The relative characteristics of motion of the fuel and shell upon launching is analyzed. By means of mechanical analysis and calculation, it is proposed that relative motion exists not only in the ranges between the f...The relative characteristics of motion of the fuel and shell upon launching is analyzed. By means of mechanical analysis and calculation, it is proposed that relative motion exists not only in the ranges between the fuel and shell of the warhead, but also in the fuel in different positions. The result of study indicates that the position of the fuel in the warhead has a marked influence on the relative motion, while the frictional coefficient between the fuel and shell has less influence upon it.展开更多
Chemotherapy-induced multi-drug resistance(MDR) in tumors poses a huge challenge for clinical treatment of tumors. The downregulation of the multi-drug resistance relative protein, represented by P-glycoprotein(P-gp),...Chemotherapy-induced multi-drug resistance(MDR) in tumors poses a huge challenge for clinical treatment of tumors. The downregulation of the multi-drug resistance relative protein, represented by P-glycoprotein(P-gp), can reverse MDR of cancer cells. In this study, we developed doxorubicin-loading nanocarrier based on the assembly of protein and antisense oligonucleotide(ASO) to combat MDR of cancer cells. The data demonstrate that the nanocarrier can efficiently deliver ASO to cytoplasm and downregulate the P-glycoprotein expression, subsequently improving the therapeutic effects of Dox in doxorubicin-resistant MCF-7/ADR cancer cells. The preparation is simple and effective, providing a powerful tool for gene delivery. Therefore, our nanocarrier shows high promise in cancer treatment.展开更多
文摘The relative characteristics of motion of the fuel and shell upon launching is analyzed. By means of mechanical analysis and calculation, it is proposed that relative motion exists not only in the ranges between the fuel and shell of the warhead, but also in the fuel in different positions. The result of study indicates that the position of the fuel in the warhead has a marked influence on the relative motion, while the frictional coefficient between the fuel and shell has less influence upon it.
基金supported by the National Natural Science Foundation of China (21325520, 21327009, 21405041, J1210040)the Foundation for Innovative Research Groups of National Natural Science Foundation of China (21521063)the Science and Technology Project of Hunan Province (2016RS2009, 2016WK2002)
文摘Chemotherapy-induced multi-drug resistance(MDR) in tumors poses a huge challenge for clinical treatment of tumors. The downregulation of the multi-drug resistance relative protein, represented by P-glycoprotein(P-gp), can reverse MDR of cancer cells. In this study, we developed doxorubicin-loading nanocarrier based on the assembly of protein and antisense oligonucleotide(ASO) to combat MDR of cancer cells. The data demonstrate that the nanocarrier can efficiently deliver ASO to cytoplasm and downregulate the P-glycoprotein expression, subsequently improving the therapeutic effects of Dox in doxorubicin-resistant MCF-7/ADR cancer cells. The preparation is simple and effective, providing a powerful tool for gene delivery. Therefore, our nanocarrier shows high promise in cancer treatment.
