The inflammation which follows cryotherapy is a significant disadvantage of th is therapeutic modality. To date, the only treatment shown to reduce this inflam mation is application of topical corticoids. We have ther...The inflammation which follows cryotherapy is a significant disadvantage of th is therapeutic modality. To date, the only treatment shown to reduce this inflam mation is application of topical corticoids. We have therefore conducted a pilot study to investigate whether pretreatment with the free radical scavengers, vit amins C and E might alleviate the signs and symptoms of inflammation following l iquid nitrogen cryotherapy of common warts. We undertook a randomized, double-b lind, placebo-controlled, parallel group study. We recruited 40 adult patients, of whom 38 returned for evaluation. Treatments comprised vitamin C (2000 mg) an d vitamin E (800 IU) daily or matching placebo for 7 days prior to cryotherapy t o a hand wart. Oedema volume, erythema level, pain intensity and the presence or absence of blistering were assessed 24 h after cryotherapy. There were no signi ficant differences between the two treatment groups in any of the parameters ass essed. This study yielded no suggestion of benefit from the use of pretreatment with free radical scavengers in conjunction with liquid nitrogen cryotherapy.展开更多
文摘The inflammation which follows cryotherapy is a significant disadvantage of th is therapeutic modality. To date, the only treatment shown to reduce this inflam mation is application of topical corticoids. We have therefore conducted a pilot study to investigate whether pretreatment with the free radical scavengers, vit amins C and E might alleviate the signs and symptoms of inflammation following l iquid nitrogen cryotherapy of common warts. We undertook a randomized, double-b lind, placebo-controlled, parallel group study. We recruited 40 adult patients, of whom 38 returned for evaluation. Treatments comprised vitamin C (2000 mg) an d vitamin E (800 IU) daily or matching placebo for 7 days prior to cryotherapy t o a hand wart. Oedema volume, erythema level, pain intensity and the presence or absence of blistering were assessed 24 h after cryotherapy. There were no signi ficant differences between the two treatment groups in any of the parameters ass essed. This study yielded no suggestion of benefit from the use of pretreatment with free radical scavengers in conjunction with liquid nitrogen cryotherapy.
