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三维打印成形技术制备药物梯度控释给药系统研究 被引量:10
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作者 余灯广 刘洁 +2 位作者 杨勇 杨祥良 徐辉碧 《中国药学杂志》 CAS CSCD 北大核心 2006年第14期1080-1083,共4页
目的研究利用三维打印成形技术制备具有药物梯度特征的控释给药系统。方法以双氯芬酸钠为模型药物,利用三维打印技术制备其浓度梯度控释给药系统,通过常规分析、结构分析、体外释药试验检验所制备给药系统的基本性能、结构特征和释药特... 目的研究利用三维打印成形技术制备具有药物梯度特征的控释给药系统。方法以双氯芬酸钠为模型药物,利用三维打印技术制备其浓度梯度控释给药系统,通过常规分析、结构分析、体外释药试验检验所制备给药系统的基本性能、结构特征和释药特征。结果所制备给药系统的各项指标符合相关片剂标准,轴向能够阻止药物释放,径向药物呈梯度分布,98.14%的药物能按零级释放。结论应用三维打印成形技术可以制备具有特殊的结构组成和表面特性的给药系统,从而获得所需释药特征。 展开更多
关键词 三维打印 给药系统 药物梯度分布 零级控释
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Distribution Patterns of Medicinal Plants along an Elevational Gradient in Central Himalaya,Nepal 被引量:1
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作者 Maan B.ROKAYA Zuzana MÜNZBERGOVÁ +1 位作者 Mani R.SHRESTHA Binu TIMSINA 《Journal of Mountain Science》 SCIE CSCD 2012年第2期201-213,共13页
This study aimed to compare the distribution patterns and trends of plant parts used among different groups of medicinal plants, geographical regions,and between medicinal plants and all vascular plants.We used the pu... This study aimed to compare the distribution patterns and trends of plant parts used among different groups of medicinal plants, geographical regions,and between medicinal plants and all vascular plants.We used the published sources for elevation records of 2,331 medicinal plant species to interpolate presence between minimum and maximum elevations and estimated medicinal plant richness for each 100-m elevational band. Monte Carlo simulations were used to test whether differences in elevational distribution between different groups of medicinal plants were significant. Total number of medicinal plants as well as different groups showed unimodal relationship with elevation. The elevational distributions of medicinal plants significantly differ between regions and between medicinal plant groups.When comparing the richness of all medicinal plants to all vascular plants,Monte Carlo simulations indicated that the numbers of medicinal plants are higher than expected at low elevations.The highest richness of medicinal plants at low elevation could be possibly due to favorable environmental factors such as high temperature, rainfall,sunlight or due to higher density of human population and thus higher pressure on use of any plants in lower elevations. 展开更多
关键词 Species richness Rapoport's elevational rule Mid-domain effect Randomization test Unimodal pattern HIMALAYA Nepal
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