Proteasome-mediated degradation and autophagy are the two major pathways mediating the turnover of cellularproteins.The proteasomal pathway is known to be a highly specific and regulated process mediating the degradat...Proteasome-mediated degradation and autophagy are the two major pathways mediating the turnover of cellularproteins.The proteasomal pathway is known to be a highly specific and regulated process mediating the degradationof short-lived proteins such as many important factors involved in cellular signaling.In contrast,it is generally thoughtthat autophagy is rather nonselective as it is responsible for the bulk degradation of long-lived proteins and organelles.Challenging this general view,in this issue of Cell Research,Qing et al.report that selective degradation of the IκBkinase(IKK)triggered by the loss of Hsp90 function is mediated by autophagy[1].展开更多
文摘Proteasome-mediated degradation and autophagy are the two major pathways mediating the turnover of cellularproteins.The proteasomal pathway is known to be a highly specific and regulated process mediating the degradationof short-lived proteins such as many important factors involved in cellular signaling.In contrast,it is generally thoughtthat autophagy is rather nonselective as it is responsible for the bulk degradation of long-lived proteins and organelles.Challenging this general view,in this issue of Cell Research,Qing et al.report that selective degradation of the IκBkinase(IKK)triggered by the loss of Hsp90 function is mediated by autophagy[1].
