糖尿病的治疗有了新希望——研究者们在动物实验中证明一种欧洲传统的药物能够同时阻断三条主要的生化通路,这三条通路可以引起血管破损从而导致严重的糖尿病并发症。 阿尔伯特·爱因斯坦医学院(Albert Einstein College of Medici...糖尿病的治疗有了新希望——研究者们在动物实验中证明一种欧洲传统的药物能够同时阻断三条主要的生化通路,这三条通路可以引起血管破损从而导致严重的糖尿病并发症。 阿尔伯特·爱因斯坦医学院(Albert Einstein College of Medicine)的Michael Brownlee博士是进行此项研究的高级研究员。他们的研究成果发表在最近的Nature Medicine上。展开更多
The molecular structure of N, N-bis ( 2-chloroethyl )-N'-isopropyl-N'-phenyl thioureido phosphoramide has been determined by X-ray diffraction method. The crystal(C_14H_23Cl_4N_4OPS) is monoclinic with space g...The molecular structure of N, N-bis ( 2-chloroethyl )-N'-isopropyl-N'-phenyl thioureido phosphoramide has been determined by X-ray diffraction method. The crystal(C_14H_23Cl_4N_4OPS) is monoclinic with space group P21/n,α=13. 398(2) , b= 10. 351(4), c= 14. 595(3) A, β= 101. 45(1)°, V=1983(2) A3 Mr=397. 31, Z=4, Dx=1. 34 g/cm3 , μ= 5. 17 cm-1, F(000) = 832 , R=0. 056 and Rω=0. 060 for 1856 reflections with I≥3σ(Ⅰ).The chemical shifts of the hydrogen atoms bonded to nitrogen atoms N (4) and N (33 are 10. 96 ppm and 7. 57 ppm respectively locating in the lower field. This abnormal situation can be explained by the formation of intramolecular and intermolecular hydrogen bonds. And the X-ray crystallographic analysis demonstrates the existence of the H-bonding six-membered ring in the structure.展开更多
文摘糖尿病的治疗有了新希望——研究者们在动物实验中证明一种欧洲传统的药物能够同时阻断三条主要的生化通路,这三条通路可以引起血管破损从而导致严重的糖尿病并发症。 阿尔伯特·爱因斯坦医学院(Albert Einstein College of Medicine)的Michael Brownlee博士是进行此项研究的高级研究员。他们的研究成果发表在最近的Nature Medicine上。
文摘The molecular structure of N, N-bis ( 2-chloroethyl )-N'-isopropyl-N'-phenyl thioureido phosphoramide has been determined by X-ray diffraction method. The crystal(C_14H_23Cl_4N_4OPS) is monoclinic with space group P21/n,α=13. 398(2) , b= 10. 351(4), c= 14. 595(3) A, β= 101. 45(1)°, V=1983(2) A3 Mr=397. 31, Z=4, Dx=1. 34 g/cm3 , μ= 5. 17 cm-1, F(000) = 832 , R=0. 056 and Rω=0. 060 for 1856 reflections with I≥3σ(Ⅰ).The chemical shifts of the hydrogen atoms bonded to nitrogen atoms N (4) and N (33 are 10. 96 ppm and 7. 57 ppm respectively locating in the lower field. This abnormal situation can be explained by the formation of intramolecular and intermolecular hydrogen bonds. And the X-ray crystallographic analysis demonstrates the existence of the H-bonding six-membered ring in the structure.
