Studies of the mechanism of HIV entry and transmission have identified multiple new targets for drug development. A range of inhibitors have demonstrated potent antiretroviral activity by interfering with CD4-gp120 in...Studies of the mechanism of HIV entry and transmission have identified multiple new targets for drug development. A range of inhibitors have demonstrated potent antiretroviral activity by interfering with CD4-gp120 interaction,coreceptor binding or viral-cell fusion in preclinical and clinical studies. One of these agents,fusion inhibitor enfuvirtide,is already in clinical use. Here we review the progress in the development of specific entry inhibitors as novel therapeutics. The potential of entry inhibitors as topical microbicides to block HIV transmission is also discussed.展开更多
On the 29th World AIDS Day on December 1,when various activities were held nationwide to disseminate information on HIV/AIDS-related issues,participants hugged and shook hands with other participants living with HIV/A...On the 29th World AIDS Day on December 1,when various activities were held nationwide to disseminate information on HIV/AIDS-related issues,participants hugged and shook hands with other participants living with HIV/AIDS,providing a striking contrast to the early days when the diagnosis of AIDS often created panic and people’s first reactionwastoostracizeHIV／AIDSpatients．展开更多
基金NIH (AI065413 and AI041346)the 973 Program (2006CB504200) for financial support.
文摘Studies of the mechanism of HIV entry and transmission have identified multiple new targets for drug development. A range of inhibitors have demonstrated potent antiretroviral activity by interfering with CD4-gp120 interaction,coreceptor binding or viral-cell fusion in preclinical and clinical studies. One of these agents,fusion inhibitor enfuvirtide,is already in clinical use. Here we review the progress in the development of specific entry inhibitors as novel therapeutics. The potential of entry inhibitors as topical microbicides to block HIV transmission is also discussed.
文摘On the 29th World AIDS Day on December 1,when various activities were held nationwide to disseminate information on HIV/AIDS-related issues,participants hugged and shook hands with other participants living with HIV/AIDS,providing a striking contrast to the early days when the diagnosis of AIDS often created panic and people’s first reactionwastoostracizeHIV／AIDSpatients．
