目的探讨有创机械通气病死率预测评分(Invasive Mechanical Ventilation Mortality Prediction Score,IMPRES)对重症医学科(Intensive Care Units,ICU)有创机械通气患者是否受益的预测价值,并与急性生理与慢性健康评分Ⅱ(Acute Physiolo...目的探讨有创机械通气病死率预测评分(Invasive Mechanical Ventilation Mortality Prediction Score,IMPRES)对重症医学科(Intensive Care Units,ICU)有创机械通气患者是否受益的预测价值,并与急性生理与慢性健康评分Ⅱ(Acute Physiology and Chronic Health EvaluationⅡ,APACHEⅡ)、牛津急性疾病严重程度评分(Oxford Acute Severity of Illness Score,OASIS)比较。方法回顾性分析2018年3月—2019年12月收入我院ICU行有创机械通气患者的临床资料,按转归分为获益组(经治疗好转转科或出院)和非获益组(治疗无效死亡),利用受试者工作特征曲线下面积(Area under the Receiver Operating Characteristic curve,AUC)比较三种评分对ICU有创机械通气患者是否受益的预测价值。结果103例患者被纳入研究,男63例(61.17%),女40例(38.83%),获益组68例和非获益组35例。IMPRES评分的AUC为0.850(95%可信区间:0.765~0.934,P<0.001),评分4.75时Youden指数最大,为0.556,敏感性0.600,特异性0.956。APACHEⅡ评分的AUC为0.682(95%可信区间:0.570~0.795,P=0.003),评分22.5时Youden指数最大,为0.361,敏感性0.743,特异性0.618。OASIS评分的AUC为0.710(95%可信区间:0.602~0.818,P=0.001),评分26.5时Youden指数最大,为0.330,敏感性0.771,特异性0.559。IMPRES评分的AUC高于APACHEⅡ评分(Z=2.531,P=0.011)和OASIS评分(Z=2.117,P=0.034),差异有统计学意义。APACHEⅡ评分和OASIS评分的AUC比较差异无统计学意义(Z=0.316,P=0.752)。IMPRES评分<2分、2.1分~5分、5.1分~8分、>8分时,分别有8.00%、23.64%、92.86%、77.78%的患者不能获益。结论IMPRES评分≥5.1分时,患者从有创机械通气获益的机会可能会减少,有待前瞻性大样本研究进一步证实。展开更多
Cerebrospinal fluid (CSF) hypocretin-1 deficiency is associated with definite (“clear cut”) cataplexy in patients with narcolepsy. The relationship between CSF hypocretin-1 levels and other narcoleptic symptoms (inc...Cerebrospinal fluid (CSF) hypocretin-1 deficiency is associated with definite (“clear cut”) cataplexy in patients with narcolepsy. The relationship between CSF hypocretin-1 levels and other narcoleptic symptoms (including excessive daytime sleepiness, EDS) is not properly understood. In a consecutive series of 18 subjects with narcolepsy and definite cataplexy, patients with undetectable CSF hypocretin-1 (n = 12) were found to have significantly lower mean sleep latencies (p = 0.045) and a higher frequency of sleep onset REM periods (SOREMPs, p = 0.025) on multiple sleep latency test than patients (n = 6) with detectable levels. Conversely, Epworth sleepiness scale scores, the frequency of hallucinations /sleep paralysis, and the frequency and severity of cataplexy were similar in both groups. These results suggest that hypocretin deficiency identifies a homogenous group of patients with narcolepsy characterised by the presence of definite cataplexy, severe EDS, and frequent SOREMPs.展开更多
文摘目的探讨有创机械通气病死率预测评分(Invasive Mechanical Ventilation Mortality Prediction Score,IMPRES)对重症医学科(Intensive Care Units,ICU)有创机械通气患者是否受益的预测价值,并与急性生理与慢性健康评分Ⅱ(Acute Physiology and Chronic Health EvaluationⅡ,APACHEⅡ)、牛津急性疾病严重程度评分(Oxford Acute Severity of Illness Score,OASIS)比较。方法回顾性分析2018年3月—2019年12月收入我院ICU行有创机械通气患者的临床资料,按转归分为获益组(经治疗好转转科或出院)和非获益组(治疗无效死亡),利用受试者工作特征曲线下面积(Area under the Receiver Operating Characteristic curve,AUC)比较三种评分对ICU有创机械通气患者是否受益的预测价值。结果103例患者被纳入研究,男63例(61.17%),女40例(38.83%),获益组68例和非获益组35例。IMPRES评分的AUC为0.850(95%可信区间:0.765~0.934,P<0.001),评分4.75时Youden指数最大,为0.556,敏感性0.600,特异性0.956。APACHEⅡ评分的AUC为0.682(95%可信区间:0.570~0.795,P=0.003),评分22.5时Youden指数最大,为0.361,敏感性0.743,特异性0.618。OASIS评分的AUC为0.710(95%可信区间:0.602~0.818,P=0.001),评分26.5时Youden指数最大,为0.330,敏感性0.771,特异性0.559。IMPRES评分的AUC高于APACHEⅡ评分(Z=2.531,P=0.011)和OASIS评分(Z=2.117,P=0.034),差异有统计学意义。APACHEⅡ评分和OASIS评分的AUC比较差异无统计学意义(Z=0.316,P=0.752)。IMPRES评分<2分、2.1分~5分、5.1分~8分、>8分时,分别有8.00%、23.64%、92.86%、77.78%的患者不能获益。结论IMPRES评分≥5.1分时,患者从有创机械通气获益的机会可能会减少,有待前瞻性大样本研究进一步证实。
文摘Cerebrospinal fluid (CSF) hypocretin-1 deficiency is associated with definite (“clear cut”) cataplexy in patients with narcolepsy. The relationship between CSF hypocretin-1 levels and other narcoleptic symptoms (including excessive daytime sleepiness, EDS) is not properly understood. In a consecutive series of 18 subjects with narcolepsy and definite cataplexy, patients with undetectable CSF hypocretin-1 (n = 12) were found to have significantly lower mean sleep latencies (p = 0.045) and a higher frequency of sleep onset REM periods (SOREMPs, p = 0.025) on multiple sleep latency test than patients (n = 6) with detectable levels. Conversely, Epworth sleepiness scale scores, the frequency of hallucinations /sleep paralysis, and the frequency and severity of cataplexy were similar in both groups. These results suggest that hypocretin deficiency identifies a homogenous group of patients with narcolepsy characterised by the presence of definite cataplexy, severe EDS, and frequent SOREMPs.
