Chemical constituents of the leaves of Artemisia argyi were investigated. By using a variety of chromatographic techniques and spectroscopic methods, six compounds were isolated and identified as follows： clemaphenol...Chemical constituents of the leaves of Artemisia argyi were investigated. By using a variety of chromatographic techniques and spectroscopic methods, six compounds were isolated and identified as follows： clemaphenol A （1）, aurantiamide acetate （2）, camelliagenin A （3）, japonica acid （4）, labd-13（E）-ene-8α,15-diol （5）, and 313-acetoxy-20-oxo-21-nordammaran-23-oic acid （6）. Among these products, compounds 1 and 3-6 were obtained from the genus Artemisia for the first time and compound 2 was firstly reported from the species. Additionally, compound 5 displayed an inhibitory effect against the lipopolysaccharide （LPS）-induced nitric oxide （NO） production in BV-2 microglial cells with an IC50 value of 6.68 μM.展开更多
Implementing clinical trials with large multicenter samples is an important way to scientifically evaluate and demonstrate the curative effect of moxibustion.At present,clinical trials on moxibustion with large multic...Implementing clinical trials with large multicenter samples is an important way to scientifically evaluate and demonstrate the curative effect of moxibustion.At present,clinical trials on moxibustion with large multicenter samples are prospering in China.It is necessary for research units to have good research professionals and technical platforms as well as a highly standardized and scientifically feasible methodology of research.Taking tasks in the ongoing national 973 project and in the sci-tech support program of the "11th 5-year plan",for example,this research captures the characteristics of moxibustion,carries out deep analysis and introduces specific methods and the important significance of clinical research tasks on moxibustion in designing multicenter plans,implementing experiments,supervising quality and strengthening compliance.展开更多
基金National Natural Science Foundation of China(Grant No. 30973629)
文摘Chemical constituents of the leaves of Artemisia argyi were investigated. By using a variety of chromatographic techniques and spectroscopic methods, six compounds were isolated and identified as follows： clemaphenol A （1）, aurantiamide acetate （2）, camelliagenin A （3）, japonica acid （4）, labd-13（E）-ene-8α,15-diol （5）, and 313-acetoxy-20-oxo-21-nordammaran-23-oic acid （6）. Among these products, compounds 1 and 3-6 were obtained from the genus Artemisia for the first time and compound 2 was firstly reported from the species. Additionally, compound 5 displayed an inhibitory effect against the lipopolysaccharide （LPS）-induced nitric oxide （NO） production in BV-2 microglial cells with an IC50 value of 6.68 μM.
基金Supported by the National "11th 5-year Plan" (2006BAI12B04-2)National Plan on Developing Key Basic Researches(973 Plan)(2009CB522902)+1 种基金State Natural Science Fund(30760320)a project of Key Sci-tech Support Plan in Jiangxi
文摘Implementing clinical trials with large multicenter samples is an important way to scientifically evaluate and demonstrate the curative effect of moxibustion.At present,clinical trials on moxibustion with large multicenter samples are prospering in China.It is necessary for research units to have good research professionals and technical platforms as well as a highly standardized and scientifically feasible methodology of research.Taking tasks in the ongoing national 973 project and in the sci-tech support program of the "11th 5-year plan",for example,this research captures the characteristics of moxibustion,carries out deep analysis and introduces specific methods and the important significance of clinical research tasks on moxibustion in designing multicenter plans,implementing experiments,supervising quality and strengthening compliance.
