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论非歧视原则是艾滋病法的首要原则 被引量:6
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作者 任元鹏 姜柏生 《医学与社会》 2011年第2期81-83,共3页
歧视是艾滋病环境中最严重的违反人权的行为。艾滋病歧视主要表现为直接歧视、间接歧视和制度歧视,严重影响到艾滋病的防治工作。对艾滋病歧视的主要原因在于人们对艾滋病的认识不足等方面。确立非歧视原则作为艾滋病法的首要原则,就是... 歧视是艾滋病环境中最严重的违反人权的行为。艾滋病歧视主要表现为直接歧视、间接歧视和制度歧视,严重影响到艾滋病的防治工作。对艾滋病歧视的主要原因在于人们对艾滋病的认识不足等方面。确立非歧视原则作为艾滋病法的首要原则,就是要求在本质上实现人人平等,才能影响和制约着艾滋病防治过程中的其他原则。 展开更多
关键词 艾滋病歧视 非歧视原则 艾滋病法
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江苏省出台地方艾滋病法
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作者 苏防 《农家致富》 2004年第18期52-52,共1页
关键词 江苏 艾滋病法 感染者 就学 结婚
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PHASE-1 STUDIES OF MALARIOTHERAPY FOR HIV INFECTON 被引量:5
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作者 陈小平 HenryJ.Heimlich +4 位作者 肖斌权 刘树国 卢月恒 饶纪礼 EricG.Spletzer 《Chinese Medical Sciences Journal》 CAS CSCD 1999年第4期224-228,共5页
Objective. To determine whether malariotherapy (an old therapy for treatment of neurosyphilis) improves some clinical and laboratory parameters of HIV positive patients without iatrogenic compl... Objective. To determine whether malariotherapy (an old therapy for treatment of neurosyphilis) improves some clinical and laboratory parameters of HIV positive patients without iatrogenic complications. Methods. Total 8 asymptomatic HIV 1 positive subjects whose CD4 cell counts were over 250×10 6 cells/L were selected for the phase 1 studies of malariotherapy and were intravenously injected Plasmodia vivax to induce artificial malaria. Malaria was terminated with chloroquine after 10~20 malarial fever episodes. Cell bound CD4 levels were measured by APAAP (a solid phase enzyme essay) and levels of neopterin (NPT), beta 2 microglobulin (B2M), soluble tumor necrosis factor receptor 2(sTNF RII), interleukin 2(IL 2) and HIV P24 antigen were measured by ELISA. Patients were followed up to 24~30 months. Results.CD4 levels increased in 5, NPT decreased in 7 of 8 patients; IL 2 increased in 5 of 6 patients after malariotherapy. The total trends of B2M and sTNF RII basically remained stable. HIV P24 antigen remained undetectable in 6, remained detectably low level in 1 and experienced increase in 1 of 8 patients after malariotherapy. No any severe complications occurred in all 8 patients. Conclusions. The results indicate that malariotherapy basically is safe for HIV infection and it seems that the therapy improves some immunological parameters of HIV patients. 展开更多
关键词 malariotherapy HIV AIDS
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Impact of human immunodeficiency virus infection on the course of hepatitis C virus infection: A meta-analysis 被引量:11
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作者 Li-Ping Deng Xi-En Gui Yong-Xi Zhang Shi-Cheng Gao Rong-Rong Yang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第8期996-1003,共8页
AIM: To analyze the influence of human immunodeficiency virus (HIV) infection on the course of hepatitis C virus (HCV) infection. METHODS: We performed a meta-analysis to quantify the effect of HIV co-infection on pro... AIM: To analyze the influence of human immunodeficiency virus (HIV) infection on the course of hepatitis C virus (HCV) infection. METHODS: We performed a meta-analysis to quantify the effect of HIV co-infection on progressive liver disease in patients with HCV infection. Published studies in the English or Chinese-language medical literature involving cohorts of HIV-negative and -positive patients coinfected with HCV were obtained by searching the PUBMED, EMBASE and CBM. Data were extracted independently from relevant studies by 2 investigators and used in a fixed-effect meta analysis to determine the difference in the course of HCV infection in the 2 groups. RESULTS: Twenty-nine trails involving 16 750 patients were identified including the outcome of histological fibrosis or cirrhosis or de-compensated liver disease or hepatocellular carcinoma or death. These studies yielded a combined adjusted odds ratio (OR) of 3.40 [95% confidence interval (CI) = 2.45 and 4.73]. Of note, studies that examined histological fibrosis/ cirrhosis, decompensated liver disease, hepatocellular carcinoma or death had a pooled OR of 1.47 (95% CI = 1.27 and 1.70), 5.45 (95% CI = 2.54 and 11.71), 0.76 (95% CI = 0.50 and 1.14), and 3.60 (95% CI = 3.12 and 4.15), respectively. CONCLUSION: Without highly active antiretroviral therapies (HAART), HIV accelerates HCV diseaseprogression, including death, histological fibrosis/ cirrhosis and decompensated liver disease. However, the rate of hepatocellular carcinoma is similar in persons who had HCV infection and were positive for HIV or negative for HIV. 展开更多
关键词 Human immunodeficiency virus Hepatitis C virus COINFECTION Disease progression META-ANALYSIS
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Construction and expression of the bicistronic expression vector with RANTES and SDF-1 genes
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作者 张颖 白雪帆 +4 位作者 李谨革 黄长形 孙永涛 聂青和 王九平 《Journal of Medical Colleges of PLA(China)》 CAS 2003年第6期369-372,共4页
Objective: To construct bicistronic expression vector with RANTES and SDF-1 genes, the ligands of HIV-1 principal coreceptors, and identify its expression. Methods: RANTES-KDEL was amplified from plasmid pCMV-R-K by P... Objective: To construct bicistronic expression vector with RANTES and SDF-1 genes, the ligands of HIV-1 principal coreceptors, and identify its expression. Methods: RANTES-KDEL was amplified from plasmid pCMV-R-K by PCR and cloned into eukaryotic expression vector pCMV-S/K. Gene transfection into HeLa cells was carried out by lipofectin. Indirect immumofluorescence and radioimmunoprecipitation were used to confirm the expression of RANTES and SDF-1. Results: The construction of pCMV-R-K-S-K was confirmed by enzymatic digestion and sequencing. RANTES and SDF-1 were shown expressed in HeLa cells by indirect immumofluorescence and radioimmunoprecipitation. Conclusion: pCMV-R-K-S-K was constructed and expressed in cell line Hela successfully, which will contribute to further study of gene therapy of AIDS by HIV-1 coreceptors knockout. 展开更多
关键词 HIV-1 CORECEPTOR CHEMOKINE bicistronic expression vector TRANSFECTION indirect immumofluorescence radioimmunoprecipitation
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