芯粒集成逐渐成为不同场景下敏捷定制深度学习芯片的高可扩展性的解决方案,芯片设计者可以通过集成设计、验证完成的第三方芯粒来降低芯片开发周期和成本,提高芯片设计的灵活性和芯片良率.在传统的芯片设计和商业模式中,编译器等专用软...芯粒集成逐渐成为不同场景下敏捷定制深度学习芯片的高可扩展性的解决方案,芯片设计者可以通过集成设计、验证完成的第三方芯粒来降低芯片开发周期和成本,提高芯片设计的灵活性和芯片良率.在传统的芯片设计和商业模式中,编译器等专用软件工具链是芯片解决方案的组成部分,并在芯片性能和开发中发挥重要作用.然而,当使用第三方芯粒进行芯片敏捷定制时,第三方芯粒所提供的专用工具链无法预知整个芯片的资源,因此无法解决敏捷定制的深度学习芯片的任务部署问题,而为敏捷定制的芯片设计全新的工具链需要大量的时间成本,失去了芯片敏捷定制的优势.因此,提出一种面向深度学习集成芯片的可扩展框架(scalable framework for integrated deep learning chips)--Puzzle,它包含从处理任务输入到运行时管理芯片资源的完整流程,并自适应地生成高效的任务调度和资源分配方案,降低冗余访存和芯粒间通信开销.实验结果表明,该可扩展框架为深度学习集成芯片生成的任务部署方案可自适应于不同的工作负载和硬件资源配置,与现有方法相比平均降低27.5%的工作负载运行延迟.展开更多
OBJECTIVE:To determine the mechanisms by which Kangxianling(KXL) treats renal interstitial fibrosis using a customized gene chip.METHODS:Twelve out of 18 specific pathogen-free sprague dawley(SPF SD) rats underwent a ...OBJECTIVE:To determine the mechanisms by which Kangxianling(KXL) treats renal interstitial fibrosis using a customized gene chip.METHODS:Twelve out of 18 specific pathogen-free sprague dawley(SPF SD) rats underwent a unilateral ureteral occlusion.These rats were then randomly assigned into either the model unilateral ureteral obstruction(UUO) or Kangxianling(KXL) group.The other six rats were assigned to the sham-operated group.The UUO and sham-operated groups were given normal saline via intragastric administration,whereas the KXL group was given KXL via intragastric administration.All rats were sacrificed for renal tissue collection(i.e.left nephridial tissue),and the detection of genetic changes with the customized chip.RESULTS:Compared to the sham-operated group,transforming growth factor-β1(TGF-β1),Smad2,and Smad3 genes were significantly up-regulated in the UUO group,with >1.5-fold rise(P<0.01).The Smad7 gene was significantly reduced in the UUO versus sham-operated group,with a down-regulation of >1.5-fold(P<0.01).In the KXL group,TGF-β1,Smad2,and Smad3 genes were significantly reduced compared to the UUO group,with a down-regulation of >1.5-fold(P<0.01),whereas the Smad7 gene was significantly increased compared to the UUO group,with an up-regulation of >1.5-fold(P<0.01).CONCLUSION:It was found that KXL can significantly reduce the gene levels of TGF-β1,Smad2,and Smad3.Immunohistochemistry findings also revealed significantly lower TGF-β1/Smads-mediated gene transcription activity.These findings suggest that KXL may negatively regulate the TGF-β1/Smads signal pathway to inhibit the occurrence of renal fibrosis.展开更多
文摘芯粒集成逐渐成为不同场景下敏捷定制深度学习芯片的高可扩展性的解决方案,芯片设计者可以通过集成设计、验证完成的第三方芯粒来降低芯片开发周期和成本,提高芯片设计的灵活性和芯片良率.在传统的芯片设计和商业模式中,编译器等专用软件工具链是芯片解决方案的组成部分,并在芯片性能和开发中发挥重要作用.然而,当使用第三方芯粒进行芯片敏捷定制时,第三方芯粒所提供的专用工具链无法预知整个芯片的资源,因此无法解决敏捷定制的深度学习芯片的任务部署问题,而为敏捷定制的芯片设计全新的工具链需要大量的时间成本,失去了芯片敏捷定制的优势.因此,提出一种面向深度学习集成芯片的可扩展框架(scalable framework for integrated deep learning chips)--Puzzle,它包含从处理任务输入到运行时管理芯片资源的完整流程,并自适应地生成高效的任务调度和资源分配方案,降低冗余访存和芯粒间通信开销.实验结果表明,该可扩展框架为深度学习集成芯片生成的任务部署方案可自适应于不同的工作负载和硬件资源配置,与现有方法相比平均降低27.5%的工作负载运行延迟.
基金Supported by National Natural Science Foundation of China Grant(30873259)/(81173219)Ministry of Science and Technology in the pharmaceutical industry,scientific research and special(201007005)+7 种基金Shanghai Science and Technology Innovation Plan of Action(11DZ1973100)Shanghai Excellent academic leaders Project Grant(08XD14039)E-institute of TCM Internal Medicine of Shanghai Municipal Education Commission Grant(E03008)Innovative Research Team in Universities,Shanghai Municipal Education Commission of GrantWenzhou Science & Technology Bureau of Grant(Y20070049)Wenzhou Municipal Health Bureau of Grant(2010A012)Wenzhou Center of Traditional Chinese Medicine Laboratory GrantZhejiang Province 151 and Wenzhou Municipal 551 Talented Grant
文摘OBJECTIVE:To determine the mechanisms by which Kangxianling(KXL) treats renal interstitial fibrosis using a customized gene chip.METHODS:Twelve out of 18 specific pathogen-free sprague dawley(SPF SD) rats underwent a unilateral ureteral occlusion.These rats were then randomly assigned into either the model unilateral ureteral obstruction(UUO) or Kangxianling(KXL) group.The other six rats were assigned to the sham-operated group.The UUO and sham-operated groups were given normal saline via intragastric administration,whereas the KXL group was given KXL via intragastric administration.All rats were sacrificed for renal tissue collection(i.e.left nephridial tissue),and the detection of genetic changes with the customized chip.RESULTS:Compared to the sham-operated group,transforming growth factor-β1(TGF-β1),Smad2,and Smad3 genes were significantly up-regulated in the UUO group,with >1.5-fold rise(P<0.01).The Smad7 gene was significantly reduced in the UUO versus sham-operated group,with a down-regulation of >1.5-fold(P<0.01).In the KXL group,TGF-β1,Smad2,and Smad3 genes were significantly reduced compared to the UUO group,with a down-regulation of >1.5-fold(P<0.01),whereas the Smad7 gene was significantly increased compared to the UUO group,with an up-regulation of >1.5-fold(P<0.01).CONCLUSION:It was found that KXL can significantly reduce the gene levels of TGF-β1,Smad2,and Smad3.Immunohistochemistry findings also revealed significantly lower TGF-β1/Smads-mediated gene transcription activity.These findings suggest that KXL may negatively regulate the TGF-β1/Smads signal pathway to inhibit the occurrence of renal fibrosis.
