We describe a case of a 33-year-old female patient with chronic hepatitis B who developed type 1 diabetes mellitus (DM) after a 13-mo period of treatment with recombinant human interferon-alpha (IFN-α) 2b. The patien...We describe a case of a 33-year-old female patient with chronic hepatitis B who developed type 1 diabetes mellitus (DM) after a 13-mo period of treatment with recombinant human interferon-alpha (IFN-α) 2b. The patient presented with polydipsia, polyuria, hypergly-cemia, diabetic ketoacidosis, combined with C-peptide secretion defi ciency and positive islet cell autoantibody (ICAb). IFN-α 2b treatment was terminated and in-stead insulin treatment was initiated. Five months after cessation of the recombinant human IFN-α 2b therapy, the patient remained insulin-dependent. Her serum HBV DNA became negative and serum transaminase returned to the normal level after a 10-mo period of IFN therapy. Type 1 DM induced by IFN-α is relatively rare in patients with chronic hepatitis B. We should pay more attention to patients on IFN-α therapy to avoid destruction of pancreatic beta cells. This is the first case report from China.展开更多
INTRODUCTION： Latent autoimmune diabetes in adults （LADA） is regarded as one of the Insulin-de- pendent diabetes mellitus that progress slowly. It gradually became understood since 1970s. The on- set usually appear...INTRODUCTION： Latent autoimmune diabetes in adults （LADA） is regarded as one of the Insulin-de- pendent diabetes mellitus that progress slowly. It gradually became understood since 1970s. The on- set usually appears in adulthood, the islet autoanti- bodies are positive and the function of 13 cell is de- clined rapidly. The treatment is insulin injection. CASE PRESENTATION： The case reported followed is a 37-year-old male patient who was newly diag- nosed with type 2 diabetes. He abandoned oral hy- poglycemic agents since they caused stomach in- disposed. Before visiting, his islet autoantibodies were detected positive and he had never injected insulin before. We treated him with traditional Chi- nese herbals under the guidance of Traditional Chi- nese Medicine and differentiation, and achieved fine efficacy. CONCLUSION： Because the initial presentation of LADA is similar to Type 2 Diabetes Mellitus and ex- amination is not in common use, misdiagnosis isnot rare. Once LADA is diagnosed, the therapy must be adjusted. This case report indicated that Traditional Chinese Medicine might be an alterna- tive treatment for LADA.展开更多
文摘We describe a case of a 33-year-old female patient with chronic hepatitis B who developed type 1 diabetes mellitus (DM) after a 13-mo period of treatment with recombinant human interferon-alpha (IFN-α) 2b. The patient presented with polydipsia, polyuria, hypergly-cemia, diabetic ketoacidosis, combined with C-peptide secretion defi ciency and positive islet cell autoantibody (ICAb). IFN-α 2b treatment was terminated and in-stead insulin treatment was initiated. Five months after cessation of the recombinant human IFN-α 2b therapy, the patient remained insulin-dependent. Her serum HBV DNA became negative and serum transaminase returned to the normal level after a 10-mo period of IFN therapy. Type 1 DM induced by IFN-α is relatively rare in patients with chronic hepatitis B. We should pay more attention to patients on IFN-α therapy to avoid destruction of pancreatic beta cells. This is the first case report from China.
基金Supported by the National Basic Research Program of China(973 Program,No.2010CB530600)
文摘INTRODUCTION： Latent autoimmune diabetes in adults （LADA） is regarded as one of the Insulin-de- pendent diabetes mellitus that progress slowly. It gradually became understood since 1970s. The on- set usually appears in adulthood, the islet autoanti- bodies are positive and the function of 13 cell is de- clined rapidly. The treatment is insulin injection. CASE PRESENTATION： The case reported followed is a 37-year-old male patient who was newly diag- nosed with type 2 diabetes. He abandoned oral hy- poglycemic agents since they caused stomach in- disposed. Before visiting, his islet autoantibodies were detected positive and he had never injected insulin before. We treated him with traditional Chi- nese herbals under the guidance of Traditional Chi- nese Medicine and differentiation, and achieved fine efficacy. CONCLUSION： Because the initial presentation of LADA is similar to Type 2 Diabetes Mellitus and ex- amination is not in common use, misdiagnosis isnot rare. Once LADA is diagnosed, the therapy must be adjusted. This case report indicated that Traditional Chinese Medicine might be an alterna- tive treatment for LADA.
