Several methods of mixed programming with LabVIEW and Matlab are introduced.Taking explosin test as application background,the design method and implementation process using MathScript node and COM technology are main...Several methods of mixed programming with LabVIEW and Matlab are introduced.Taking explosin test as application background,the design method and implementation process using MathScript node and COM technology are mainly discussed.Based on this,the advantages of LabVIEW's interface development and Matlab's rich data operation functions are combined to achieve the fitting of explosion pressure field and dynamic compensation of temperature measured.展开更多
The effects of different yaw angles on the aerodynamic performance of city electric multiple units(EMUs)were investigated in a wind tunnel using a 1:16.8 scaled model.Pressure scanning valve and six-component box-type...The effects of different yaw angles on the aerodynamic performance of city electric multiple units(EMUs)were investigated in a wind tunnel using a 1:16.8 scaled model.Pressure scanning valve and six-component box-type aerodynamic balance were used to test the pressure distribution and aerodynamic force of the head car respectively from the 1.5-and 3-coach grouping city EMU models.Meanwhile,the effects of the yaw angles on the pressure distribution of the streamlined head as well as the aerodynamic forces of the train were analyzed.The experimental results showed that the pressure coefficient was the smallest at the maximum slope of the main shape-line.The side force coefficient and pressure coefficient along the head car cross-section were most affected by crosswind when the yaw angle was 55°,and replacing a 3-coach grouping with a 1.5-coach grouping had obvious advantages for wind tunnel testing when the yaw angle was within 24.2°.In addition,the relative errors of lift coefficient C_(L),roll moment coefficient C_(Mx),side force coefficient C_(S),and drag coefficient C_(D) between the 1.5-and 3-coach cases were below 5.95%,which all met the requirements of the experimental accuracy.展开更多
A new Network Coding mechanism in WSNs(Wireless Sensor Networks), which is named COEQ and aims at balancing coding opportunities, energy and QoS, is proposed and analyzed. Implemented on the basis of traditional AODV ...A new Network Coding mechanism in WSNs(Wireless Sensor Networks), which is named COEQ and aims at balancing coding opportunities, energy and QoS, is proposed and analyzed. Implemented on the basis of traditional AODV protocol, COEQ evaluates several metrics of paths comprehensively with TOPSIS method including minimum remaining energy, coding opportunities, QoS and so on, so as to select the optimal transmitting route. Experiments on NS[2] show that COEQ can improve throughput and save energy when the transmitting rate is low.展开更多
The totally coded method (TCM) reveal the same law which governing the gain calculating for signal flow graph as Mason formula does. This algorithm is carried out merely in the domain of code operation. Based on pure ...The totally coded method (TCM) reveal the same law which governing the gain calculating for signal flow graph as Mason formula does. This algorithm is carried out merely in the domain of code operation. Based on pure code algorithm, it is more efficiency because any figure searching is no longer necessary. The code-series (CS), which are organized from node association table, have the holo-information nature, so that both the content and the sign of each gain-term can be determined via the coded method. The principle of this method is obvious and it is suited for computer programming. The capability of the computer-aided analysis for the active network, such as operation amplifier network, can be enhanced.展开更多
An energy-saving algorithm for wireless sensor networks based on network coding and compressed sensing (CS-NCES) is proposed in this paper. Along with considering the correlations of data spatial and temporal, the a...An energy-saving algorithm for wireless sensor networks based on network coding and compressed sensing (CS-NCES) is proposed in this paper. Along with considering the correlations of data spatial and temporal, the algorithm utilizes the similarities between the encoding matrix of network coding and the measurement matrix of compressed sensing. The source node firstly encodes the data, then compresses the coding data by cot-npressed sensing over finite fields. Compared with the network coding scheme, simulation results show that CS-NCES reduces the energy consumption about 25.30/0-34.50/0 and improves the efficiency of data reconstruction about 1.56%- 5.98%. The proposed algorithm can not only enhance the usability of network coding in wireless sensor networks, but also improve the network performance.展开更多
A method for formation flight trajectory optimization was established.This method aims at minimizing fuel consumption of a two-aircraft formation flight,without changing the original trajectory of the leader.Candidate...A method for formation flight trajectory optimization was established.This method aims at minimizing fuel consumption of a two-aircraft formation flight,without changing the original trajectory of the leader.Candidate flight pairs were selected from all international flights arriving at or departing from China in one day according to the requirement of the proposed method.Aircraft performance database Base of Aircraft Data(BADA)was employed in the trajectory computation.By assuming different fuel-saving percentages for the following aircraft,pre-flight plan trajectories of formation flight were optimized.The fuel consumption optimization effect under the influence of different trajectory optimization parameters was also analyzed.The results showed that the higher the fuel savings percentage,the longer the flight distance of formation flight,but the smaller the number of formation combinations that can be realized,which is limited by the aircraft performance.The following aircraft flying along the approximate actual flight trajectory can be benefited as well,and the optimal fuel-saving efficiency is related to the expected fuelsaving efficiency of formation flight.展开更多
The paper explores applications of genetic programming to co-evolution of morphology and low-level control. In most reasonably difficult tasks, facilitation provided by modularity has proved to be vital for successful...The paper explores applications of genetic programming to co-evolution of morphology and low-level control. In most reasonably difficult tasks, facilitation provided by modularity has proved to be vital for successful application of genetic programming. However, the need for sharing data among nodes in the syntactic tree becomes especially acute when evolving modular programs. It has been shown before that it may be beneficial that modules themselves be node-attached. The paper presents extensions to standard genetic programming (the so-called contexts and context blocks) that allow for straight-forward storage, retrieval, transfer, and modification of data stored in the context of a syntactic tree, and shared by multiple nodes. Framework is thus provided for both: data sharing and node-attached modules. Finally, using context blocks, a genetic algorithm has been embedded within genetic programming to evolve values of constants. In genetic programming evolution of constants has been a long-standing problem. The paper shows how context blocks can be utilized to provide a more granular and flexible approach to their evolution. As shown in previous works, node-attached modules perform favorably when compared with existing approaches. Concerning evolution of context block constants, it is shown here that they too perform favorably when compared with ephemeral constants.展开更多
The paper addresses the disconnected students experience between evaluating their own writing and traditional evaluation methods, despite effective discussion and analysis in the classroom, especially, wide when stude...The paper addresses the disconnected students experience between evaluating their own writing and traditional evaluation methods, despite effective discussion and analysis in the classroom, especially, wide when students' reading skills are limited. The paper considers the application of flipping students' intense interest and intimate comprehension of video gaming into a lens for evaluating their writing. The sophisticated storylines in some literacy-laden video games rivet students' attention in higher order applications while the intricate plots and characters mirror those literary elements taught in print media. Garner comprehension is demandingly complex; transferring literary elements from the game storyline to their writing provides the comprehension carry-over for effective self-evaluation. They can "see" as a metaphor, those parallel concepts from screen to print, from playing strengths to reading and writing, for them, literary qualities become more transparent, and thus more accessible.展开更多
Wireless sensor-actuator networks can bring flexibility to smart home.We design and develop a smart home prototype using wireless sensor-actuator network technology to realize environmental sensing and the control of ...Wireless sensor-actuator networks can bring flexibility to smart home.We design and develop a smart home prototype using wireless sensor-actuator network technology to realize environmental sensing and the control of electric appliances.The basic motivation of our solution is to utilize the collaboration among a mass of low-cost sensor nodes and actuator nodes to make life convenient.To achieve it,we design a novel system architecture with assembled component modules.In particular,we address some key technical challenges:1) Field-Programmable Gate Array (FPGA) Implementation of Adaptive Differential Pulse Code Modulation (ADPCM) for audio data;2) FPGA Implementation of Lempel Ziv Storer Szymanski (LZSS) for bulk data;3) combination of complex control logic.Finally,a set of experiments are presented to evaluate the performance of our solution.展开更多
In recent years the variety and complexity of Wireless Sensor Network (WSN) applications, the nodes and the functions they are expected to perform have increased immensely. This poses the question of reducing the ti...In recent years the variety and complexity of Wireless Sensor Network (WSN) applications, the nodes and the functions they are expected to perform have increased immensely. This poses the question of reducing the time from initial design of WSN applications to their implementation as a major research topic. RF communication programs for WSN nodes are generally written on microcontroller units (MCUs) for universal asynchronous receiver/transmitter (UART) data communication, however nowadays radio frequency (RF) designs based on field-programmable gate array (FPGA) have emerged as a very powerful alternative, due to their parallel data processing ability and software reconfigurability. In this paper, the authors present a prototype of a flexible multi-node transceiver and monitoring system. The prototype is designed for time-critical applications and can be also reconfigured for other applications like event tracking. The processing power of FPGA is combined with a simple communication protocol. The system consists of three major parts: wireless nodes, the FPGA and display used for visualization of data processing. The transmission protocol is based on preamble and synchronous data transmission, where the receiver adjusts the receiving baud rate in the range from min. 300 to max. 2400 bps. The most important contribution of this work is using the virtual PicoBlaze Soft-Core Processor for controlling the data transmission through the RF modules. The proposed system has been evaluated based on logic utilization, in terms of the number of slice flip flops, the number of 4 input LUTs (Look-Up Tables) and the number of bonded lOBs (Input Output Blocks). The results for capacity usage are very promising as compared to other similar research.展开更多
Viral microRNAs are one component of the RNA interference phenomenon generated during viral infection. They were first identified in the Herpesviridae family, where they were found to regulate viral mRNA translation. ...Viral microRNAs are one component of the RNA interference phenomenon generated during viral infection. They were first identified in the Herpesviridae family, where they were found to regulate viral mRNA translation. In addition, prior work has suggested that Kaposi's sarcoma-associated herpesvirus (KSHV) is capable of regulating cellular gene transcription by miRNA. We demonstrate that a miRNA, hsvl-mir-H27, encoded within the genome of herpes simplex virus 1 (HSV-1), targets the mRNA of the cellular transcriptional repressor Kelch-like 24 (KLHL24) that inhibits transcriptional efficiency of viral imme- diate-early and early genes. The viral miRNA is able to block the expression of KLHL24 in cells infected by HSV-1. Our dis- covery reveals an effective viral strategy for evading host cell defenses and supporting the efficient replication and prolifera- tion of HSV- 1.展开更多
Effective treatment of rheumatoid arthritis can be mediated by native chicken type II collagen(n CCII), recombinant peptide containing n CCII tolerogenic epitopes(CTEs), or a therapeutic DNA vaccine encoding the full-...Effective treatment of rheumatoid arthritis can be mediated by native chicken type II collagen(n CCII), recombinant peptide containing n CCII tolerogenic epitopes(CTEs), or a therapeutic DNA vaccine encoding the full-length CCOL2 A1 c DNA. As recombinant CCII(r CCII) might avoid potential pathogenic virus contamination during n CCII preparation or chromosomal integration and oncogene activation associated with DNA vaccines, here we evaluated the importance of propeptide and telopeptide domains on r CCII triple helix molecular assembly. We constructed p C-and p N-procollagen(without N-or Cpropeptides, respectively) as well as CTEs located in the triple helical domain lacking both propeptides and telopeptides, and expressed these in yeast Pichia pastoris host strain GS115(his4, Mut+) simultaneously with recombinant chicken prolyl-4-hydroxylase α and β subunits. Both p C-and p N-procollagen monomers accumulated inside P. pastoris cells, whereas CTE was assembled into homotrimers with stable conformation and secreted into the supernatants, suggesting that the large molecular weight p C-or p N-procollagens were retained within the endoplasmic reticulum whereas the smaller CTEs proceeded through the secretory pathway. Furthermore, resulting recombinant chicken type II collagen p Cα1(II) can induce collagen-induced arthritis(CIA) rat model, which seems to be as effective as the current standard n CCII. Notably, protease digestion assays showed that r CCII could assemble in the absence of C-and N-propeptides or telopeptides. These findings provide new insights into the minimal structural requirements for r CCII expression and folding.展开更多
Triple-negative breast cancer(TNBC)is currently the most malignant subtype of breast cancer without effective targeted therapies,which makes its pathogenesis an important target for research.A growing number of studie...Triple-negative breast cancer(TNBC)is currently the most malignant subtype of breast cancer without effective targeted therapies,which makes its pathogenesis an important target for research.A growing number of studies have shown that non-coding RNA(ncRNA),including microRNA(miRNA)and long non-coding RNA(lncRNA),plays a significant role in tumorigenesis.This review summarizes the roles of miRNA and lncRNA in the progression,diagnosis,and neoadjuvant chemotherapy of TNBC.Aberrantly expressed miRNA and lncRNA are listed according to their roles.Further,it describes the multiple mechanisms that lncRNA shows for regulating gene expression in the nucleus and cytoplasm,and more importantly,describes lnc RNA-regulated TNBC progression through complete combining with miRNA at the post-transcriptional level.Focusing on miRNA and lncRNA associated with TNBC can provide new insights for early diagnosis and treatment—they can be targeted in the future as a novel anticancer target of TNBC.展开更多
文摘Several methods of mixed programming with LabVIEW and Matlab are introduced.Taking explosin test as application background,the design method and implementation process using MathScript node and COM technology are mainly discussed.Based on this,the advantages of LabVIEW's interface development and Matlab's rich data operation functions are combined to achieve the fitting of explosion pressure field and dynamic compensation of temperature measured.
基金Project(2020YFA0710903) supported by the National Key R&D Program of ChinaProjects(2020zzts111, 2020zzts117)supported by the Graduate Student Independent Innovation Project of Central South University,ChinaProject(202037)supported by Transport Department of Hunan Province Technology Innovation Project,China。
文摘The effects of different yaw angles on the aerodynamic performance of city electric multiple units(EMUs)were investigated in a wind tunnel using a 1:16.8 scaled model.Pressure scanning valve and six-component box-type aerodynamic balance were used to test the pressure distribution and aerodynamic force of the head car respectively from the 1.5-and 3-coach grouping city EMU models.Meanwhile,the effects of the yaw angles on the pressure distribution of the streamlined head as well as the aerodynamic forces of the train were analyzed.The experimental results showed that the pressure coefficient was the smallest at the maximum slope of the main shape-line.The side force coefficient and pressure coefficient along the head car cross-section were most affected by crosswind when the yaw angle was 55°,and replacing a 3-coach grouping with a 1.5-coach grouping had obvious advantages for wind tunnel testing when the yaw angle was within 24.2°.In addition,the relative errors of lift coefficient C_(L),roll moment coefficient C_(Mx),side force coefficient C_(S),and drag coefficient C_(D) between the 1.5-and 3-coach cases were below 5.95%,which all met the requirements of the experimental accuracy.
基金supported by the Chinese National Natural Science Foundation(No:61070204,61101108)Funding Project for Academic Human Resources Development in Institutions of Higher Learning Under the Jurisdiction of Beijing Municipality(11530500015)
文摘A new Network Coding mechanism in WSNs(Wireless Sensor Networks), which is named COEQ and aims at balancing coding opportunities, energy and QoS, is proposed and analyzed. Implemented on the basis of traditional AODV protocol, COEQ evaluates several metrics of paths comprehensively with TOPSIS method including minimum remaining energy, coding opportunities, QoS and so on, so as to select the optimal transmitting route. Experiments on NS[2] show that COEQ can improve throughput and save energy when the transmitting rate is low.
文摘The totally coded method (TCM) reveal the same law which governing the gain calculating for signal flow graph as Mason formula does. This algorithm is carried out merely in the domain of code operation. Based on pure code algorithm, it is more efficiency because any figure searching is no longer necessary. The code-series (CS), which are organized from node association table, have the holo-information nature, so that both the content and the sign of each gain-term can be determined via the coded method. The principle of this method is obvious and it is suited for computer programming. The capability of the computer-aided analysis for the active network, such as operation amplifier network, can be enhanced.
文摘An energy-saving algorithm for wireless sensor networks based on network coding and compressed sensing (CS-NCES) is proposed in this paper. Along with considering the correlations of data spatial and temporal, the algorithm utilizes the similarities between the encoding matrix of network coding and the measurement matrix of compressed sensing. The source node firstly encodes the data, then compresses the coding data by cot-npressed sensing over finite fields. Compared with the network coding scheme, simulation results show that CS-NCES reduces the energy consumption about 25.30/0-34.50/0 and improves the efficiency of data reconstruction about 1.56%- 5.98%. The proposed algorithm can not only enhance the usability of network coding in wireless sensor networks, but also improve the network performance.
基金This work was supported by the National Natural Science Foundation of China(No.U1633109)the Fundamental Research Funds for the Central Universities(No.3122016C010).
文摘A method for formation flight trajectory optimization was established.This method aims at minimizing fuel consumption of a two-aircraft formation flight,without changing the original trajectory of the leader.Candidate flight pairs were selected from all international flights arriving at or departing from China in one day according to the requirement of the proposed method.Aircraft performance database Base of Aircraft Data(BADA)was employed in the trajectory computation.By assuming different fuel-saving percentages for the following aircraft,pre-flight plan trajectories of formation flight were optimized.The fuel consumption optimization effect under the influence of different trajectory optimization parameters was also analyzed.The results showed that the higher the fuel savings percentage,the longer the flight distance of formation flight,but the smaller the number of formation combinations that can be realized,which is limited by the aircraft performance.The following aircraft flying along the approximate actual flight trajectory can be benefited as well,and the optimal fuel-saving efficiency is related to the expected fuelsaving efficiency of formation flight.
文摘The paper explores applications of genetic programming to co-evolution of morphology and low-level control. In most reasonably difficult tasks, facilitation provided by modularity has proved to be vital for successful application of genetic programming. However, the need for sharing data among nodes in the syntactic tree becomes especially acute when evolving modular programs. It has been shown before that it may be beneficial that modules themselves be node-attached. The paper presents extensions to standard genetic programming (the so-called contexts and context blocks) that allow for straight-forward storage, retrieval, transfer, and modification of data stored in the context of a syntactic tree, and shared by multiple nodes. Framework is thus provided for both: data sharing and node-attached modules. Finally, using context blocks, a genetic algorithm has been embedded within genetic programming to evolve values of constants. In genetic programming evolution of constants has been a long-standing problem. The paper shows how context blocks can be utilized to provide a more granular and flexible approach to their evolution. As shown in previous works, node-attached modules perform favorably when compared with existing approaches. Concerning evolution of context block constants, it is shown here that they too perform favorably when compared with ephemeral constants.
文摘The paper addresses the disconnected students experience between evaluating their own writing and traditional evaluation methods, despite effective discussion and analysis in the classroom, especially, wide when students' reading skills are limited. The paper considers the application of flipping students' intense interest and intimate comprehension of video gaming into a lens for evaluating their writing. The sophisticated storylines in some literacy-laden video games rivet students' attention in higher order applications while the intricate plots and characters mirror those literary elements taught in print media. Garner comprehension is demandingly complex; transferring literary elements from the game storyline to their writing provides the comprehension carry-over for effective self-evaluation. They can "see" as a metaphor, those parallel concepts from screen to print, from playing strengths to reading and writing, for them, literary qualities become more transparent, and thus more accessible.
基金supported by the Natural Science Foundation of China under Grant No.61070206,No.61070205and No.60833009the National973Project of China under Grant No.2011CB302701+2 种基金the program of New Century Excellent Talents in University of China under Grant No.NCET-080737the Beijing National Natural Science Foundation under Grant No.4092030the Cosponsored Project of Beijing Committee of Education
文摘Wireless sensor-actuator networks can bring flexibility to smart home.We design and develop a smart home prototype using wireless sensor-actuator network technology to realize environmental sensing and the control of electric appliances.The basic motivation of our solution is to utilize the collaboration among a mass of low-cost sensor nodes and actuator nodes to make life convenient.To achieve it,we design a novel system architecture with assembled component modules.In particular,we address some key technical challenges:1) Field-Programmable Gate Array (FPGA) Implementation of Adaptive Differential Pulse Code Modulation (ADPCM) for audio data;2) FPGA Implementation of Lempel Ziv Storer Szymanski (LZSS) for bulk data;3) combination of complex control logic.Finally,a set of experiments are presented to evaluate the performance of our solution.
文摘In recent years the variety and complexity of Wireless Sensor Network (WSN) applications, the nodes and the functions they are expected to perform have increased immensely. This poses the question of reducing the time from initial design of WSN applications to their implementation as a major research topic. RF communication programs for WSN nodes are generally written on microcontroller units (MCUs) for universal asynchronous receiver/transmitter (UART) data communication, however nowadays radio frequency (RF) designs based on field-programmable gate array (FPGA) have emerged as a very powerful alternative, due to their parallel data processing ability and software reconfigurability. In this paper, the authors present a prototype of a flexible multi-node transceiver and monitoring system. The prototype is designed for time-critical applications and can be also reconfigured for other applications like event tracking. The processing power of FPGA is combined with a simple communication protocol. The system consists of three major parts: wireless nodes, the FPGA and display used for visualization of data processing. The transmission protocol is based on preamble and synchronous data transmission, where the receiver adjusts the receiving baud rate in the range from min. 300 to max. 2400 bps. The most important contribution of this work is using the virtual PicoBlaze Soft-Core Processor for controlling the data transmission through the RF modules. The proposed system has been evaluated based on logic utilization, in terms of the number of slice flip flops, the number of 4 input LUTs (Look-Up Tables) and the number of bonded lOBs (Input Output Blocks). The results for capacity usage are very promising as compared to other similar research.
基金supported by the National Natural Science Foundation of China (30670094, 30700028)National Basic Research Program of China (2012CB518901, 2011CB504903)
文摘Viral microRNAs are one component of the RNA interference phenomenon generated during viral infection. They were first identified in the Herpesviridae family, where they were found to regulate viral mRNA translation. In addition, prior work has suggested that Kaposi's sarcoma-associated herpesvirus (KSHV) is capable of regulating cellular gene transcription by miRNA. We demonstrate that a miRNA, hsvl-mir-H27, encoded within the genome of herpes simplex virus 1 (HSV-1), targets the mRNA of the cellular transcriptional repressor Kelch-like 24 (KLHL24) that inhibits transcriptional efficiency of viral imme- diate-early and early genes. The viral miRNA is able to block the expression of KLHL24 in cells infected by HSV-1. Our dis- covery reveals an effective viral strategy for evading host cell defenses and supporting the efficient replication and prolifera- tion of HSV- 1.
文摘Effective treatment of rheumatoid arthritis can be mediated by native chicken type II collagen(n CCII), recombinant peptide containing n CCII tolerogenic epitopes(CTEs), or a therapeutic DNA vaccine encoding the full-length CCOL2 A1 c DNA. As recombinant CCII(r CCII) might avoid potential pathogenic virus contamination during n CCII preparation or chromosomal integration and oncogene activation associated with DNA vaccines, here we evaluated the importance of propeptide and telopeptide domains on r CCII triple helix molecular assembly. We constructed p C-and p N-procollagen(without N-or Cpropeptides, respectively) as well as CTEs located in the triple helical domain lacking both propeptides and telopeptides, and expressed these in yeast Pichia pastoris host strain GS115(his4, Mut+) simultaneously with recombinant chicken prolyl-4-hydroxylase α and β subunits. Both p C-and p N-procollagen monomers accumulated inside P. pastoris cells, whereas CTE was assembled into homotrimers with stable conformation and secreted into the supernatants, suggesting that the large molecular weight p C-or p N-procollagens were retained within the endoplasmic reticulum whereas the smaller CTEs proceeded through the secretory pathway. Furthermore, resulting recombinant chicken type II collagen p Cα1(II) can induce collagen-induced arthritis(CIA) rat model, which seems to be as effective as the current standard n CCII. Notably, protease digestion assays showed that r CCII could assemble in the absence of C-and N-propeptides or telopeptides. These findings provide new insights into the minimal structural requirements for r CCII expression and folding.
基金Project supported by the Zhejiang Provincial Natural Science Foundation of China(No.LY18C050006)the Key Research and Development Project of Zhejiang Province(No.2020C02039)。
文摘Triple-negative breast cancer(TNBC)is currently the most malignant subtype of breast cancer without effective targeted therapies,which makes its pathogenesis an important target for research.A growing number of studies have shown that non-coding RNA(ncRNA),including microRNA(miRNA)and long non-coding RNA(lncRNA),plays a significant role in tumorigenesis.This review summarizes the roles of miRNA and lncRNA in the progression,diagnosis,and neoadjuvant chemotherapy of TNBC.Aberrantly expressed miRNA and lncRNA are listed according to their roles.Further,it describes the multiple mechanisms that lncRNA shows for regulating gene expression in the nucleus and cytoplasm,and more importantly,describes lnc RNA-regulated TNBC progression through complete combining with miRNA at the post-transcriptional level.Focusing on miRNA and lncRNA associated with TNBC can provide new insights for early diagnosis and treatment—they can be targeted in the future as a novel anticancer target of TNBC.