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肿瘤坏死因子α基因多态性与中国人自身免疫肝病相关性研究 被引量:15
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作者 范列英 仲人前 +3 位作者 屠小卿 Thomas Pfeiffer Ralph Feltens 朱烨 周琳 《中华肝脏病杂志》 CAS CSCD 2004年第3期160-162,共3页
目的 探讨肿瘤坏死因子α(TNFα)启动子基因多念性与中国人自身免疫性肝炎(AIH)、原发性胆汁性肝硬化(PBC)发病的相关性。 方法 采用序列特异性聚合酶链式反应方法分析49例AIH、58例PBC患者外周血单核细胞基因组DNA TNFα启动子-308、23... 目的 探讨肿瘤坏死因子α(TNFα)启动子基因多念性与中国人自身免疫性肝炎(AIH)、原发性胆汁性肝硬化(PBC)发病的相关性。 方法 采用序列特异性聚合酶链式反应方法分析49例AIH、58例PBC患者外周血单核细胞基因组DNA TNFα启动子-308、238 G/A基因多态性,并与160例正常对照组比较。 结果 正常对照组中国人与白种人TNFα*2携带率差异较大。虽然从百分率上可以看出中国人PBC患者TNF α*2携带率低于正常对照组(10.34%与16.88%),但统计学上两者差异无显著性,TNFα-238位基因多态性分布也与正常对照组差异无显著性;AIH患者TNF α自动子-308、-238 G/A基因多态性均与正常人差异无显著性。 结论 不同人种自身免疫肝病的免疫相关基因不同,中国人AIH、PBC与TNFα启动子基因的多态性间不存在基因连锁关系。 展开更多
关键词 肿瘤坏死因子Α 基因多态性 中国人 自身免疫肝病 原发性胆汁性肝硬化
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维生素D受体基因多态性与中国人自身免疫肝病相关性研究 被引量:8
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作者 范列英 仲人前 +6 位作者 屠小卿 朱烨 弓长丽 周琳 赵智贤 Ralph Feltens Thomas Pfeiffer 《中华医学杂志》 CAS CSCD 北大核心 2003年第21期1852-1855,共4页
目的 探讨维生素D受体 (VDR)基因多态性与中国人自身免疫性肝炎 (AIH)和原发性胆汁性肝硬化 (PBC)发病的相关性。方法 采用限制性长度多态性分析 (restrictionfragmentlengthpolymorphismanalysis ,RFLP)法分析 4 9例AIH、5 8例PBC患... 目的 探讨维生素D受体 (VDR)基因多态性与中国人自身免疫性肝炎 (AIH)和原发性胆汁性肝硬化 (PBC)发病的相关性。方法 采用限制性长度多态性分析 (restrictionfragmentlengthpolymorphismanalysis ,RFLP)法分析 4 9例AIH、5 8例PBC患者外周血单核细胞基因组DNAVDR外显子2和外显子 7~外显子 9处限制性内切酶FokI、BsmI、ApaI和TaqI基因多态性 ,并与 16 0例正常对照组比较。结果 FokI基因多态性与AIH相关 ,AIH患者ff表型携带者明显高于正常对照组 (34 7%vs18 8% ,P =0 0 19) ;BsmI基因多态性与PBC相关 ,PBC患者携带Bb表型者较正常人明显降低(5 2 %vs 17 5 % ,P =0 0 2 1) ,而bb表型者明显升高 (94 8%vs 80 6 % ,P =0 0 1)。结论 研究结果表明VDR基因多态性与中国人AIH、PBC发病间存在基因连锁。虽然VDR基因表型分布不同 ,但不同人种 ,包括高加索人均存在相似的基因连锁。 展开更多
关键词 维生素D受体基因多态性 中国人 自身免疫肝病 相关性研究 原发性胆汁性肝硬化
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自身免疫性肝病及其重叠综合征的诊断及治疗 被引量:5
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作者 王一飞 陆伦根 《临床肝胆病杂志》 CAS 2012年第5期323-325,共3页
自身免疫性肝病主要包括自身免疫性肝炎(autoimmunehepatitis,AIH)、原发性胆汁性肝硬化(primary biliary cirrhosis,PBC)、原发性硬化性胆管炎(primary sclerosing cholangitis,PSC)及其相互重叠的综合征,但就相互重叠关联而言... 自身免疫性肝病主要包括自身免疫性肝炎(autoimmunehepatitis,AIH)、原发性胆汁性肝硬化(primary biliary cirrhosis,PBC)、原发性硬化性胆管炎(primary sclerosing cholangitis,PSC)及其相互重叠的综合征,但就相互重叠关联而言尚没有明确的定义。 展开更多
关键词 肝疾病 自身免疫肝病 重叠综合征
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暗示性心理护理干预在自身免疫学肝病患者中的应用效果 被引量:3
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作者 王婷婷 王晓辉 《中国医药指南》 2021年第4期206-207,共2页
目的探讨暗示性心理护理干预在自身免疫学肝病患者中的应用效果。方法本次研究对在我院接受治疗的自身免疫学肝病患者的临床资料进行回顾性分析,于2017年2月至2018年2月选取98例作为研究对象,所有患者信息均输入Excel表格进行编号,按照... 目的探讨暗示性心理护理干预在自身免疫学肝病患者中的应用效果。方法本次研究对在我院接受治疗的自身免疫学肝病患者的临床资料进行回顾性分析,于2017年2月至2018年2月选取98例作为研究对象,所有患者信息均输入Excel表格进行编号,按照编号的单双数分为两组(各49例),其中49例单数者实施常规护理,作为对照组,49例双数者实施暗示性心理护理,作为观察组。比较两组患者护理效果。结果干预后,观察组不良情绪改善情况、依从性、护理满意度均显著优于对照组(P<0.05)。结论在自身免疫学肝病患者中实施暗示性心理护理干预,可明显缓解患者不良情绪,提高患者依从性与护理满意度。 展开更多
关键词 自身免疫肝病 暗示性心理护理 焦虑 抑郁 依从性 满意度
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不同临床类型肝病患者血清中自身抗体的检测及临床应用 被引量:10
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作者 周晓冬 钱宏波 +3 位作者 刘会利 白妙 赵汉东 刘红莉 《海南医学》 CAS 2016年第10期1602-1605,共4页
目的分析不同临床类型肝病患者血清中各种自身抗体的存在状况,探讨其临床应用价值。方法采用间接免疫荧光法和免疫印迹法,对我院2010年6月至2014年2月3 124例不同类型肝病患者和200例正常健康体检者血清中的抗核抗体(ANA)、抗线粒体抗体... 目的分析不同临床类型肝病患者血清中各种自身抗体的存在状况,探讨其临床应用价值。方法采用间接免疫荧光法和免疫印迹法,对我院2010年6月至2014年2月3 124例不同类型肝病患者和200例正常健康体检者血清中的抗核抗体(ANA)、抗线粒体抗体(AMA)、抗平滑肌抗体(ASMA)、抗肝肾微粒体抗体(LKM)和自身免疫肝病谱等9项指标进行检测。结果病毒性肝炎ANA、AMA阳性率分别为11.11%、0.39%,抗肝抗原自身抗体检测阳性率分别为AMA M22.22%,M2-3E 1.86%、Sp100 0.59%、PML 0.42%、gp210 3.81%、LKM-1 0.62%、LC-1 2.28%、SLA-LP 0.26%、Ro52 10.6%。自身免疫性肝病ANA、AMA阳性率分别为90.63%、78.13%,抗肝抗原自身抗体检测阳性率分别依次为71.87%,71.87%、6.25%、6.25%、65.63%、3.13%、0、21.88%、93.75%。与病毒性肝炎比较,自身免疫肝病的9项指标以及ANA、AMA的差异有统计学意义(P<0.01)。与正常对照组比较,丙肝、自身免疫肝病、药物性肝炎的ANA阳性率的差异有显著统计学意义(P<0.01)。甲肝、戊肝、脂肪肝血清中未检测出自身抗体。与病毒性肝炎比较,药物性肝炎的ANA检出率差异有显著统计学意义(P<0.01)。各型肝炎患者ANA的荧光模型存在差异。结论检测自身抗体的类型、滴度以及荧光模型对于不同类型肝病的诊断和治疗具有临床参考价值。 展开更多
关键词 病毒性肝炎 抗核抗体 自身免疫肝病 自身抗体 临床应用
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安徽地区胆汁淤积性肝病病理学病因分析
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作者 宁玲 刘贞君 +7 位作者 李伟 刘雯 李卫 张振华 方卫东 高有方 郑晓玮 李磊 《内科理论与实践》 2022年第1期53-57,共5页
目的:探讨不明原因胆汁淤积性肝病患者的病理学病因分布情况。方法:收集2017年12月至2021年11月安徽地区7所医院收治的139例胆汁淤积起病的不明原因肝功能异常患者的个人信息、临床资料、实验室检查及肝穿刺病理结果,对观察指标进行统... 目的:探讨不明原因胆汁淤积性肝病患者的病理学病因分布情况。方法:收集2017年12月至2021年11月安徽地区7所医院收治的139例胆汁淤积起病的不明原因肝功能异常患者的个人信息、临床资料、实验室检查及肝穿刺病理结果,对观察指标进行统计学分析,探明胆汁淤积性肝病患者病理析因的主要分布情况及肝脏穿刺的诊断价值。结果:139例以胆汁淤积为主要表现的不明原因肝功能异常患者中女性105例,男性34例,平均年龄(50.2±11.5)岁。所有患者全部进行肝穿刺病理学检查,结合临床资料最后明确诊断121例(87.1%),其中自身免疫性肝病85例(61.2%),包括原发性胆汁性胆管炎56例(40.3%),自身免疫性肝炎15例(10.8%),自身免疫性肝炎合并原发性胆汁性胆管炎11例(7.9%);药物性肝损伤21例(15.1%);代谢性脂肪性肝病5例(3.6%);胆管消失综合征2例(1.4%),病因暂不明确18例(12.9%)。自身免疫性肝病组患者的碱性磷酸酶(alkaline phosphatase,ALP)水平明显偏高[291.0(225.0,387.0)U/mL比236.0(181.0,293.5)U/mL,P=0.002]。结论:胆汁淤积起病的不明原因肝损害以女性居多,疾病谱分布主要为自身免疫性肝病,尤其是原发性胆汁性胆管炎,其次为药物性肝损伤。ALP水平可能可以帮助鉴别患者是否存在自身免疫性肝病。 展开更多
关键词 胆汁淤积性肝病 自身免疫肝病 不明原因肝功能异常 肝脏病理
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自身免疫性肝病的发病机制 被引量:7
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作者 李海 贾继东 《临床消化病杂志》 2008年第6期327-329,共3页
关键词 自身免疫肝病 发病机制
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自身免疫性肝病相关抗体(IgAGM)的联合检测(间接免疫荧光法)及其临床应用 被引量:1
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作者 任忠萍 《科学中国人》 2017年第8X期78-78,共1页
目的:探讨自身免疫肝病相关抗体的联合检测及临床应用。方法:选取2016年7月至2017年6月来我院治疗的肝功异常原因待查的419例患者(男性158例,女性261例)为研究对象,采用间接免疫荧光方法学,多项基质联合检测人血清内的自身免疫性肝病相... 目的:探讨自身免疫肝病相关抗体的联合检测及临床应用。方法:选取2016年7月至2017年6月来我院治疗的肝功异常原因待查的419例患者(男性158例,女性261例)为研究对象,采用间接免疫荧光方法学,多项基质联合检测人血清内的自身免疫性肝病相关抗体.结果:抗体阳性检出率分别为44%、11%、5%、0.2%、5.7%、0、0、0.5%、4%、1.2%、1.7%。结论:多项基质联合检测,可极大地提高自身免疫性肝病的诊断率. 展开更多
关键词 间接免疫荧光法 自身免疫肝病相关抗体 联合检测 临床应用
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抗核抗体检测对自身免疫性肝病诊断的临床意义 被引量:3
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作者 杨结 《中国医疗器械信息》 2018年第24期80-81,共2页
目的:探讨分析抗核抗体(ANA)检测对自身免疫性肝病诊断的临床价值。方法:选取本院2016年1月~2017年12月期间收治的90例自身免疫性肝病患者,包括34例原发性胆汁性肝硬化(PBC)患者、29例自身免疫性肝炎(AIH)患者和27例原发性硬化胆管炎(P... 目的:探讨分析抗核抗体(ANA)检测对自身免疫性肝病诊断的临床价值。方法:选取本院2016年1月~2017年12月期间收治的90例自身免疫性肝病患者,包括34例原发性胆汁性肝硬化(PBC)患者、29例自身免疫性肝炎(AIH)患者和27例原发性硬化胆管炎(PSC)患者,34例慢性乙型肝炎(HBV)患者以及40例体检健康患者作为研究对象。对所有研究对象分别采用间接免疫荧光法和免疫印迹法进行抗核抗体检测,检测结果分别记为PBC组、AIH组、PSC组、HBV组和对照组,观察每组患者的抗核抗体(ANA)检出率。结果:PBC组的ANA检出率为85.3%, AIH组的ANA检出率为72.4%, PSC组的ANA检出率为40.7%, HBV组的ANA检出率为11.8%,对照组的ANA检出率为2.5%,各组与对照组的ANA阳性检出率差异均具有统计学意义(P<0.05)。结论:对于自身免疫性肝病患者临床采用抗核抗体检测可以有效帮助疾病的诊断,提高诊断准确率,对于后续疾病的治疗具有积极的意义。 展开更多
关键词 抗核抗体 自身免疫肝病 诊断
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IgG4-related sclerosing disease 被引量:51
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作者 Terumi Kamisawa Atsutake Okamoto 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第25期3948-3955,共8页
Based on histological and immunohistochemical exami- nation of various organs of patients with autoimmune pancreatitis (AIP), a novel clinicopathological entity of IgG4-related sclerosing disease has been proposed. ... Based on histological and immunohistochemical exami- nation of various organs of patients with autoimmune pancreatitis (AIP), a novel clinicopathological entity of IgG4-related sclerosing disease has been proposed. This is a systemic disease that is characterized by extensive IgG4-positive plasma cells and T-lymphocyte infiltration of various organs. Clinical manifestations are apparent in the pancreas, bile duct, gallbladder, salivary gland, retroperitoneum, kidney, lung, and prosrate, in which tissue fibrosis with obliterative phlebitis is pathologically induced. AlP is not simply pancreatitis but, in fact, is a pancreatic disease indicative of IgG4- related sclerosing diseases. This disease includes AlP, sclerosing cholangitis, cholecystitis, sialadenitis, retro-peritoneal fibrosis, tubulointerstitial nephritis, interstitial pneumonia, prostatitis, inflammatory pseudotumor and lymphadenopathy, all IgG4-related. Most IgG4-related sclerosing diseases have been found to be associated with AlP, but also those without pancreatic involvement have been reported. In some cases, only one or two organs are clinically involved, while in others, three or four organs are affected. The disease occurs predominantly in older men and responds well to steroid therapy. Serum IgG4 levels and immunos-taining with anti-IgG4 antibody are useful in making the diagnosis. Since malignant tumors are frequently suspected on initial presentation, IgG4-related sclerosing disease should be considered in the differential diagnosis to avoid unnecessary surgery. 展开更多
关键词 Autoimmune pancreatitis IGG4 IgG4-related sclerosing disease Retroperitoneal fibrosis Sclerosing cholangitis
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Budesonide induces complete remission in autoimmune hepatitis 被引量:14
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作者 Antal Csepregi Christoph R(o|¨)cken +1 位作者 Gerhard Treiber Peter Malfertheiner 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第9期1362-1366,共5页
AIM: Prednisone and azathioprine represent the standard treatment for autoimmune hepatitis (AIH). However, only 65% of the patients enter complete histological remission. Recently, budesonide (BUD) was reported t... AIM: Prednisone and azathioprine represent the standard treatment for autoimmune hepatitis (AIH). However, only 65% of the patients enter complete histological remission. Recently, budesonide (BUD) was reported to be a promising alternative. In this study we assessed the efficacy and safety of BUD in AIH. METHODS: Eighteen patients (12 women, 6 men; mean age 45.4±21 years) with AIH were treated with BUD (Budenofalk) 3 mg thrice daily and followed up for at least 24 wk. Seven patients also had features of primary biliary cirrhosis (n = 5) or primary sclerosing cholangitis (n = 2). Advanced liver fibrosis or cirrhosis was present in RESULTS: Fifteen (83%) patients had a complete clinical and biochemical remission. Ten patients, including five with acute hepatitis, were given BUD as first-line therapy, of which seven enter remission. Three patients, two with liver cirrhosis, did not improve. All patients with second-line therapy experienced long-term remission. A histological remission was also seen in three patients. Clinically relevant BUD-induced side effects were recorded only in patients with liver cirrhosis (n = 4). CONCLUSION: BUD is effective in remission induction in the majority of our patients with AIH. Side effects and treatment failure was mainly observed in patients with liver cirrhosis. 展开更多
关键词 BUDESONIDE Autoimmune hepatitis Complete remission Adverse events
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Liver disease in pregnancy 被引量:15
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作者 Noel M Lee Carla W Brady 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第8期897-906,共10页
Liver diseases in pregnancy may be categorized into liver disorders that occur only in the setting of pregnancy and liver diseases that occur coincidentally with pregnancy. Hyperemesis gravidarum, preeclampsia/eclamps... Liver diseases in pregnancy may be categorized into liver disorders that occur only in the setting of pregnancy and liver diseases that occur coincidentally with pregnancy. Hyperemesis gravidarum, preeclampsia/eclampsia, syndrome of hemolysis, elevated liver tests and low platelets (HELLP), acute fatty liver of pregnancy, and intrahepatic cholestasis of pregnancy are pregnancy-specific disorders that may cause elevations in liver tests and hepatic dysfunction. Chronic liver diseases, including cholestatic liver disease, autoimmune hepatitis, Wilson disease, and viral hepatitis may also be seen in pregnancy. Management of liver disease in pregnancy requires collaboration between obstetricians and gastroenterologists/hepatologists. Treatment of pregnancy-specific liver disorders usually involves delivery of the fetus and supportive care, whereas management of chronic liver disease in pregnancy is directed toward optimizing control of the liver disorder. Cirrhosis in the setting of pregnancy is less commonly observed but offers unique challenges for patients and practitioners. This article reviews the epidemiology, pathophysiology, diagnosis, and management of liver diseases seen in pregnancy. 展开更多
关键词 Liver disease PREGNANCY Maternal outcome Fetal outcome Cesarean section CHOLESTASIS Viral hepatitis.
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Role of autoimmunity in primary biliary cirrhosis 被引量:8
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作者 Tian-Yan Shi Feng-Chun Zhang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第48期7141-7148,共8页
Primary biliary cirrhosis(PBC) is an autoimmune liver disease characterized by the presence of serum autoantibodies and chronic nonsuppurative destructive cholangitis.The pathogenesis of PBC involves environmental fac... Primary biliary cirrhosis(PBC) is an autoimmune liver disease characterized by the presence of serum autoantibodies and chronic nonsuppurative destructive cholangitis.The pathogenesis of PBC involves environmental factors,genetic predisposition and loss of immune tolerance.In recent years,it has become univocally accepted that an inappropriately activated immune response is one of the most important factors in PBC.In this study,the role of autoimmunity in PBC is summarized and a feasible research orientation is recommended. 展开更多
关键词 Primary biliary cirrhosis Autoimmunity Humoral immunity Cellular immunity Nonspecific immunity
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Etiological role of brucellosis in autoimmune hepatitis 被引量:3
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作者 Colakoglu Onder Taskiran Bengur +5 位作者 Adnan Kirci Tunakan Mine Buyrac Zafer Unsal Belkis Aksoz Kadir Yorukoglu Gazi 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第14期2200-2202,共3页
To show that brucellosis may trigger autoimmune hepatitis(AIH), in addition to nonspecific liver involvement and toxic hepatitis, due to a class effect of tetracycline family used for treatment. We present a female pa... To show that brucellosis may trigger autoimmune hepatitis(AIH), in addition to nonspecific liver involvement and toxic hepatitis, due to a class effect of tetracycline family used for treatment. We present a female patient admitted to our hospital due to partially improved fatigue and elevated liver enzymes following doxycycline and streptomycin usage for brucellosis. Brucellosis is endemic in our country, Turkey. It may involve any organ in the body. Liver is frequently involved. Doxycycline used for treatment occasionally may lead to hepatotoxicity. AIH is a necroinflammatory disease of the liver. Certain drugs (e.g. Minocycline), toxins, and viruses (hepatitis B, hepatitis C, EBV, etc.) can trigger AIH. Only one case of AIH probably caused by doxycycline and brucellosis was reported. We discuss the relationship between brucellosis, AIH, and hepatotoxicity of doxycycline. Brucellosis may trigger AIH. 展开更多
关键词 BRUCELLOSIS Autoimmune hepatitis DOXYCYCLINE
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Genetic association of cytokines polymorphisms with autoimmune hepatitis and primary biliary cirrhosis in the Chinese 被引量:9
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作者 Lie-YingFan xiao-QingTu +4 位作者 TU,YeZhu ThomasPfeiffer RalphFeltens WinfriedStoecker Ren-QianZhong 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第18期2768-2772,共5页
AIM: To characterize gene polymorphism of several cytokine gene in-patients with AIH and PBC and to analyze the difference of the polymorphism distribution between Chinese patients and healthy controls.METHODS: The st... AIM: To characterize gene polymorphism of several cytokine gene in-patients with AIH and PBC and to analyze the difference of the polymorphism distribution between Chinese patients and healthy controls.METHODS: The study population consisted of 62 patients with AIH, and 77 patients with PBC. The genetic profile of four cytokines was analyzed by restriction fragmentlength polymorphism after specific PCR amplification (PCR-RFLP) or sequence-specific primers PCR (SSP-PCR). The analyzed gene polymorphism included interleukin-1 (IL-1) (at position +3 953 and IL-1RN intron 2), IL-6 (atposition -174), IL-10 promoter (at position -1 082, -819, and -592). The control group consisted of 160 healthyblood donors.RESULTS: The majority of Chinese people including patients and healthy controls exhibited IL-1B 1,1genotype, and there was no significant difference in AIH, PBC patients and controls. There were highly statistically significant differences in the distribution of the IL-1RN gene polymorphism between the patients with PBCcompared with controls. The frequency of IL-1RN 1,1was significantly higher (90.9% vs 79.4%, P = 0.03)and the frequency of IL-1RN 1,2 was significantly lower in PBC patients (6.5% vs 17.5%, P = 0.01). No statistical difference was observed between AIH patients and controls. All of the 160 healthy controls and 62 cases of AIH patients exhibited IL-6-174GG genotype, and there were four cases, which expressed IL-6-174GC genotype in 77 cases of PBC patients. The frequency of IL-6-174GC was markedly significantly higher in PBC patients compared with controls (5.2% vs 0%, P = 0.004). No statistically significant difference was found in the distribution of IL-10 promoter genotype in AIH and PBC patients compared with controls. CONCLUSION: The polymorphisms of IL-1RN and IL-6 -174G/C appear to be associated with PBC in Chinese patients. 展开更多
关键词 Autoimmune hepatitis Primary biliary cirrhosis CYTOKINE POLYMORPHISMS Gene susceptibility
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Prevalence of autoantibodies and the risk of autoimmune thyroid disease in children with chronic hepatitis C virus infection treated with interferon-α 被引量:2
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作者 Stephan Gehring Ulrike Kullmer +3 位作者 Sabine Koeppelmann Patrick Gerner Philip Wintermeyer Stefan Wirth 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第36期5787-5792,共6页
AIM: To evaluate the prevalence of autoantibodies in chronic hepatitis C virus (HCV)-infected children focusing on thyroid autoimmunity.METHODS: We investigated the prevalence of autoantibodies in 123 chronic HCV-... AIM: To evaluate the prevalence of autoantibodies in chronic hepatitis C virus (HCV)-infected children focusing on thyroid autoimmunity.METHODS: We investigated the prevalence of autoantibodies in 123 chronic HCV-infected children before, during and after monotherapy with interferon-alpha (IFN-α) or combined treatment with interferon-α or peginterferon-α and ribavirin. Besides antibodies against smooth muscle (SMA), nuclei (ANA), and liver/kidney microsomes (1KM), the incidence of antithyroid peroxidase antibodies as well as thyroid function parameters (TSH, FT3 and FT4) were determined.RESULTS: We found that 8% of children had autoantibodies before treatment. During treatment, 18% of children were found positive for at least one autoantibody; 15.5% of children developed pathologic thyroid values during IFN-α treatment compared to only one child before therapy. Six children had to be substituted while developing laboratory signs of hypothyroidism.CONCLUSION: Our data indicate a strong correlation between interferon-α treatment and autoimmune phenomena, notably the emergence of thyroid antibodies. The fact that some children required hormone replacement underlines the need of close monitoring in particularly those who respond to therapy and have to be treated for more than 6 mo. 展开更多
关键词 Hepatitis C treatment CHILDREN Thyroiddysfunction AUTOANTIBODIES
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Diagnostic criteria for autoimmune hepatitis in children: A challenge for pediatric hepatologists 被引量:4
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作者 Priscila Menezes Ferri Alexandre Rodrigues Ferreira +1 位作者 Débora Marques Miranda Ana Cristina Sim■es e Silva 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第33期4470-4473,共4页
Autoimmune hepatitis (AIH) is a progressive inflammatory liver disorder that is rare in children and adolescents. AIH has a broad clinical spectrum and a quick response to treatment with corticosteroids and immunosupp... Autoimmune hepatitis (AIH) is a progressive inflammatory liver disorder that is rare in children and adolescents. AIH has a broad clinical spectrum and a quick response to treatment with corticosteroids and immunosuppressive medication. The available diagnosis criteria have limitations and should be evaluated in pediatric populations. Recently, some studies reported that the 2008 simplified diagnostic criteria for AIH could be used in children with high sensibility and specificity. In addition, the authors reported that globulin and immunoglobulin G levels can be used interchangeably for diagnostic purposes. They also demonstrated that the 2008 simplified criteria fail in identifying patients with fulminant hepatic failure. Here, we discuss the limitations of the use of these criteria in pediatric patients and the requirement of more studies to improve the diagnosis of AIH in children. 展开更多
关键词 Child Autoimmune hepatitis Liver diseases Diagnosis Autoimmunity
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多能干细胞向肝细胞分化的微环境
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作者 周文丽 朱樑 《中华细胞与干细胞杂志(电子版)》 2012年第2期48-52,共5页
一、背景 终末期肝病(end stage liver disease,ESLD)指各种原因如肝炎、肝硬化、肝癌、药物性肝损伤和自身免疫肝病等导致肝功能极度减退甚至衰竭的一种病理状态。它是很多肝脏疾病的终末状态,预后较差,在发展中国家的发病率逐年上... 一、背景 终末期肝病(end stage liver disease,ESLD)指各种原因如肝炎、肝硬化、肝癌、药物性肝损伤和自身免疫肝病等导致肝功能极度减退甚至衰竭的一种病理状态。它是很多肝脏疾病的终末状态,预后较差,在发展中国家的发病率逐年上升[1]。目前治疗肝癌或终末期肝病的理想方案是肝移植[2],但是供肝不足和免疫排斥是目前移植的两大难题[3], 展开更多
关键词 肝细胞分化 多能干细胞 微环境 终末期肝病 自身免疫肝病 药物性肝损伤 病理状态 liver
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