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雌激素受体在自身免疫性甲状腺炎中的表达 被引量:5
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作者 王贵生 赵金凤 《中国误诊学杂志》 CAS 2008年第10期2298-2299,共2页
目的:探讨雌激素受体(ER)在自身免疫性甲状腺炎(AIT)中表达的情况。方法:采用PSA免疫组织化学方法检测80例自身免疫性甲状腺炎中ER的阳性表达率。结果:ER在AIT中的表达率为10%(+++)、21.25%(++)、23.75%(+),总阳性率为55%;而对照组总阳... 目的:探讨雌激素受体(ER)在自身免疫性甲状腺炎(AIT)中表达的情况。方法:采用PSA免疫组织化学方法检测80例自身免疫性甲状腺炎中ER的阳性表达率。结果:ER在AIT中的表达率为10%(+++)、21.25%(++)、23.75%(+),总阳性率为55%;而对照组总阳性率为10%,低于试验组(P<0.05)。结论:雌激素受体在AIT的发生中起一定的作用,可能对其今后治疗能起到一定的启示作用。 展开更多
关键词 甲状腺炎 自身免疫性/代谢 受体 雌激素/代谢 人类
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Consequences of dysthyroidism on the digestive tract and viscera 被引量:9
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作者 Ronald Daher Thierry Yazbeck +1 位作者 Joe Bou Jaoude Bassam Abboud 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第23期2834-2838,共5页
Thyroid hormones def ine basal metabolism throughout the body, particularly in the intestine and viscera. Gastrointestinal manifestations of dysthyroidism are numerous and involve all portions of the tract. Thyroid ho... Thyroid hormones def ine basal metabolism throughout the body, particularly in the intestine and viscera. Gastrointestinal manifestations of dysthyroidism are numerous and involve all portions of the tract. Thyroid hormone action on motility has been widely studied, but more complex pathophysiologic mechanisms have been indicated by some studies although these are not fully understood. Both thyroid hormone excess and def iciency can have similar digestive manifestations, such as diarrhea, although the mechanism is different in each situation. The liver is the most affected organ in both hypo-and hyperthyroidism. Specifi c digestive diseases may be associated with autoimmune thyroid processes, such as Hashimoto's thyroiditis and Grave's disease. Among them, celiac sprue and primary biliary cirrhosis are the most frequent although a clear common mechanism has never been proven. Overall, thyroid-related digestive manifestations were described decades ago but studies are still needed in order to conf irm old concepts or elucidate undiscovered mechanisms. All practitioners must be aware of digestive symptoms due to dysthyroidism in order to avoid misdiagnosis of rare but potentially lethal situations. 展开更多
关键词 HYPOTHYROIDISM HYPERTHYROIDISM Gastroin-testinal motility INTESTINE Liver VISCERA
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An update on primary ovarian insufficiency 被引量:23
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作者 JIN Min YU YiQi HUANG HeFeng 《Science China(Life Sciences)》 SCIE CAS 2012年第8期677-686,共10页
Primary ovarian insufficiency(POI) occurs in about 1% of female population under the age of 40,leading to reproductive problems,an earlier encounter with menopausal symptoms,and complicated diseases.There are three pr... Primary ovarian insufficiency(POI) occurs in about 1% of female population under the age of 40,leading to reproductive problems,an earlier encounter with menopausal symptoms,and complicated diseases.There are three presumable mechanisms involved in the development of POI,namely apoptosis acceleration,follicular maturation blocking and premature follicle activation,through the following studied causes:(i) chromosomal abnormalities or gene mutations:mostly involve X chromosome,such as FMR1 premutation;more and more potentially causal genes have been screened recently;(ii) metabolic disorders such as classic galactosaemia and 17-OH deficiency;(iii) autoimmune mediated ovarian damage:observed alone or with some certain autoimmune disorders and syndromes;but the specificity and sensitivity of antibodies towards ovary are still questionable;(iv) iatrogenic:radiotherapy or chemotherapy used in cancer treatment,as well as pelvic surgery with potential threat to ovaries' blood supply can directly damage ovarian function;(v) virus infection such as HIV and mumps;(vi) toxins and other environmental/lifestyle factors:cigarette smoking,toxins(e.g.,4-vinylcyclohexene diepoxide),and other environmental factors are associated with the development of POI.The etiology of a majority of POI cases is not identified,and is believed to be multifactorial.Strategies to POI include hormone replacement and infertility treatment.Assisted conception with donated oocytes has been proven to achieve pregnancy in POI women.Embryo cryopreservation,ovarian tissue cryopreservation and oocyte cryopreservation have been used to preserve ovarian reserve in women undergoing cancer treatments. 展开更多
关键词 primary ovarian insufficiency genetic aberrations environmental factors hormone replacement therapy ovary preservation
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