戊型肝炎是由戊型肝炎病毒（hepatitis E virus,HEV）引起的常见传染病,目前呈世界范围分布,在亚洲、中东、非洲等多个卫生条件较差的国家和地区,HEV是引起急性肝炎的首要因素[1,2]。免疫功能正常的人群感染HEV后,大部分为亚临床感染,...戊型肝炎是由戊型肝炎病毒（hepatitis E virus,HEV）引起的常见传染病,目前呈世界范围分布,在亚洲、中东、非洲等多个卫生条件较差的国家和地区,HEV是引起急性肝炎的首要因素[1,2]。免疫功能正常的人群感染HEV后,大部分为亚临床感染,少部分表现为急性自限性肝炎,病死率为0.5%~4.0%,孕妇感染后病死率高达25%[3]。展开更多
Objective. Fulminant hepatic failure (FHF) is a clinical syndrome of sudden and severe liver dysfunction accompanied by encephalopathy in a previously healthy person. In FHF, hepatocytes are severely damaged and ordin...Objective. Fulminant hepatic failure (FHF) is a clinical syndrome of sudden and severe liver dysfunction accompanied by encephalopathy in a previously healthy person. In FHF, hepatocytes are severely damaged and ordinary liver regeneration is impaired. We demonstrated that the expression of osteopontin (OPN), a multifunctional cytokine, was up-regulated in mouse oval cell (a stem-cell progenitor) induction models. Material and methods. Based on this finding, serum OPN levels were examined in 43 patients with FHF and in 45 patients with acute self-limited hepatitis (AH). To determine the cellular source of OPN, the expression of OPN was studied in a liver specimen derived from an FHF patient. Results. The mean OPN level of patients with FHF was 2.80±0.48 ng/ml (log10,±SD), which was significantly higher than that of the patientswith AH (2.42±0.39 ng/ml) (p = 0.003, unpaired t-test). Patients with elevated serum OPN levels had a significantly poorer prognosis than patients whose serum OPN levels were not elevated. In the FHF patient’s liver, OPN protein was expressed not only in inflammatory cells but also in regenerating hepatocytes and bile ductular structures. Conclusions. Our current study indicates that serum OPN levels increased in patients with FHF and that OPN might play an important role in liver regeneration due to activation of hepatic stem cells.展开更多
戊型肝炎（Hepatitis E，HE）是20世纪80年代初认识的一种病毒性肝炎。是由戊型肝炎病毒（Hepatitis E Virus，HEV）引起的急性自限性肝炎，又称为肠道传播型非甲非乙型肝炎病毒，归类于萼状病毒科。Meng等^[1]1997年首次从美国本地猪...戊型肝炎（Hepatitis E，HE）是20世纪80年代初认识的一种病毒性肝炎。是由戊型肝炎病毒（Hepatitis E Virus，HEV）引起的急性自限性肝炎，又称为肠道传播型非甲非乙型肝炎病毒，归类于萼状病毒科。Meng等^[1]1997年首次从美国本地猪中分离出野生株HE病毒，由此也揭示了动物作为戊型肝炎传染源的可能性。展开更多
文摘戊型肝炎是由戊型肝炎病毒（hepatitis E virus,HEV）引起的常见传染病,目前呈世界范围分布,在亚洲、中东、非洲等多个卫生条件较差的国家和地区,HEV是引起急性肝炎的首要因素[1,2]。免疫功能正常的人群感染HEV后,大部分为亚临床感染,少部分表现为急性自限性肝炎,病死率为0.5%~4.0%,孕妇感染后病死率高达25%[3]。
文摘Objective. Fulminant hepatic failure (FHF) is a clinical syndrome of sudden and severe liver dysfunction accompanied by encephalopathy in a previously healthy person. In FHF, hepatocytes are severely damaged and ordinary liver regeneration is impaired. We demonstrated that the expression of osteopontin (OPN), a multifunctional cytokine, was up-regulated in mouse oval cell (a stem-cell progenitor) induction models. Material and methods. Based on this finding, serum OPN levels were examined in 43 patients with FHF and in 45 patients with acute self-limited hepatitis (AH). To determine the cellular source of OPN, the expression of OPN was studied in a liver specimen derived from an FHF patient. Results. The mean OPN level of patients with FHF was 2.80±0.48 ng/ml (log10,±SD), which was significantly higher than that of the patientswith AH (2.42±0.39 ng/ml) (p = 0.003, unpaired t-test). Patients with elevated serum OPN levels had a significantly poorer prognosis than patients whose serum OPN levels were not elevated. In the FHF patient’s liver, OPN protein was expressed not only in inflammatory cells but also in regenerating hepatocytes and bile ductular structures. Conclusions. Our current study indicates that serum OPN levels increased in patients with FHF and that OPN might play an important role in liver regeneration due to activation of hepatic stem cells.
文摘戊型肝炎（Hepatitis E，HE）是20世纪80年代初认识的一种病毒性肝炎。是由戊型肝炎病毒（Hepatitis E Virus，HEV）引起的急性自限性肝炎，又称为肠道传播型非甲非乙型肝炎病毒，归类于萼状病毒科。Meng等^[1]1997年首次从美国本地猪中分离出野生株HE病毒，由此也揭示了动物作为戊型肝炎传染源的可能性。
