We have studied nocturnal movements using wrist-worn accelerometers in 33 adu lts with a range of pruritic dermatoses, 30 adult control subjects,25 children w ith atopic dermatitis,and 17 pediatric control subjects. I...We have studied nocturnal movements using wrist-worn accelerometers in 33 adu lts with a range of pruritic dermatoses, 30 adult control subjects,25 children w ith atopic dermatitis,and 17 pediatric control subjects. In all, 26 adults and 2 0 children were studied on more than one occasion, up to a maximum of 6 occasion s. Participants were examined and a range of subjective measures about the exten t of skin disease, itch, and quality of sleep were recorded. We show clear diffe rences between patients and control subjects for both age groups studied, with a ctivity medians approximately twice as high in the patients as in the control su bjects (P < . 001). Studies on the same person show a considerable night-to-ni ght variation that is unlikely to relate to measurement error, but instead, we b elieve, reflect genuine differences in nocturnal activity (and perhaps disease s everity). Movement through the night did not seem to follow any obvious pattern. The relation between subjective measures, Severity sCORing of Atopic Dermatitis (SCORAD)index scores, and objective recorded activity was imperfect, with much unaccounted for variation. In particular, in adults, but not in children, we fou nd a negative correlation (-0.44, P <. 02) between objective movement activity and self-reported quality of sleep. Our results support the use of objective me asures of scratch in the assessment of disease activity,andsuggest that the rela tion between subjective and objective measures of disease severity may not be st raightforward.展开更多
文摘We have studied nocturnal movements using wrist-worn accelerometers in 33 adu lts with a range of pruritic dermatoses, 30 adult control subjects,25 children w ith atopic dermatitis,and 17 pediatric control subjects. In all, 26 adults and 2 0 children were studied on more than one occasion, up to a maximum of 6 occasion s. Participants were examined and a range of subjective measures about the exten t of skin disease, itch, and quality of sleep were recorded. We show clear diffe rences between patients and control subjects for both age groups studied, with a ctivity medians approximately twice as high in the patients as in the control su bjects (P < . 001). Studies on the same person show a considerable night-to-ni ght variation that is unlikely to relate to measurement error, but instead, we b elieve, reflect genuine differences in nocturnal activity (and perhaps disease s everity). Movement through the night did not seem to follow any obvious pattern. The relation between subjective measures, Severity sCORing of Atopic Dermatitis (SCORAD)index scores, and objective recorded activity was imperfect, with much unaccounted for variation. In particular, in adults, but not in children, we fou nd a negative correlation (-0.44, P <. 02) between objective movement activity and self-reported quality of sleep. Our results support the use of objective me asures of scratch in the assessment of disease activity,andsuggest that the rela tion between subjective and objective measures of disease severity may not be st raightforward.
