酒精依赖症患者的致癌率——与ALDH_2基因多型的关系

本世纪初（１９１０年）Ｌａｍｕ曾经提出过，经常饮用法国高浓度蒸馏酒（苦艾酒）者食管癌的发病率很高。其后，人们又从流行病学角度对饮酒与致癌的关系进行了广泛的研究，结果表明饮酒与口腔癌、咽喉癌和食管癌等有着密切的关系。近年来，由于分子流行病学的发展，又进...

“小三阳”比“大三阳”更易致癌

大部分肝癌由乙肝发展而来，但是很多患者误以为“大三阳”的致癌率高于“小三阳”。在广东省肝脏病学会3月6日举办的国内病毒性肝炎研究临床应用推介会上，专家表示，研究表明“小三阳”致癌人数多于“大三阳”。专家呼吁重视肝功能不正常的乙肝“小三阳”的治疗。

CT扫描增患癌风险 儿童更易受伤害

美国一份最新研究报告警告说，医生在诊疗过程中对于CT扫描技术的滥用导致两千多万美国人特别是儿童，遭受不必要的“超强X光”的辐射，使得他们面临更高的患癌风险。CT扫描辐射致癌率达2％。这项研究报告由埃里克·赫尔和美国哥伦比亚大学医学物理师大卫·勃伦钠共同完成，已在出版的《新英格兰医学杂志》上发表，

烟草损害健康 低焦油不等于低危害

吸烟有害健康已广为所知，为健康而拒绝吸烟的人越多越多，烟草企业为了推销烟草，目前普遍宣传“低焦油卷烟危害低、致癌率低”，对此，权威专家明确表示，低焦油不等于低危害，没有任何烟草产品是安全的。西方烟草公司在上世纪中期推出了低焦油和淡味的卷烟，其名称来源于用吸烟机器测试时，

Role of cyclooxygenase-2 gene polymorphisms in pancreatic carcinogenesis

AIM:To evaluate the clinical significance of-765G/C and-1195G/A cyclooxygenase-2 (COX-2) gene polymorphisms in patients with pancreatic cancer (PC).METHODS:The study included 201 patients:85 with PC and 116 healthy controls.-765G/C and-1195G/A COX-2 gene polymorphisms were studied in DNA isolated from blood samples.The associations of the analyzed genotypes and clinical data at diagnosis were evaluated.RESULTS:We found an increased frequency of the homozygous-1195AA COX-2 genotype in patients with PC (53.7%) compared with the control group (21%) (P < 0.01).In contrast,the distribution of genotypeand allele frequencies of the-765G/C COX-2 polymorphism in the PC patients were not different from those in control groups.A correlation between presence of homozygous-1195AA COX-2 genotype and tumor size > 3 cm was observed (P < 0.05).Analyzed polymorphisms were unrelated to the patients' sex and age,nor to the presence of regional or distant metastases.CONCLUSION:These preliminary results indicate that the-1195G/A COX-2 polymorphism may play an important role in PC prognosis and carcinogenesis.