Synthesis,characterization of Co_3O_4 and Ag-Co_3O_4 composites and evaluation of their photo-catalytic activities towards photo-degradation of aqueous solution of rhodamine B dye under irradiation of visible light ha...Synthesis,characterization of Co_3O_4 and Ag-Co_3O_4 composites and evaluation of their photo-catalytic activities towards photo-degradation of aqueous solution of rhodamine B dye under irradiation of visible light have been described in this paper.Co_3O_4 was prepared by solid phase mechano chemical process using Co(NO_3)_2·6H_2O and NH_4 HCO_3 as precursor materials.Ag was deposited on Co_3O_4 from AgNO_3 using Calotropis gigantea extract as reducing agent.XRD,SEM and FTIR were used for characterization of prepared composites.Photo-catalytic efficiencies of as-prepared Co_3O_4 and Ag-Co_3O_4 were evaluated for aqueous phase photo-degradation of rhodamine B.It was found that deposition of Ag on Co_3O_4 highly enhanced the photo-catalytic activity of Co_3O_4.Photo-catalytic degradation followed the Eley–Rideal mechanism.About 100% and 91% photo-degradation of 40 ml dye solution achieved at 313 K in 90 and 120 min over 0.05 g of Ag-Co_3O_4 as photo-catalyst using 100 and 200 mg·L^(-1) as initial concentration of dye respectively.展开更多
The similarities of the non-linear chemical （NLC） fingerprints of Radix Glycyrrhizaes from four producing areas and eight other traditional Chinese medicines （TCMs） were calculated, using a systemic similarity cal...The similarities of the non-linear chemical （NLC） fingerprints of Radix Glycyrrhizaes from four producing areas and eight other traditional Chinese medicines （TCMs） were calculated, using a systemic similarity calculation method proposed and three other main calculation ones （Euclidean distance, correlation coefficient and included angle cosine）. All of the correlation coefficient similarities of different TCMs are higher than 0.952, and the included angle cosines are all higher than 0.962. So, both the conelation coefficient and included angle cosine similarities are unable to be used as the criteria for quantitatively evaluating the similarities of NLC fingerprints of TCMs. Although all of the Euclidean distance similarities of Berry Liquorices from four producing areas are less than 73, those of the other eight TCMs are all more than 180. The Euclidean distance cannot reflect the relative magnitudes of the feature differences in the NLC fingerprints very correctly. The systemic similarity method is the best among the four ones. All of the systemic similarities of Berry Liquorices from the four producing areas are higher than 0.962, while those of the other eight TCMs are all lower than 0.805, and the systemic similarity can reflect the differences between samples most faithfully, and can be used as a quantitative one evaluating the similarities of NLC fingerprints of TCMs, by which TCM could be distinguished and evaluated quickly, simply and exactly.展开更多
目的:探讨急性泛发性发疹性脓疱病(acute generalized exanthematous pustulosis,AGEP)的病因、临床特征及处理对策,为临床医师安全用药和药师药学服务提供参考。方法:采用Euro SCAR (the european study of severe cutaneous adverse r...目的:探讨急性泛发性发疹性脓疱病(acute generalized exanthematous pustulosis,AGEP)的病因、临床特征及处理对策,为临床医师安全用药和药师药学服务提供参考。方法:采用Euro SCAR (the european study of severe cutaneous adverse reactions)评分表和药物不良反应因果评价法对2011年7月-2018年7月某三级皮肤病医院收治的25例AGEP病例进行分析。结果:25例患者均由药物引起,可疑致敏药物以抗菌药物为主(16例,64%),其次为非甾体类抗炎药(3例,12%),中药及中成药(2例,8%),苯二氮■类镇静催眠药地西泮(1例,4%),抗疟药羟氯喹(1例,4%),多巴胺第2受体拮抗剂甲氧氯普胺(1例,4%)及选择性5-羟色胺_4受体激动药莫沙必利(1例,4%)。25例患者经治疗均好转出院。结论:药物,尤其是抗菌药物是诱发AGEP的主要原因,临床使用中应加强药学监护,发现异常应及时停药并给予对症处理,控制并发症的发生。展开更多
OBJECTIVE: Sui Zheng Shi Liang strategy (regulating prescription dosage with different syndromes) is an important part of syndrome differentiation and treatment in Traditional Chinese Medicine (TCM). Questionnaires we...OBJECTIVE: Sui Zheng Shi Liang strategy (regulating prescription dosage with different syndromes) is an important part of syndrome differentiation and treatment in Traditional Chinese Medicine (TCM). Questionnaires were given to doctors and patients to study the essential factors (indicators and timing) of Sui Zheng Shi Liang strategy in the treatment process of type 2 diabetes (T2DM). METHODS: Two questionnaires were designed for diabetes patients and their doctors. The questionnaires included the most important indicators for determining the patient's condition, the ability of TCM in treating T2DM, the length of time it takes for TCM to be effective, and when to adjust the prescription dosage.The frequency of answers was calculated, summarized, and analyzed after the survey. RESULTS: Twenty questionnaires from doctors and 90 questionnaires from patients were included in the analysis. Doctors and patients recognized thatTCM could decrease blood glucose, improve syndromes, and delay complications. Doctors were mainly concerned about glycosylated hemoglobin, while the patients were concerned about fasting plasma glucose for determining whether treatment was effective. Doctors also paid attention to changes in blood sugar and syndromes 2 weeks after medication was given as the indication to adjust the prescription dosage, while patients were concerned about these factors in 4 weeks.The prescription should be regulated when there are side effects or the medication is ineffective. CONCLUSION: The essential factor in the treatment process of T2DM in Sui Zheng Shi Liang strategy is that if fasting blood glucose level did not decrease after 4 weeks of treatment, the Chinese medicine prescription should be adjusted.展开更多
Toxicological pathology plays a key role in drug safety assessment. To enhance the research level of toxicological pathology, the following stud-ies should be carried out urgently: setting up a standard operation proc...Toxicological pathology plays a key role in drug safety assessment. To enhance the research level of toxicological pathology, the following stud-ies should be carried out urgently: setting up a standard operation procedure (SOP) for toxico-logical pathology assessment; emphasizing on immunotoxicology evaluation; adopting a new ex-periment model of replacement, featuring high speed and reliability; introducing new techniques and new models in toxicological mechanism re-search; and establishing a new appraisal system to screen innovative drug and rapid and high pre-cision methods for early security assessment, de-tection and measurement.展开更多
基金The World Academy of Sciences(TWAS)(13-301 RG/MSN/AS_C) is acknowledged for financial support under COMSTECH-TWAS Grants Program
文摘Synthesis,characterization of Co_3O_4 and Ag-Co_3O_4 composites and evaluation of their photo-catalytic activities towards photo-degradation of aqueous solution of rhodamine B dye under irradiation of visible light have been described in this paper.Co_3O_4 was prepared by solid phase mechano chemical process using Co(NO_3)_2·6H_2O and NH_4 HCO_3 as precursor materials.Ag was deposited on Co_3O_4 from AgNO_3 using Calotropis gigantea extract as reducing agent.XRD,SEM and FTIR were used for characterization of prepared composites.Photo-catalytic efficiencies of as-prepared Co_3O_4 and Ag-Co_3O_4 were evaluated for aqueous phase photo-degradation of rhodamine B.It was found that deposition of Ag on Co_3O_4 highly enhanced the photo-catalytic activity of Co_3O_4.Photo-catalytic degradation followed the Eley–Rideal mechanism.About 100% and 91% photo-degradation of 40 ml dye solution achieved at 313 K in 90 and 120 min over 0.05 g of Ag-Co_3O_4 as photo-catalyst using 100 and 200 mg·L^(-1) as initial concentration of dye respectively.
基金Project(2009GJD20033) supported by the National Science and Technology Ministry of China
文摘The similarities of the non-linear chemical （NLC） fingerprints of Radix Glycyrrhizaes from four producing areas and eight other traditional Chinese medicines （TCMs） were calculated, using a systemic similarity calculation method proposed and three other main calculation ones （Euclidean distance, correlation coefficient and included angle cosine）. All of the correlation coefficient similarities of different TCMs are higher than 0.952, and the included angle cosines are all higher than 0.962. So, both the conelation coefficient and included angle cosine similarities are unable to be used as the criteria for quantitatively evaluating the similarities of NLC fingerprints of TCMs. Although all of the Euclidean distance similarities of Berry Liquorices from four producing areas are less than 73, those of the other eight TCMs are all more than 180. The Euclidean distance cannot reflect the relative magnitudes of the feature differences in the NLC fingerprints very correctly. The systemic similarity method is the best among the four ones. All of the systemic similarities of Berry Liquorices from the four producing areas are higher than 0.962, while those of the other eight TCMs are all lower than 0.805, and the systemic similarity can reflect the differences between samples most faithfully, and can be used as a quantitative one evaluating the similarities of NLC fingerprints of TCMs, by which TCM could be distinguished and evaluated quickly, simply and exactly.
文摘目的:探讨急性泛发性发疹性脓疱病(acute generalized exanthematous pustulosis,AGEP)的病因、临床特征及处理对策,为临床医师安全用药和药师药学服务提供参考。方法:采用Euro SCAR (the european study of severe cutaneous adverse reactions)评分表和药物不良反应因果评价法对2011年7月-2018年7月某三级皮肤病医院收治的25例AGEP病例进行分析。结果:25例患者均由药物引起,可疑致敏药物以抗菌药物为主(16例,64%),其次为非甾体类抗炎药(3例,12%),中药及中成药(2例,8%),苯二氮■类镇静催眠药地西泮(1例,4%),抗疟药羟氯喹(1例,4%),多巴胺第2受体拮抗剂甲氧氯普胺(1例,4%)及选择性5-羟色胺_4受体激动药莫沙必利(1例,4%)。25例患者经治疗均好转出院。结论:药物,尤其是抗菌药物是诱发AGEP的主要原因,临床使用中应加强药学监护,发现异常应及时停药并给予对症处理,控制并发症的发生。
基金Supported by the National Basic Research Program (973Program, No. 2010CB530601)the National Natural Science Fund (No. 81274000)
文摘OBJECTIVE: Sui Zheng Shi Liang strategy (regulating prescription dosage with different syndromes) is an important part of syndrome differentiation and treatment in Traditional Chinese Medicine (TCM). Questionnaires were given to doctors and patients to study the essential factors (indicators and timing) of Sui Zheng Shi Liang strategy in the treatment process of type 2 diabetes (T2DM). METHODS: Two questionnaires were designed for diabetes patients and their doctors. The questionnaires included the most important indicators for determining the patient's condition, the ability of TCM in treating T2DM, the length of time it takes for TCM to be effective, and when to adjust the prescription dosage.The frequency of answers was calculated, summarized, and analyzed after the survey. RESULTS: Twenty questionnaires from doctors and 90 questionnaires from patients were included in the analysis. Doctors and patients recognized thatTCM could decrease blood glucose, improve syndromes, and delay complications. Doctors were mainly concerned about glycosylated hemoglobin, while the patients were concerned about fasting plasma glucose for determining whether treatment was effective. Doctors also paid attention to changes in blood sugar and syndromes 2 weeks after medication was given as the indication to adjust the prescription dosage, while patients were concerned about these factors in 4 weeks.The prescription should be regulated when there are side effects or the medication is ineffective. CONCLUSION: The essential factor in the treatment process of T2DM in Sui Zheng Shi Liang strategy is that if fasting blood glucose level did not decrease after 4 weeks of treatment, the Chinese medicine prescription should be adjusted.
文摘Toxicological pathology plays a key role in drug safety assessment. To enhance the research level of toxicological pathology, the following stud-ies should be carried out urgently: setting up a standard operation procedure (SOP) for toxico-logical pathology assessment; emphasizing on immunotoxicology evaluation; adopting a new ex-periment model of replacement, featuring high speed and reliability; introducing new techniques and new models in toxicological mechanism re-search; and establishing a new appraisal system to screen innovative drug and rapid and high pre-cision methods for early security assessment, de-tection and measurement.
