Microscopic colitis, comprising collagenous and lymphocytic colitis, is characterized clinically by chronic watery diarrhea, and a macroscopically normal colonic mucosa where diagnostic histopathological features are ...Microscopic colitis, comprising collagenous and lymphocytic colitis, is characterized clinically by chronic watery diarrhea, and a macroscopically normal colonic mucosa where diagnostic histopathological features are seen on microscoplc incidence of each disorder examination. The annual is 4-6/100000 inhabitants, with a peak incidence in 60-70-year-old individuals and a noticeable female predominance for collagenous colitis. The etiology is unknown. Chronic diarrhea, abdominal pain, weight loss, fatigue and fecal incontinence are common symptoms, which impair the health-related quality of life of the patient. There is an association with other autoimmune disorders such as celiac disease, diabetes mellitus, thyroid disorders and arthritis. Budesonide is the best-documented shortterm treatment, but the optimal long-term strategy needs further study. The long-term prognosis is good and the risk of complications including colonic cancer is low.展开更多
Celiac disease (CD) is an autoimmune disorder of the small intestine that occurs in genetically predisposed people at all ages.However,it can be associated also to other immunopathological disorders,and may be associa...Celiac disease (CD) is an autoimmune disorder of the small intestine that occurs in genetically predisposed people at all ages.However,it can be associated also to other immunopathological disorders,and may be associated with abnormal histology in segments of the gut other than the small bowel including colonic inflammation.While guidelines for endoscopic investigation of the jejunum are well defined,no indication is defined for colonic investigation.We describe four cases of concurrent CD and microscopic colitis (MC) diagnosed at our department over a 10-year period and analyzed the main features and outcomes of CD in this setting.The symptoms of these patients were improved initially by a gluten-free diet before the onset of MC symptoms.Two of the patients were siblings and had an atypical form of CD.The other two patients with CD and MC also presented with fibrosing alveolitis and were anti-Saccharomyces cerevisiae antibody positive.The co-existence of immune-mediated small bowel and colonic inflammatory and pulmonary diseases are not well-known,and no systematic approach has been used to identify the lifelong patterns of these immune-based diseases.Patients can develop,or present with CD at any stage in life,which can co-exist with other gastrointestinal diseases of (auto-) immune origin.In addition,the fa-milial co-existence and prevalence of MC in patients with a prior diagnosis of CD are unclear.Clinicians managing celiac disease should be aware of these associations and understand when to consider colon investigation.展开更多
The scalability of routing architectures for large networks is one of the biggest challenges that the Internet faces today.Greedy routing,in which each node is assigned a locator used as a distance metric,recently rec...The scalability of routing architectures for large networks is one of the biggest challenges that the Internet faces today.Greedy routing,in which each node is assigned a locator used as a distance metric,recently received increased attention from researchers and is considered as a potential solution for scalable routing.In this paper,LMD—a local minimum driven method is proposed to compute the topology-based locator.To eliminate the negative effect of the " quasi" greedy property—transfer routes longer than the shortest routes,a two-stage routing strategy is introduced,which combines the greedy routing with source routing.The greedy routing path discovered and compressed in the first stage is then used by the following source-routing stage.Through extensive evaluations,based on synthetic topologies as well as on a snapshot of the real Internet AS(autonomous system)topology,it is shown that LMD guarantees 100%delivery rate on large networks with low stretch.展开更多
基金Supported by Grants 16898-2005, 18293-2006 and 21142-2008 from the Swedish Society of Medicine (Bengt Ihre Foundation)rebro County Research Committee,and rebro University Hospital Research Foundation
文摘Microscopic colitis, comprising collagenous and lymphocytic colitis, is characterized clinically by chronic watery diarrhea, and a macroscopically normal colonic mucosa where diagnostic histopathological features are seen on microscoplc incidence of each disorder examination. The annual is 4-6/100000 inhabitants, with a peak incidence in 60-70-year-old individuals and a noticeable female predominance for collagenous colitis. The etiology is unknown. Chronic diarrhea, abdominal pain, weight loss, fatigue and fecal incontinence are common symptoms, which impair the health-related quality of life of the patient. There is an association with other autoimmune disorders such as celiac disease, diabetes mellitus, thyroid disorders and arthritis. Budesonide is the best-documented shortterm treatment, but the optimal long-term strategy needs further study. The long-term prognosis is good and the risk of complications including colonic cancer is low.
文摘Celiac disease (CD) is an autoimmune disorder of the small intestine that occurs in genetically predisposed people at all ages.However,it can be associated also to other immunopathological disorders,and may be associated with abnormal histology in segments of the gut other than the small bowel including colonic inflammation.While guidelines for endoscopic investigation of the jejunum are well defined,no indication is defined for colonic investigation.We describe four cases of concurrent CD and microscopic colitis (MC) diagnosed at our department over a 10-year period and analyzed the main features and outcomes of CD in this setting.The symptoms of these patients were improved initially by a gluten-free diet before the onset of MC symptoms.Two of the patients were siblings and had an atypical form of CD.The other two patients with CD and MC also presented with fibrosing alveolitis and were anti-Saccharomyces cerevisiae antibody positive.The co-existence of immune-mediated small bowel and colonic inflammatory and pulmonary diseases are not well-known,and no systematic approach has been used to identify the lifelong patterns of these immune-based diseases.Patients can develop,or present with CD at any stage in life,which can co-exist with other gastrointestinal diseases of (auto-) immune origin.In addition,the fa-milial co-existence and prevalence of MC in patients with a prior diagnosis of CD are unclear.Clinicians managing celiac disease should be aware of these associations and understand when to consider colon investigation.
基金Supported by the National High Technology Research and Development Program of China(No.2013AA013501)the National Program on Key Basic Research Project(No.2012CB315801)+1 种基金the National Natural Science Foundation of China(No.61133015)the Science and Technology on Information Transmission and Dissemination in Communication Networks Laboratory,CETC54
文摘The scalability of routing architectures for large networks is one of the biggest challenges that the Internet faces today.Greedy routing,in which each node is assigned a locator used as a distance metric,recently received increased attention from researchers and is considered as a potential solution for scalable routing.In this paper,LMD—a local minimum driven method is proposed to compute the topology-based locator.To eliminate the negative effect of the " quasi" greedy property—transfer routes longer than the shortest routes,a two-stage routing strategy is introduced,which combines the greedy routing with source routing.The greedy routing path discovered and compressed in the first stage is then used by the following source-routing stage.Through extensive evaluations,based on synthetic topologies as well as on a snapshot of the real Internet AS(autonomous system)topology,it is shown that LMD guarantees 100%delivery rate on large networks with low stretch.
