Chronic heart failure and depressive disorders have a high prevalence and incidence in the elderly. Several studies have shown how depression tends to exacerbate coexisting chronic heart failure and its clinical outco...Chronic heart failure and depressive disorders have a high prevalence and incidence in the elderly. Several studies have shown how depression tends to exacerbate coexisting chronic heart failure and its clinical outcomes and vice versa, especially in the elderly. The negative synergism between chronic heart failure and depression in the elderly may be approached only taking into account the multifaceted pathophysiological characteristics underlying both these conditions, such as behavioural factors, neurohormonal activation, inflammatory mediators, hypercoagulability and vascular damage. Nevertheless, the pathophysiological link between these two conditions is not well established yet. Despite the high prevalence of depression in chronic heart failure elderly patients and its negative prognostic value, it is often unrecognized especially because of shared symptoms. So the screening of mood disorders, using reliable questionnaires, is recommended in elderly patients with chronic heart failure, even if cannot substitute a diagnostic interview by mental health professionals. In this setting, treatment of depression requires a multidisciplinary approach including： psychotherapy, antidepressants, exercise training and electroconvulsive therapy. Pharmacological therapy with selective serotonin reuptake inhibitors, despite conflicting results, improves quality of life but does not guarantee better outcomes. Exercise training is effective in improving quality of life and prognosis but at the same time cardiac rehabilitation services are vastly underutilized.展开更多
目的为了拓展和组织策划中国高质量稿源,提高国内药学期刊的学术影响力,对高影响力药理学和药学期刊上的中国论文进行分析。方法采用期刊引证报告(JCR)多指标等综合因素选出高影响力药学期刊11种,利用Web of Sciences平台核心合集数据...目的为了拓展和组织策划中国高质量稿源,提高国内药学期刊的学术影响力,对高影响力药理学和药学期刊上的中国论文进行分析。方法采用期刊引证报告(JCR)多指标等综合因素选出高影响力药学期刊11种,利用Web of Sciences平台核心合集数据库检索2007年1月~2017年12月中国作者发表在这11种期刊上的论文,分析论文数量及其高被引论文的数量、来源机构及其内容特征。结果十年间中国作者在11种期刊上共发表论文7416篇,其中药理学和药剂学论文数量较多;论文均来自中国从事药学研究的重点大学和研究机构,包括香港大学;在高被引论文中,中国论文数量为105篇,其中药剂学类期刊上66篇、药物发现类期刊上6篇、药理学类期刊上33篇;这些高被引论文同样来自我国从事药学研究的重点大学和研究机构,还有香港大学、苏州大学;高被引论文的共同内容特点是针对肿瘤、心脑血管以及神经系统研究药物的给药途径、作用靶点及作用机制研究。结论中国作者在高影响力药理学和药剂学期刊上的发文数量较多,占主要地位,在国际药学领域扮演着越来越重要的角色,尤其药剂学科的学者紧跟学术前沿,引领学科发展;重点大学及科研机构仍是从事药学研究工作的重点单位,目前我国药学的研究热点集中在肿瘤、心脑血管以及神经系统方面。因此,国内药学期刊拓宽组织策划高质量稿件应重点关注以上领先的研究领域和活跃的重点大学、科研机构,从而确定约稿的主题,同时还应重点关注具有中国特色的学术领域,如中国传统医药。展开更多
文摘Chronic heart failure and depressive disorders have a high prevalence and incidence in the elderly. Several studies have shown how depression tends to exacerbate coexisting chronic heart failure and its clinical outcomes and vice versa, especially in the elderly. The negative synergism between chronic heart failure and depression in the elderly may be approached only taking into account the multifaceted pathophysiological characteristics underlying both these conditions, such as behavioural factors, neurohormonal activation, inflammatory mediators, hypercoagulability and vascular damage. Nevertheless, the pathophysiological link between these two conditions is not well established yet. Despite the high prevalence of depression in chronic heart failure elderly patients and its negative prognostic value, it is often unrecognized especially because of shared symptoms. So the screening of mood disorders, using reliable questionnaires, is recommended in elderly patients with chronic heart failure, even if cannot substitute a diagnostic interview by mental health professionals. In this setting, treatment of depression requires a multidisciplinary approach including： psychotherapy, antidepressants, exercise training and electroconvulsive therapy. Pharmacological therapy with selective serotonin reuptake inhibitors, despite conflicting results, improves quality of life but does not guarantee better outcomes. Exercise training is effective in improving quality of life and prognosis but at the same time cardiac rehabilitation services are vastly underutilized.
文摘目的为了拓展和组织策划中国高质量稿源,提高国内药学期刊的学术影响力,对高影响力药理学和药学期刊上的中国论文进行分析。方法采用期刊引证报告(JCR)多指标等综合因素选出高影响力药学期刊11种,利用Web of Sciences平台核心合集数据库检索2007年1月~2017年12月中国作者发表在这11种期刊上的论文,分析论文数量及其高被引论文的数量、来源机构及其内容特征。结果十年间中国作者在11种期刊上共发表论文7416篇,其中药理学和药剂学论文数量较多;论文均来自中国从事药学研究的重点大学和研究机构,包括香港大学;在高被引论文中,中国论文数量为105篇,其中药剂学类期刊上66篇、药物发现类期刊上6篇、药理学类期刊上33篇;这些高被引论文同样来自我国从事药学研究的重点大学和研究机构,还有香港大学、苏州大学;高被引论文的共同内容特点是针对肿瘤、心脑血管以及神经系统研究药物的给药途径、作用靶点及作用机制研究。结论中国作者在高影响力药理学和药剂学期刊上的发文数量较多,占主要地位,在国际药学领域扮演着越来越重要的角色,尤其药剂学科的学者紧跟学术前沿,引领学科发展;重点大学及科研机构仍是从事药学研究工作的重点单位,目前我国药学的研究热点集中在肿瘤、心脑血管以及神经系统方面。因此,国内药学期刊拓宽组织策划高质量稿件应重点关注以上领先的研究领域和活跃的重点大学、科研机构,从而确定约稿的主题,同时还应重点关注具有中国特色的学术领域,如中国传统医药。
