Chlorothalonil 1 was treated with anhydrous KF in DMF at 110 ℃ to give the corresponding crystalline fluorine-containing 1,3-benzenedicarbonitrile 2. KF was used in an equivalent to the number of chlorine atoms to be...Chlorothalonil 1 was treated with anhydrous KF in DMF at 110 ℃ to give the corresponding crystalline fluorine-containing 1,3-benzenedicarbonitrile 2. KF was used in an equivalent to the number of chlorine atoms to be substituted. Compound 2 was subsequently reacted with ammonia to yield compound 3. In addition, halobenzamide 4 were refluxed with oxalyl chloride in anhydrous 1,2-dichloroethane(DCE) to yield benzoylisocyanates 5. Finally, seven novel BPUs chitin inhibitors 6a—6g were synthesized via the selective reaction of compound 3 with benzoylisocyanate derivatives 5, the total yield is over 30%—50%.展开更多
Six novel bis-benzoylphenylurea compounds have been synthesized from available compound chlorothalonil 1(2,4,5,6-tetrachloroisophthalonitrile) in yield of 30%～50%. The synthetic route has advantages of mild reaction ...Six novel bis-benzoylphenylurea compounds have been synthesized from available compound chlorothalonil 1(2,4,5,6-tetrachloroisophthalonitrile) in yield of 30%～50%. The synthetic route has advantages of mild reaction conditions and higher yields. All of the bis-benzoylphenylurea compounds were investigated by IR, 1H NMR, FAB-MS and HRMS. Preliminary insecticidal activities of the title compounds have been tested. The results showed the compounds had only weak activity against Mythimna Separata Walker and Culex Pipiens Pallens.展开更多
文摘Chlorothalonil 1 was treated with anhydrous KF in DMF at 110 ℃ to give the corresponding crystalline fluorine-containing 1,3-benzenedicarbonitrile 2. KF was used in an equivalent to the number of chlorine atoms to be substituted. Compound 2 was subsequently reacted with ammonia to yield compound 3. In addition, halobenzamide 4 were refluxed with oxalyl chloride in anhydrous 1,2-dichloroethane(DCE) to yield benzoylisocyanates 5. Finally, seven novel BPUs chitin inhibitors 6a—6g were synthesized via the selective reaction of compound 3 with benzoylisocyanate derivatives 5, the total yield is over 30%—50%.
文摘Six novel bis-benzoylphenylurea compounds have been synthesized from available compound chlorothalonil 1(2,4,5,6-tetrachloroisophthalonitrile) in yield of 30%～50%. The synthetic route has advantages of mild reaction conditions and higher yields. All of the bis-benzoylphenylurea compounds were investigated by IR, 1H NMR, FAB-MS and HRMS. Preliminary insecticidal activities of the title compounds have been tested. The results showed the compounds had only weak activity against Mythimna Separata Walker and Culex Pipiens Pallens.
