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普通变异型免疫缺陷病并发自身免疫相关疾病的临床特征与转归
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作者 徐浩杰 王璐 +1 位作者 陈蓓迪 赵丽丹 《中华临床免疫和变态反应杂志》 CAS 2021年第3期305-311,共7页
目的探讨普通变异型免疫缺陷病(common variable immunodeficiency,CVID)并发自身免疫相关疾病(autoimmune disorder,AD)的临床特征与疾病转归。方法回顾性分析1999年4月至2020年10月于北京协和医院住院的CVID患者94例,其中符合AD诊断... 目的探讨普通变异型免疫缺陷病(common variable immunodeficiency,CVID)并发自身免疫相关疾病(autoimmune disorder,AD)的临床特征与疾病转归。方法回顾性分析1999年4月至2020年10月于北京协和医院住院的CVID患者94例,其中符合AD诊断的患者(CVID-AD)22例,比较其与72例未并发AD的CVID患者(CVID-nAD)在临床表现、免疫学及转归的差异。结果CVID-AD组中,男12例,女10例。诊断CVID的中位年龄为25.5(4~51)岁,诊断AD的中位年龄为25(4~51)岁,AD多发生于CVID之前,81.8%患者CVID和AD同期诊断。AD类型多样,包括反应性关节炎3例(13.6%),炎症性肠病3例(13.6%),幼年型慢性关节炎、免疫性血小板减少性紫癜和自身免疫性溶血性贫血2例(9.1%),以及系统性红斑狼疮、成人Still病、复发性多软骨炎、肠道血管炎、贝赫切特病、重症肌无力、白癜风、银屑病关节炎、自身炎症性疾病、未分化结缔组织病各1例(4.5%)。CVID-AD组支气管扩张、肝损伤、皮肤感染、肝脾及淋巴结肿大等临床表现患者比例显著高于CVID-nAD组(P均<0.02)。结论CVID患者并发AD并非罕见,且可出现多种类型的AD表现,从而增加临床治疗难度和预后的不确定性,早期诊断、规范静脉用人免疫球蛋白治疗,有助于改善患者预后,激素和/或免疫抑制剂远期获益未明,应慎重使用于伴有内脏受累的AD患者。 展开更多
关键词 普通变异型免疫缺陷病 自身免疫相关疾病 临床特征 转归
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STAT3蛋白调节Th17细胞的分化及其与自身免疫相关性血液疾病的关系 被引量:7
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作者 柯杨 程韵枫 《中国临床医学》 2016年第5期662-666,共5页
信号转导和转录激活因子(signal transducer and activator of transcription,STAT)主要参与细胞信号转导。其中,STAT3蛋白在辅助性T细胞17(T helper cell 17,Th17细胞)的分化中起重要的作用。STAT3信号通路的异常也被证实与多种自身免... 信号转导和转录激活因子(signal transducer and activator of transcription,STAT)主要参与细胞信号转导。其中,STAT3蛋白在辅助性T细胞17(T helper cell 17,Th17细胞)的分化中起重要的作用。STAT3信号通路的异常也被证实与多种自身免疫相关性血液疾病的发生相关,如免疫性血小板减少症(immune thrombocytopenia,ITP)、再生障碍性贫血(aplastic anemia,AA)、自身免疫性溶血性贫血(autoimmune hemolytic anemia,AIHA)等。本文就STAT3蛋白与Th17细胞的分化及其与自身免疫相关性血液疾病的关系作一综述。 展开更多
关键词 STAT3 TH17细胞 自身免疫相关性血液疾病
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Characteristics of Thyroid Hormones in Hypertensive Hispanic Population
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作者 Rodrigo Verdugo Graciela Wendel +2 位作者 Liliana Trujillo Guillermo Orellano Lucia Fuentes 《Journal of Life Sciences》 2012年第2期155-163,共9页
The aim was to characterize thyroid function in Hispanic hypertensive population. Retrospective study of 1,023 individuals was performed, in which 68.23% had hypertension (74.21% women) and 37.25% had thyroid pathol... The aim was to characterize thyroid function in Hispanic hypertensive population. Retrospective study of 1,023 individuals was performed, in which 68.23% had hypertension (74.21% women) and 37.25% had thyroid pathology. Age, weight, blood pressure, biochemical measurements were recorded, mean age: 53.02 ± 14.80 yr, mean weight: 83.05 ±16.95 kg, thyrotropin-stimulating hormone (TSH) hypertensive patients: 5.55±1.63 μUI/mL and without hypertension: 3,72 ± 1.60 μUI/mL. TSH range concentration distributed by sex indicates: 1.50-2.49 μUI/mL men, 2.50-5.01 μUI/mL women. TSH categories vs. age were positively associated (r = + 0.114, P = 0.044) and hypertension by age was also correlated (r = + 0.178, P = 0.0001). Significant positive association we found between TSH and diastolic blood pressure (r = + 0.197, P = 0.008). Systolic and diastolic blood pressure vs. age were positively increasing (r = + 0.410,p = 0.0001; r = +0.285, P = 0.0001, respectively). Prevalence of thyroid pathology in hypertensive subjects are hyperthyroidism 5.87%; hypothyroidism 20.34% (5.73% subclinic) and autoimmune disease 6.25%. High percentage of hypertensive population has concomitant thyroid diseases, more common in women (50-70 years). Systematic surveillance for occult thyroid dysfunction in patients with hypertension could prevent future cardiovascular disease. 展开更多
关键词 Thyroid hormones blood pressure thyroid pathologies PATIENTS Hispanic.
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