目的:探讨结肠途径经内镜肠道植管(transendoscopic enteral tubing, TET)行洗涤菌群移植(Washed Microbiota Transplantation, WMT)治疗自闭症谱系障碍(Autism Spectrum Disorders, ASD)患儿的护理要点。方法:以本院微生态医学科收治的...目的:探讨结肠途径经内镜肠道植管(transendoscopic enteral tubing, TET)行洗涤菌群移植(Washed Microbiota Transplantation, WMT)治疗自闭症谱系障碍(Autism Spectrum Disorders, ASD)患儿的护理要点。方法:以本院微生态医学科收治的ASD患儿为对象,总结提炼结肠TET行WMT治疗ASD患儿的护理要点。结果:对结肠TET行WMT治疗的ASD患儿实施有效的护理,不仅能提高患儿监护人配合度、照护能力,还能在确保医疗安全的情况下减少病患的其它各种负担及相关并发症,提高整体疗效和病患满意度。结论:对结肠TET行WMT治疗的ASD患儿提供有效的护理能够提升菌群移植的治疗效果,有助于患儿心理和行为的康复,有推广应用价值。Objective: To explore the nursing points of treatment of children with autism spectrum who underwent colonic transendoscopic enteral tubing (TET) for washed microbiota transplantation (WMT). Method: Taking children with ASD admitted to the Microecology Medicine Department of our hospital as the subjects, we summarized and refined the nursing points for the treatment of children with ASD who underwent colonic TET for WMT. Results: Effective nursing care for children with ASD who underwent colonic TET for WMT not only improves the cooperation and care ability of their guardians, but also reduces other burdens and related complications of patients while ensuring medical safety, improving overall efficacy and patient satisfaction. Conclusion: Effective nursing care for children with ASD who underwent colonic TET for WMT can enhance the therapeutic effect of microbial transplantation, help children’s psychological and behavioral rehabilitation, and have value for promotion and application.展开更多
目的使用孟德尔随机化(MR)研究方法验证肠道微生物群(GM)与自闭症谱系障碍(ASD)的因果关系。方法GM数据来源于MiBioGen联盟进行的全基因组关联研究荟萃分析,包括18340例受试者;ASD汇总统计数据来自爱丁堡大学开放型全基因组关联研究项目...目的使用孟德尔随机化(MR)研究方法验证肠道微生物群(GM)与自闭症谱系障碍(ASD)的因果关系。方法GM数据来源于MiBioGen联盟进行的全基因组关联研究荟萃分析,包括18340例受试者;ASD汇总统计数据来自爱丁堡大学开放型全基因组关联研究项目(IEU Open GWAS)发布数据。采用逆方差加权法(IVW)、加权众数和加权中位数估计(WME)进行两样本孟德尔随机化研究;采用Cochran’s Q检验、MR-PRESSO和MR Egger截距检验进行敏感性分析,以评估结果的稳定性。结果Dorea(OR=0.783,95%CI:0.676~0.908)、瘤胃球菌(RuminococcaceaeUCG005)(OR=0.781,95%CI:0.693~0.880)、瘤胃球菌(RuminococcaceaeUCG014)(OR=0.863,95%CI:0.761~0.980)和Victivallis菌属(OR=0.917,95%CI:0.857~0.981)可能对ASD有保护作用,而巴恩斯氏菌(Barnesiella)(OR=1.182,95%CI:1.047~1.334)、副拟杆菌(Parabacteroides)(OR=1.213,95%CI:1.017~1.447)和苏黎世杆菌(Turicibacter)菌属(OR=1.129,95%CI:1.007~1.267)可能增加ASD的风险(P均<0.05)。结论GM和ASD之间具有因果关系,改善GM可能对预防和治疗ASD有一定的临床意义。展开更多
文摘目的:探讨结肠途径经内镜肠道植管(transendoscopic enteral tubing, TET)行洗涤菌群移植(Washed Microbiota Transplantation, WMT)治疗自闭症谱系障碍(Autism Spectrum Disorders, ASD)患儿的护理要点。方法:以本院微生态医学科收治的ASD患儿为对象,总结提炼结肠TET行WMT治疗ASD患儿的护理要点。结果:对结肠TET行WMT治疗的ASD患儿实施有效的护理,不仅能提高患儿监护人配合度、照护能力,还能在确保医疗安全的情况下减少病患的其它各种负担及相关并发症,提高整体疗效和病患满意度。结论:对结肠TET行WMT治疗的ASD患儿提供有效的护理能够提升菌群移植的治疗效果,有助于患儿心理和行为的康复,有推广应用价值。Objective: To explore the nursing points of treatment of children with autism spectrum who underwent colonic transendoscopic enteral tubing (TET) for washed microbiota transplantation (WMT). Method: Taking children with ASD admitted to the Microecology Medicine Department of our hospital as the subjects, we summarized and refined the nursing points for the treatment of children with ASD who underwent colonic TET for WMT. Results: Effective nursing care for children with ASD who underwent colonic TET for WMT not only improves the cooperation and care ability of their guardians, but also reduces other burdens and related complications of patients while ensuring medical safety, improving overall efficacy and patient satisfaction. Conclusion: Effective nursing care for children with ASD who underwent colonic TET for WMT can enhance the therapeutic effect of microbial transplantation, help children’s psychological and behavioral rehabilitation, and have value for promotion and application.
文摘目的使用孟德尔随机化(MR)研究方法验证肠道微生物群(GM)与自闭症谱系障碍(ASD)的因果关系。方法GM数据来源于MiBioGen联盟进行的全基因组关联研究荟萃分析,包括18340例受试者;ASD汇总统计数据来自爱丁堡大学开放型全基因组关联研究项目(IEU Open GWAS)发布数据。采用逆方差加权法(IVW)、加权众数和加权中位数估计(WME)进行两样本孟德尔随机化研究;采用Cochran’s Q检验、MR-PRESSO和MR Egger截距检验进行敏感性分析,以评估结果的稳定性。结果Dorea(OR=0.783,95%CI:0.676~0.908)、瘤胃球菌(RuminococcaceaeUCG005)(OR=0.781,95%CI:0.693~0.880)、瘤胃球菌(RuminococcaceaeUCG014)(OR=0.863,95%CI:0.761~0.980)和Victivallis菌属(OR=0.917,95%CI:0.857~0.981)可能对ASD有保护作用,而巴恩斯氏菌(Barnesiella)(OR=1.182,95%CI:1.047~1.334)、副拟杆菌(Parabacteroides)(OR=1.213,95%CI:1.017~1.447)和苏黎世杆菌(Turicibacter)菌属(OR=1.129,95%CI:1.007~1.267)可能增加ASD的风险(P均<0.05)。结论GM和ASD之间具有因果关系,改善GM可能对预防和治疗ASD有一定的临床意义。
