耐多药肺结核继发肺部真菌感染51例临床分析

目的探讨耐多药肺结核继发肺部真菌感染的危险因素、临床特点及诊治方法,以提高对2病并存时临床表现的认识和综合处理的能力。方法回顾湖北黄石市二医院2002年以来收治的51例耐多药肺结核合并肺部真菌感染的病历资料,并进行分析。结果合并肺部真菌感染的耐多药肺结核均有明显易感因素,其临床特点:结核病史长;复治病例多;年龄偏大;肺部病变广泛,空洞多,病情较重;主要致病真菌为念珠菌。结论耐多药肺结核易继发肺部真菌感染,提高对2病并存的认识,有利于耐多药肺结核病的控制及降低死亡率。

Impact of medical therapies on inflammatory bowel disease complication rate

Crohn's disease and ulcerative colitis are progressive diseases associated with a high risk of complications over time including strictures,fistulae,perianal complications,surgery,and colorectal cancer.Changing the natural history and avoiding evolution to a disabling disease should be the main goal of treatment.In recent studies,mucosal healing has been associated with longer-term remission and fewer complications.Conventional therapies with immunosuppressive drugs are able to induce mucosal healing in a minority of cases but their impact on disease progression appears modest.Higher rates of mucosal healing can be achieved with anti-tumor necrosis factor therapies that reduce the risk of relapse,surgery and hospitalization,and are associated with perianal fistulae closure.These drugs might be able to change the natural history of the disease mainly when introduced early in the course of the disease.Treatment strategy in inflammatory bowel diseases should thus be tailored according to the risk that each patient could develop disabling disease.