目的评估美国人群中日常摄入不同酒类与过敏症状和过敏原致敏之间的关系。方法选取美国国家健康与营养调查(national health and nutrition examination survey, NHANES)2005~2006年对过敏、饮酒和模型协变量有完整信息的1752例数据进...目的评估美国人群中日常摄入不同酒类与过敏症状和过敏原致敏之间的关系。方法选取美国国家健康与营养调查(national health and nutrition examination survey, NHANES)2005~2006年对过敏、饮酒和模型协变量有完整信息的1752例数据进行逻辑回归分析,以确定饮酒与过敏症状和过敏原致敏之间的关联。结果在NHANES受试者中,每周至少饮用5次啤酒者过敏症状的几率是每月饮用1~3次啤酒者的1.8倍(OR=1.752,95%CI:1.014~3.027)。控制了潜在的混杂因素后,每周至少饮用5次啤酒者出现致敏的几率是每月仅饮用1~3次啤酒者的2.4倍(OR=2.414,95%CI:1.223~4.766)。而饮用白酒和葡萄酒和过敏症状和过敏原致敏之间无明显关联。结论本研究表明饮酒与过敏反应的发生和过敏原致敏之间存在联系。过多摄入啤酒增加过敏风险,而葡萄酒和白酒的摄入与过敏反应和致敏之间未见明显关联。展开更多
Pen a 1 is a major shrimp allergen that induces an allergy. The aim of this study is to assess the effect of simulated gastrointestinal fluids on the allergenicity of Pen a 1. Purified Pen a 1 from shrimp （Penaeus va...Pen a 1 is a major shrimp allergen that induces an allergy. The aim of this study is to assess the effect of simulated gastrointestinal fluids on the allergenicity of Pen a 1. Purified Pen a 1 from shrimp （Penaeus vannamei） was subjected to digestion in SGF （simulated gastric fluid） and SIF （simulated intestinal fluid） for a set time. The allergenicity of digestive Pen a 1 was analyzed by immunoblotting and Ci-ELISA, using pool sera from patients with shrimp specific IgE. The results showed that Pen a 1 exhibited a decrease in allergenicity with increasing digestion time in the SGF and SIF. However, Pen a 1 exhibited strong resistance to digestive fluids, and all yielded fragments （33 kD, 23 kD, and 14 kD） showed allergic activity. Therefore, anti-digestion may be an important factor for Pen a 1 to induce an allergy.展开更多
文摘目的评估美国人群中日常摄入不同酒类与过敏症状和过敏原致敏之间的关系。方法选取美国国家健康与营养调查(national health and nutrition examination survey, NHANES)2005~2006年对过敏、饮酒和模型协变量有完整信息的1752例数据进行逻辑回归分析,以确定饮酒与过敏症状和过敏原致敏之间的关联。结果在NHANES受试者中,每周至少饮用5次啤酒者过敏症状的几率是每月饮用1~3次啤酒者的1.8倍(OR=1.752,95%CI:1.014~3.027)。控制了潜在的混杂因素后,每周至少饮用5次啤酒者出现致敏的几率是每月仅饮用1~3次啤酒者的2.4倍(OR=2.414,95%CI:1.223~4.766)。而饮用白酒和葡萄酒和过敏症状和过敏原致敏之间无明显关联。结论本研究表明饮酒与过敏反应的发生和过敏原致敏之间存在联系。过多摄入啤酒增加过敏风险,而葡萄酒和白酒的摄入与过敏反应和致敏之间未见明显关联。
基金Supported by the National High Technology Research and Development Program of China (863 Program) (NO.2006AA09Z427)the National Natural Science Foundation of China (Nos.30800859,30871948)
文摘Pen a 1 is a major shrimp allergen that induces an allergy. The aim of this study is to assess the effect of simulated gastrointestinal fluids on the allergenicity of Pen a 1. Purified Pen a 1 from shrimp （Penaeus vannamei） was subjected to digestion in SGF （simulated gastric fluid） and SIF （simulated intestinal fluid） for a set time. The allergenicity of digestive Pen a 1 was analyzed by immunoblotting and Ci-ELISA, using pool sera from patients with shrimp specific IgE. The results showed that Pen a 1 exhibited a decrease in allergenicity with increasing digestion time in the SGF and SIF. However, Pen a 1 exhibited strong resistance to digestive fluids, and all yielded fragments （33 kD, 23 kD, and 14 kD） showed allergic activity. Therefore, anti-digestion may be an important factor for Pen a 1 to induce an allergy.
