The Robin Problem for Singular Perturbed Integral Differential Equations of Volterra Type

In this paper,making use of upper and lower solutions,we first prove the existence of the solu tion for integral differential equation of Volterra type.Then applying the theory of differential in equalities obtained,under the appropriate assumptions,by constructing the special function of upper and lower solutions,we demonstrate the existence of the solution for singularly preturbed integral differential equation of Volterra type,and give the uniformly valid approximate estimation.

Potential role of chitinase 3-like-1 in inflammation-associated carcinogenic changes of epithelial cells

The family of mammalian chitinases includes members both with and without glycohydrolase enzymatic activity against chitin, a polymer of N-acetylglucosamine. Chitin is the structural component of fungi, crustaceans, insects and parasitic nematodes, but is completely absent in mammals. Exposure to antigens containing chitin- or chitin-like structures sometimes induces strong T helper type-I responses in mammals, which may be associated with the induction of mammalian chitinases. Chitinase 3-like-1 （CHI3L1）, a member of the mammalian chitinase family, is induced specifically during the course of inflammation in such disorders as inflammatory bowel disease, hepatitis and asthma. In addition, CHI3L1 is expressed and secreted by several types of solid tumors including glioblastoma, colon cancer, breast cancer and malignant melanoma. Although the exact function of CHI3L1 in inflammation and cancer is still largely unknown, CHI3L1 plays a pivotal role in exacerbating the inflammatory processes and in promoting angiogenesis and remodeling of the extracellular matrix. CHI3L1 may be highly involved in the chronic engagement of inflammation which potentiates development of epithelial tumorigenesis presumably by activating the mitogen-activated protein kinase and the protein kinase B signaling pathways. Anti-CHI3L1 antibodies or pan-chitinase inhibitors may have the potential to suppress CHI3Ll-mediated chronic inflammation and the subsequent carcinogenic change in epithelial cells.

Miniature Actuators and Scaling Effect

The paper deals with miniature actuators and scaling effect, which occurs in using of these actuators. Scaling effect describes how much decreased performance in miniaturized actuator is. Scaling effect law helps to make perfect decision for right type of actuator. This analysis should be as the first strategic step for actuator selection. Research in area of in-pipe machine shows that scaling effect in both used actuator types （electromagnetic and piezoelectric） is the same. Passive forces cannot be neglected, because of their values, which are comparable with active forces in system. There is a potential risk, that designed system will have bigger passive forces than active forces and system cannot fulfill requirements. Energy sources selection has also important role in system design with respecting the energy requirements of selected actuator. Consequently, energy balance is also important viewpoint for actuator selection.

A Longitudinal Study of Human Exposure to Potential Nuclear Power Plant Risk

This study constructs a potential risk index(PRI) for the 65 U.S.-based commercial nuclear power plant(NPP) sites in relation to their surrounding populations. Four risk levels are defined: low risk, moderate risk,high risk, and very high risk. Discrepancies that exist in the sociodemographic characteristics of the host communities’ populations are examined as sorted by risk-level category.It is found that a greater percentage of minority groups are exposed to the highest levels of risk. In addition, percent 'Hispanic' and percent 'Other,'a grouping that includes multiracial, mixed, interracial, as well as Hispanic and Latino groups(for example, Mexican, Puerto Rican,Cuban, or Spanish) are categories that show the greatest percent change in both the period 1990–2000 and2000–2010.