As the novel coronavirus disease 2019(COVID-19)and its variants continue to rage into the second year of a global pandemic,many success stories of applying Chinese herbal medicine(CHM)to treat COVID-19 patients contin...As the novel coronavirus disease 2019(COVID-19)and its variants continue to rage into the second year of a global pandemic,many success stories of applying Chinese herbal medicine(CHM)to treat COVID-19 patients continue to emerge from China and other part of the world.Herewith,from a systems medicine perspective,the authors analyze those experiences and categorize them into four major treatment principles:(1)focusing on eliminating toxins in the early stage of the disease,(2)tonifying deficiency of the body throughout the entire disease course,(3)treating the affected lung and intestine simultaneously based on visceral interactions,(4)cooling blood and removing blood stasis at the later stage,as well as interpret the rationale of these principles.This is helpful not only in reducing the complexity of promoting the CHM applications to enhance anti-COVID-19 efficacy,but also in ramping out the process of integrating traditional Chinese medicine with modern medical practices.展开更多
OBJECTIVE: To evaluate the potential beneficial effects of Inonotus obliquuspolysaccharides(IOP) on the alleviation of physical fatigue in mice.METHODS: Sixty-four male mice were randomly divided into four groups(n = ...OBJECTIVE: To evaluate the potential beneficial effects of Inonotus obliquuspolysaccharides(IOP) on the alleviation of physical fatigue in mice.METHODS: Sixty-four male mice were randomly divided into four groups(n = 16 per group). Mice were orally administered IOP for a period of 14 days at 0,100,200 and 300 mg/kg/d,and were assigned to the control,IOP-100,IOP-200,and IOP-300 groups,respectively by the random number table method. Mice in the control group received an oral administration of sterile distilled water. A forced swimming test was performed for 8 mice per group at one hour after the last treatment. The other 8mice in each group swam for 30 min. Blood,liver and muscle samples were taken after resting for30 min. Levels of blood urea nitrogen and lactate,as well as glycogen contents of the liver and muscle were measured. Morphology of liver was observed by light microscopy.RESULTS: IOP extended the swimming time of mice,and increased the glycogen content of liver and muscle,but decreased blood lactic acid and serum urea nitrogen levels. IOP had no toxic effects on major organs such as the liver as assessed by histopathological examinations.CONCLUSION: IOP might be a potential anti-fatigue pharmacological agent.展开更多
文摘As the novel coronavirus disease 2019(COVID-19)and its variants continue to rage into the second year of a global pandemic,many success stories of applying Chinese herbal medicine(CHM)to treat COVID-19 patients continue to emerge from China and other part of the world.Herewith,from a systems medicine perspective,the authors analyze those experiences and categorize them into four major treatment principles:(1)focusing on eliminating toxins in the early stage of the disease,(2)tonifying deficiency of the body throughout the entire disease course,(3)treating the affected lung and intestine simultaneously based on visceral interactions,(4)cooling blood and removing blood stasis at the later stage,as well as interpret the rationale of these principles.This is helpful not only in reducing the complexity of promoting the CHM applications to enhance anti-COVID-19 efficacy,but also in ramping out the process of integrating traditional Chinese medicine with modern medical practices.
基金Supported by Science and Technology Research program of Jilin Province,Education Department in the 12th Five Year Plan(China)(Research on Prevention of Inonotus Obliquus Polysaccharides for High Power Microwave Radiation Induced Injury in Rats,No.2012495)
文摘OBJECTIVE: To evaluate the potential beneficial effects of Inonotus obliquuspolysaccharides(IOP) on the alleviation of physical fatigue in mice.METHODS: Sixty-four male mice were randomly divided into four groups(n = 16 per group). Mice were orally administered IOP for a period of 14 days at 0,100,200 and 300 mg/kg/d,and were assigned to the control,IOP-100,IOP-200,and IOP-300 groups,respectively by the random number table method. Mice in the control group received an oral administration of sterile distilled water. A forced swimming test was performed for 8 mice per group at one hour after the last treatment. The other 8mice in each group swam for 30 min. Blood,liver and muscle samples were taken after resting for30 min. Levels of blood urea nitrogen and lactate,as well as glycogen contents of the liver and muscle were measured. Morphology of liver was observed by light microscopy.RESULTS: IOP extended the swimming time of mice,and increased the glycogen content of liver and muscle,but decreased blood lactic acid and serum urea nitrogen levels. IOP had no toxic effects on major organs such as the liver as assessed by histopathological examinations.CONCLUSION: IOP might be a potential anti-fatigue pharmacological agent.
