桂附理中丸中白术的薄层鉴别及乌头碱限量检查

目的 :对桂附理中丸中白术真伪进行鉴别及对乌头碱作限量检查。方法 :按《中国药典》(附录ⅥB)薄层色谱法进行。结果 :白术的薄层鉴别检测品与对照药材色谱相应位置上显相同颜色的荧光斑点 ,乌头碱限量检查的色谱中检测品斑点小于对照品斑点。结论 :所检样品中白术与标准样品相同 。

参苓白术散(丸)临床应用解析

药物组成人参100g，茯苓100g，白术（炒）100g，山药100g，白扁豆（炒）75g，莲子50g，薏苡仁（炒）50g，砂仁50g，桔梗50g，甘草100g。功能主治补脾胃，益肺气。用于脾胃虚弱，食少便溏，气短咳嗽，肢倦乏力。

参苓白术散加减治疗糖尿病性腹泻35例

随着糖尿病发病率的升高，糖尿病性腹泻已逐渐增多。糖尿病性腹泻是非感染性腹泻，是糖尿病并发症之一。糖尿病性腹泻的病因复杂，现代医学对其发病机制尚未明确，缺乏特效治疗。笔者应用参苓自术散加减治疗糖尿病性腹泻35例，取得了满意的疗效，现报告如下。

Linggui Zhugan Decoction Improves High Glucose-Induced Autophagy in Podocytes

Objective To explore the influence of Linggui Zhugan Decoction(LGZGD)on high glucose induced podocyte autophagy Methods LGZGD containing serum were prepared by intragastric administation of 4.2 g·kg^(-1)(low dose),8.4 g·kg^(-1)(medium dose),and 12.6 g·kg^(-1)(high dose)LGZGD into SD rats respectively.MPC5 and AB8/13 cells were treated with 60 mmol/L glucose to establish diabetic nephropathy podocyte model in vitro.Podocytes,MPC5 and AB8.13,were divided into control group,high glucose group,low dose LGZGD group,medium dose LGZGD group,and high dose LGZGD group,respectively.For the three LGZGD groups,before LGZGD intervention,podocytes were treated with 60 mmol/L glucose for 3 days.After treated with LGZGD containing serum,cells were collected to analyze cell migration using Transwell assay,proliferation using CCK8,apoptosis and cell cycle using flow cytometry,,autophagosome formation using transmission electron microscopy,and expression levels of Beclin-1,Atg5,LC3II/I,and P62 proteins using western blot.Results Compared with the control group,the proliferation and migration of MPC5 and AB8.13 cells in high glucose group showed slightly decreased,whereas these parameters restored after intervention with low and medium concentrations of LGZGD,with the medium dose LGZGD having the best effect.Flow cytometry analysis showed that the medium dose LGZGD group had a lower apoptosis rate(P<0.05)and higher survival rate(P>0.05)compared to the high dose group.High glucose arrested podocytes in G1 phase,whereas LGZGD shifted podocytes from being predominant in G1 phase to increasing into G2.High dose LGZGD significanly reduced increased autophagosome formation due to high glucose in both podocytes(P<0.05).Western blot analysis showed that Beclin-1,Atg5,LC3Ⅱ/Ⅰ,and P62 expressions were increased in MPC5 cells treated with high glucose,and reversed after adminstration of low and medium doses of LGZGD(P<0.05).Conclusion LGZGD reduced apoptosis and enhanced autophagy in high glucose treated podocytes via regulating Beclin-1/LC3II/I/Atg5 expression.

Enabling Technologies for Autonomous Robotic Systems in Manufacturing

Research of autonomous manufacturing systems is motivated both by the new technical possibilities of cyber-physical systems and by the practical needs of the industry.Autonomous operation in semi-structured industrial environments can now be supported by advanced sensor technologies,digital twins,artificial intelligence and novel communication techniques.These enable real-time monitoring of production processes,situation recognition and prediction,automated and adaptive(re)planning,teamwork and performance improvement by learning.This paper summarizes the main requirements towards autonomous industrial robotics and suggests a generic workflow for realizing such systems.Application case studies will be presented from recent practice at HUN-REN SZTAKI in a broad range of domains such as assembly,welding,grinding,picking and placing,and machining.The various solutions have in common that they use a generic digital twin concept as their core.After making general recommendations for realizing autonomous robotic solutions in the industry,open issues for future research will be discussed.

考虑滑面材质的碎屑流试验堆积特征分析

为分析高速远程滑坡运动与堆积特征,在室内设置物理试验模型,设计级配、坡角、碎屑流质量、滑面材质4种因素,分析各因素对碎屑流堆积特征的影响。研究结果表明:坡角减小、滑面更粗糙使部分颗粒堆积或滞留于坡面,颗粒堆积特征与颗粒完全堆积于坡底时相比存在差异;滑面材质与冲程等堆积特征基本呈负相关,坡角与堆积特征基本呈正相关,二者对堆积特征影响最大;碎屑流质量与堆积特征基本呈负相关,对颗粒堆积特征分布影响较小;级配与颗粒堆积特征无明显相关性。

电力电工专家恽震自述(一)

恽震（１９０１．１０．１４－１９９４．１．１４）先生是中国电机工程和机电工业的先驱。他参加了国家的标准制订、学术组织和电工产业的创办、技术引进、技术人才培养等重要活动，并做出了重要贡献。该自述（一）讲述了恽震１９４４年８月之前的主要经历。

Drain and Source on Insulator MOSFETs Fabricated by Local SIMOX Technology

To overcome the floating-body effect and self-heating effect of SOI devices,the drain and source on insulator (DSOI) structure is fabricated and tested.The low dose developed recently and low energy local SIMOX technology combined with the conventional CMOS technology is used to fabricate this kind of devices.Using this method,DSOI,SOI,and bulk MOSFETs are successfully integrated on a single chip.Test results show that the drain induced barrier lowering effect is suppressed.The breakdown voltage drain-to-source is greatly increased for DSOI devices due to the elimination of the floating-body effect.And the self-heating effect is also reduced and thus the reliability increased.At the same time,the advantage of SOI devices in speed is maintained.The technology makes it possible to integrate low voltage,low power,low speed SOI devices or high voltage,high power,high speed DSOI devices on one chip and it offers option for developing system-on-chip technology.

Ultra-precision alignment technique based on modified Moiré signals

A novel method for automatic ultra-precision alignment is presented.This method relies on the modified Moiré technique,and alignment marks are used in the form of gratings.The modified Moiré technique can effectively improve detecting sensitivity of signals and simplify the control system by using only one pair of laser-Moiré sensors.We present the mathematical model and simulation results of diffracting two gratings.The effect of various parameters on Moiré signals is studied theoretically and experimentally,and the results are found to be consistent.A computer controlled alignment device using one pair of Moiré sensors is designed.The device can achieve a fully automatic precision alignment by the modified Moiré signal.The experimental result shows that the alignment device can obtain the resolution of 5 nm and the positioning accuracy of ±0 5 μm.

MATHEMATICAL MODEL OF SELF-REPAIRING FLIGHT CONTROL

The most prospective method for certain structural failures and damages that cannot employ redundancy is self-repairing techniques, to ensure especially the maximum flight safety. Based on the characters of self-repairing aircraft, this paper states some basic assumptions of the self-repairing aircraft, and puts forward some special new conceptions concerning the self-repairing aircraft: control input, operating input, command input, repair input and operating and control factor as well as their relationships. Thus it provides a simple and reliable mathematical model structure for the research on the self-repairing control of the aircraft.

慢性腹泻的治疗体会

目的:观察黄连素、参苓白术散、补中益气丸对慢性腹泻的治疗效果。方法:将61例本病患者随机分为两组,治疗组31例,采用黄连素、参苓白术散、补中益气丸治疗;对照组30例。采用氟哌酸或环丙沙星、并结合临床给予对症支持治疗。结果:治疗组有效率100%,对照组有效率66.6%,两组临床疗效比较差异显著(Ρ<0.01),治疗组明显优于对照组。结论:黄连素、参苓白术散,补中益气丸治疗慢性腹泻疗效显著。

A Comparative Study on the Quality Components Between Self Pollinated Seeds and Naturally Pollinated Seeds in Brassica napus L. in Sichuan Ecological Region

[ Objective] This study was to reveal the differences in crude fat and glucosinolates between self pollinated seeds and naturally pollinated seeds in Brassica napus in sichuan ecological region.. [ Method] Near-infrared spectroscopy method （NIRS） was employed to measure the quality components in self pollinated seeds and naturally pollinated seeds of 861 shares of Brassica napus from Sichuan ecological region. And correlation analysis and regression analysis were conducted based on the experimental data via SPSS （statistics package for social science）. [ Result] The contents of crude fat in the self pollinated seeds were commonly a higher than that in the naturally pollinated seeds at 0.01 significant level; while the contents of glucosinolates in the self pollinated seeds and the naturally pollinated seeds were insignificantly different. Both the correlation relationship and linear regression for the crude fat between the self pollinated seeds and naturally pollinated seeds reached the significant level. The regression equations for the contents of crude fat（y1 ） and glucosinolates（ y2 ） in the naturally pollinated seeds and of crude fat（ x1 ） and glucosinolates（ x2 ） in self pollinated seeds were respectively determined to be y1 = 16.844 ＋0.614x1 and y2 = -0.620 ＋ 1.017 x2. [ Conclusion] In Brassica napus breeding, crude fat in naturally pollinated seeds should be emphatically taken into account, meanwhile concurrently considering that in self pollinated seeds; while glucosinolates in both the self pollinated seeds and the naturally pollinated seeds must be simultaneously concerned.

中西医结合治疗儿童慢性鼻窦炎45例总结

目的 :观察中西医结合治疗儿童慢性鼻窦炎的临床疗效。方法 :将 90例随机分为治疗组和对照组各 4 5例 ,分别以中西医结合和单纯西医治疗 ,记录其症状、体征及影像学变化。结果 :治疗组总有效率为 88.9% ,对照组总有效率为 71 .1 % ,两组总有效率比较 ,有显著性差异 (P <0 .0 5 )。结论 :中西医结合治疗儿童慢性鼻窦炎疗效确切 。

Shelf-cultivation of Strawberry with Mulch and Heat Preservation Technology with Natural Energy

It is proved that the treatment with white mulch and black thin films per- formed the best in terms of heat preservation in cultivation of strawberry with shelves. In winter, drip irrigation performed significantly in transporting hot water through solar energy. The combination of the two methods resolved the issue of heat preservation difficulty and guaranteed growth of strawberry in winter.

1.5μm Self-Aligned Spotsize Converter Integrated DFB Fabricated by Selective Area Grown MOVPE

High performance 1 57μm spotsize converter monolithically integrated DFB is fabricated by the technique of self aligned selective area growth.The upper optical confinement layer and the butt coupled tapered thickness waveguide are regrown simultaneously,which not only offeres the separated optimization of the active region and the integrated spotsize converter,but also reduces the difficulty of the butt joint selective regrowth.The threshold current is as low as 4 4mA.The output power at 49mA is 10 1mW.The side mode suppression ratio (SMSR) is 33 2dB.The vertical and horizontal far field divergence angles are as small as 9° and 15° respectively,the 1dB misalignment tolerance are 3 6μm and 3 4μm.

Analysis of Amylase and Superoxide Dismutase Isozymes During the Germination Process of Emmenopterys henryi Oliv Seeds

[ Objective] The study was to understand the changes of amylase（AMY） and superoxide dismutase（SOD） isozymes during the ger- mination process of Emmenopterys henryi Oliv seeds. [ Metbod] By employing polyacrylamide gel electrophoresis method, the expressions of AMY and SOD isozymes during seed germination process were analyzed. ~ Result] The main AMY bands remained strong during the whole peri- od and a new band A2 appeared in the middle and late period of seed germination. Some new SOD bands occurred at the early stage, then be- came weak or disappeared in the middle period, and band S6 became intense in the late peried. [ Conclusion.] The expression of AMY and SOD isozyme gene has temporal difference during germination of E. henryi Oliv seeds.

Investigation of Thermal Property of Novel DSOI MOSFETs Fabricated with Local SIMOX Technique

DSOI,bulk Si and SOI MOSFETs are fabricated on the same die successfully using local oxygen implantation process.The thermal properties of the three kinds of devices are described and compared from simulation and measurement.Both simulation and measurement prove that DSOI MOSFETs have the advantage of much lower thermal resistance of substrate and suffer less severe self heating effect than their SOI counterparts. At the same time,the electrical advantages of SOI devices can stay.The thermal resistance of DSOI devices is very close to that of bulk devices and DSOI devices can keep this advantage into deep sub micron realm.

Liver Resection for Spontaneous Rupture of Primary Hepatocellular Carcinoma

Objective To study the effect of liver resection for spontaneous rupture of primary hepatocellulal carcinoma (PHCC). Methods The clinical data of 12 patients with ruptured PHCC treated by liver resection in Xiangya Hospital since 1970 were analyzed retrospectively. Results There were 10 males and 2 females with mean age of 42 (ranged 22–65) years in this series. Of the 12 patients, 11 underwent emergent hepatectomy and one 2-stage hepatectomy, including left segmental liver resection in 6 patients, left median lobectomy in 1, left hemihepatectomy in 1, partial right hepatectomy in 2, and tumor resection in 2. There was no operative death in 11 patients with liver function in grade A of Child-Paugh classification, but 1 patient with grade B liver function died of liver failure after operation. The operative mortality was 8.3%. In 11 survived patients, the postoperative median survival time was 16.5 months. The 1?, 3?, 5-year survival rate was 72.7%, 18.2%, 9.1% respectively; among them one patient has been alive free of the tumor for 25 years and 9 months. Conclusion Liver resection is the best treatment for ruptured PHCC when possible, which can result in long survival time. Key words liver resection - spontaneous ruptare - primary hepatocellular carcinoma

Mismatch Calibration Techniques in Successive Approximation Analog-to-Digital Converters

Comparator offset cancellation and capacitor self-calibration techniques used in a successive approximation analog-to-digital converter （SA-ADC） are described. The calibration circuit works in parallel with the SAADC by adding additional calibration clock cycles to pursue high accuracy and low power consumption, and the calibrated resolution can be up to 14bit. This circuit is used in a 10bit 3Msps successive approximation ADC. This chip is realized with an SMIC 0. 18μm 1.8V process and occupies 0.25mm^2 . It consumes 3. 1mW when operating at 1.8MHz. The measured SINAD is 55. 9068dB, SFDR is 64. 5767dB, and THD is - 74. 8889dB when sampling a 320kHz sine wave.