调节性T细胞(regulatory T cells,Treg)在自身免疫性皮肤病的发生发展中起着关键作用,Treg细胞数量减少、功能缺失、相关细胞因子表达异常均与银屑病、系统性红斑狼疮、特应性皮炎等自身免疫性皮肤病密切相关。单味中药、中药单体化合...调节性T细胞(regulatory T cells,Treg)在自身免疫性皮肤病的发生发展中起着关键作用,Treg细胞数量减少、功能缺失、相关细胞因子表达异常均与银屑病、系统性红斑狼疮、特应性皮炎等自身免疫性皮肤病密切相关。单味中药、中药单体化合物、中药复方制剂均可调控Treg细胞防治自身免疫性皮肤病,临床疗效显著且安全性较高,主要作用机制为上调Treg细胞数量,增强抑制能力,促进免疫稳态恢复;升高Treg细胞转录因子的表达水平,调控Treg细胞分化;增加IL-10、IL-35等Treg细胞分泌的相关细胞因子的表达,减轻炎症反应。目前,中医药干预研究以内治法为主,有待加强中医外治法干预的研究,且中医药干预Treg细胞多为调节细胞数量、细胞因子及转录因子等,亟需明确其具体作用机制及信号传导通路,为中医药临床治疗此类难治性、复杂性皮肤病提供理论依据。展开更多
Background: No data are available on the incidence and immunoreactivity of autoimmune subepidermal blistering skin diseases in East Africa. Methods: All patients with frank blisters/erosions on the skin and/or mucous ...Background: No data are available on the incidence and immunoreactivity of autoimmune subepidermal blistering skin diseases in East Africa. Methods: All patients with frank blisters/erosions on the skin and/or mucous membranes that attended the Department of Dermatology at Mbarara University, Uganda, from May 2000 to June 2002, were investigated. The diagnosis was based on the clinical presentation and on the presence of circulating autoantibodies detected by indirect immunofluorescence microscopy on 1M NaCl-split human skin and by Western blotting of recombinant and cell-derived forms of BP180, BP230, and type VII collagen. Results: Twenty two patients with autoimmune subepidermal blistering skin disorders were identified, including nine with bullous pemphigoid pemphigoid(41%), four with linear immunoglobulin A (IgA) disease (18%), three with mucous membrane pemphigoid (14%), two with linear IgG/IgA bullous dermatosis (9%), and one each with cicatricial pemphigoid and epidermolysis bullosa acquisita (5%). In addition, two patients with immunoreactivity to both the epidermal and dermal side of salt-split skin by indirect immunofluorescence microscopy, who were unreactive to type VII collagen, were provisionally diagnosed as “mixed pemphigoid”(9%). In patients with subepidermal blistering diseases, IgG reactivity correlated significantly with old age, whereas younger patients preferentially developed IgA autoantibodies (P = 0.024). Conclusions: The age of patients with autoimmune subepidermal blistering diseases appears to influence the immunoglobulin class of autoantibodies. The high frequency of IgA autoantibodies in Ugandan patients may be explained by the age distribution of the Ugandan population.展开更多
文摘调节性T细胞(regulatory T cells,Treg)在自身免疫性皮肤病的发生发展中起着关键作用,Treg细胞数量减少、功能缺失、相关细胞因子表达异常均与银屑病、系统性红斑狼疮、特应性皮炎等自身免疫性皮肤病密切相关。单味中药、中药单体化合物、中药复方制剂均可调控Treg细胞防治自身免疫性皮肤病,临床疗效显著且安全性较高,主要作用机制为上调Treg细胞数量,增强抑制能力,促进免疫稳态恢复;升高Treg细胞转录因子的表达水平,调控Treg细胞分化;增加IL-10、IL-35等Treg细胞分泌的相关细胞因子的表达,减轻炎症反应。目前,中医药干预研究以内治法为主,有待加强中医外治法干预的研究,且中医药干预Treg细胞多为调节细胞数量、细胞因子及转录因子等,亟需明确其具体作用机制及信号传导通路,为中医药临床治疗此类难治性、复杂性皮肤病提供理论依据。
文摘Background: No data are available on the incidence and immunoreactivity of autoimmune subepidermal blistering skin diseases in East Africa. Methods: All patients with frank blisters/erosions on the skin and/or mucous membranes that attended the Department of Dermatology at Mbarara University, Uganda, from May 2000 to June 2002, were investigated. The diagnosis was based on the clinical presentation and on the presence of circulating autoantibodies detected by indirect immunofluorescence microscopy on 1M NaCl-split human skin and by Western blotting of recombinant and cell-derived forms of BP180, BP230, and type VII collagen. Results: Twenty two patients with autoimmune subepidermal blistering skin disorders were identified, including nine with bullous pemphigoid pemphigoid(41%), four with linear immunoglobulin A (IgA) disease (18%), three with mucous membrane pemphigoid (14%), two with linear IgG/IgA bullous dermatosis (9%), and one each with cicatricial pemphigoid and epidermolysis bullosa acquisita (5%). In addition, two patients with immunoreactivity to both the epidermal and dermal side of salt-split skin by indirect immunofluorescence microscopy, who were unreactive to type VII collagen, were provisionally diagnosed as “mixed pemphigoid”(9%). In patients with subepidermal blistering diseases, IgG reactivity correlated significantly with old age, whereas younger patients preferentially developed IgA autoantibodies (P = 0.024). Conclusions: The age of patients with autoimmune subepidermal blistering diseases appears to influence the immunoglobulin class of autoantibodies. The high frequency of IgA autoantibodies in Ugandan patients may be explained by the age distribution of the Ugandan population.
