A series of α-bromoarylethanones were prepared in high yields by a practical and efficient method. The arylethanones were reacted with bromine to give a mixture of α- and α, α-dibromides, which were debrominated w...A series of α-bromoarylethanones were prepared in high yields by a practical and efficient method. The arylethanones were reacted with bromine to give a mixture of α- and α, α-dibromides, which were debrominated with diethylphosphite in the presence of triethylamine to give the desired α-monobromo products.展开更多
Photochemical processes of benzophenone （BP） and xanthone （XT） with tryptophan （TrpH） and tyrosine （TyrOH） were stud- ied using the laser flash photolysis technique. It has been observed that the triplet state...Photochemical processes of benzophenone （BP） and xanthone （XT） with tryptophan （TrpH） and tyrosine （TyrOH） were stud- ied using the laser flash photolysis technique. It has been observed that the triplet state of BP and XT reacted with TrpH and TyrOH by hydrogen transfer with the formation of BP and XT ketyl radicals and oxidized radicals of Trp＂ and TyrO＇. The re- lated rate constants of these reactions were determined in this paper. The free energy changes （AG） of these reactions suggested that the proposed hydrogen transfer mechanism was thermodynamically feasible. These results provide theoretical foundation for further studying structural effects on the photochemical behaviors of proteins with triplet state BP and XT.展开更多
文摘A series of α-bromoarylethanones were prepared in high yields by a practical and efficient method. The arylethanones were reacted with bromine to give a mixture of α- and α, α-dibromides, which were debrominated with diethylphosphite in the presence of triethylamine to give the desired α-monobromo products.
基金supported by the National Natural Science Foundation of China (21173252)
文摘Photochemical processes of benzophenone （BP） and xanthone （XT） with tryptophan （TrpH） and tyrosine （TyrOH） were stud- ied using the laser flash photolysis technique. It has been observed that the triplet state of BP and XT reacted with TrpH and TyrOH by hydrogen transfer with the formation of BP and XT ketyl radicals and oxidized radicals of Trp＂ and TyrO＇. The re- lated rate constants of these reactions were determined in this paper. The free energy changes （AG） of these reactions suggested that the proposed hydrogen transfer mechanism was thermodynamically feasible. These results provide theoretical foundation for further studying structural effects on the photochemical behaviors of proteins with triplet state BP and XT.
