinical response. The ambitious goal of pharmacogenomic studies is to adapt therapies to a patient’s specific genetic background, thus improving on efficacy and safety rates.展开更多
The cartier that the natural tourism projects rely on should be the objective natural environments, including the mountains, water, animals and plants and so on, which are the object present before the development of ...The cartier that the natural tourism projects rely on should be the objective natural environments, including the mountains, water, animals and plants and so on, which are the object present before the development of the project. Therefore, what the natural tourism projects should first be ＂the economic value of the natural resources＂. However, after the man-made planning and being given the humanity, they have the ＂economic value of the human resources＂. In the construction of the future path of the development, we should also have the dynamic study on the subjective preferences of the Chinese consumers. The change of these subjective preferences directly results from the change of the levels of their own income.展开更多
文摘Environmental sociology and the sociology of natural resources are two key subdisciplines of the sociological study on the interactions between nature and human society.Previous discussion on the relationships of these two fields has largely focused on their distinctions and synthesis in western(particularly American) academia.Environmental sociology emerged as an important sociological subdiscipline in China in the early 1990s and is under vigorous disciplinary construction at present.By contrast,the sociology of natural resources is still a novel term for most Chinese researchers.This article provides a systematic review of recent literature on the relationships between environmental and natural resource sociologies,which should provide important implications for the further development of environmental sociology in China.
文摘Community-based natural resource management in northeast India has a long history. Indigenous knowledge and adaptation are the collective information, with improvement from generation to generation. The expectation is that under community control, local expertise on biodiversity will play a significant role in natural resource management through traditional practices. This paper discusses the characteristics and application of the traditional ecological knowledge of aboriginal peoples in northeast India and its role in natural resource management. Examples are provided in two different eco-cultural landscapes, i.e., Demazong (the Buddhist eco-cultural landscape in Sikkim Himalaya) and the Apatani eco-cultural landscape in Arunachal Pradesh, which illustrate the utility value of traditional ecological knowledge in sustainable natural resource management. Both eco-cultural landscapes are indeed very complex and highly evolved systems with high levels of economic and ecological efficiencies. The paper concludes that traditional ecological knowledge systems and institutions could serve as entry points into the sustainable utilization and management of natural resources. This could be achieved through the exploration of the cultural practices of the local people and integrating useful aspects into the modern natural resource management expertise. With rapidly depleting biodiversity in the developing tropic regions, there is a greater utilization today than ever before of the value of respecting the "Sacred" as a tool towards better conservation of natural resources.
文摘Natural and synthetic glucocorticoids (GCs) are widely employed in a number of inflammatory, autoimmune and neoplastic diseases, and, despite the introduction of novel therapies, remain the first-line treatment for inducing remission in moderate to severe active Crohn’s disease and ulcerative colitis. Despite their extensive therapeutic use and the proven effectiveness, considerable clinical evidence of wide inter-individual differences in GC efficacy among patients has been reported, in particular when these agents are used in inflammatory diseases. In recent years, a detailed knowledge of the GC mechanism of action and of the genetic variants affecting GC activity at the molecular level has arisen from several studies. GCs interact with their cytoplasmic receptor, and are able to repress inflammatory gene expression through several distinct mechanisms. The glucocorticoid receptor (GR) is therefore crucial for the effects of these agents: mutations in the GR gene (NR3C1, nuclear receptor subfamily 3, group C, member 1) are the primary cause of a rare, inherited form of GC resistance; in addition, several polymorphisms of this gene have been described and associated with GC response and toxicity.However, the GR is not self-standing in the cell and the receptor-mediated functions are the result of a complex interplay of GR and many other cellular partners. The latter comprise several chaperonins of the large cooperative hetero-oligomeric complex that binds the hormonefree GR in the cytosol, and several factors involved in the transcriptional machinery and chromatin remodeling, that are critical for the hormonal control of target genes transcription in the nucleus. Furthermore, variants in the principal effectors of GCs (e.g. cytokines and their regulators) have also to be taken into account for a comprehensive evaluation of the variability in GC response. Polymorphisms in genes involved in the transport and/or metabolism of these hormones have also been suggested as other possible candidates of interest that could play a role in the observed inter-individual differences in efficacy and toxicity. The best-characterized example is the drug efflux pump P-glycoprotein, a membrane transporter that extrudes GCs from cells, thereby lowering their intracellular concentration. This protein is encoded by the ABCB1/ MDR1 gene; this gene presents different known polymorphic sites that can influence its expression and function. This editorial reviews the current knowledge on this topic and underlines the role of genetics in predicting GC clinical response. The ambitious goal of pharmacogenomic studies is to adapt therapies to a patient’s specific genetic background, thus improving on efficacy and safety rates.
文摘The cartier that the natural tourism projects rely on should be the objective natural environments, including the mountains, water, animals and plants and so on, which are the object present before the development of the project. Therefore, what the natural tourism projects should first be ＂the economic value of the natural resources＂. However, after the man-made planning and being given the humanity, they have the ＂economic value of the human resources＂. In the construction of the future path of the development, we should also have the dynamic study on the subjective preferences of the Chinese consumers. The change of these subjective preferences directly results from the change of the levels of their own income.
