应用药物铺灸疗法辨证治疗痛风病78例临床观察

目的:研究应用药物辅灸疗法辨证治疗痛风病的临床疗效。方法:选取2015年1月至2016年12月期间秦皇岛市中医医院收治的痛风患者78例作为研究对象,根据随机数表法分为对照组、观察组,各39例。对照组患者采用秋水仙碱等对症治疗,观察组患者采用药物辅灸疗法辨证治疗,持续治疗2周,后给予患者1~3个月随访。比较2组患者治疗前后疼痛程度变化及治疗后血肌酐(Cre)、血尿素氮(BUN)、尿酸(UA)水平、生命质量。结果:治疗后,2组患者疼痛VAS评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组患者的Cre、BUN、UA水平均低于对照组,差异有统计学意义(P<0.05);观察组患者社会功能、生理功能、健康自我认识、心理功能评分均高于对照组,差异有统计学意义(P<0.05)。结论:应用药物辅灸疗法辨证治疗痛风病效果显著,能有效减轻患者疼痛程度,调节血清Cre、BUN、UA水平,缓解临床症状与体征,改善患者生命质量。

Histone modification as a drug resistance driver in brain tumors

Patients with brain tumors,specifically,malignant forms such as glioblastoma,medulloblastoma and ependymoma,exhibit dismal survival rates despite advances in treatment strategies.Chemotherapeutics,the primary adjuvant treatment for human brain tumors following surgery,commonly lack efficacy due to either intrinsic or acquired drug resistance.New treatments targeting epigenetic factors are being explored.Post-translational histone modification provides a critical regulatory platform for processes such as chromosome condensation and segregation,apoptosis,gene transcription,and DNA replication and repair.This work reviews how aberrant histone modifications and alterations in histone-modifying enzymes can drive the acquisition of drug resistance in brain tumors.Elucidating these mechanisms should lead to new treatments for overcoming drug resistance.

Heavy Metals in Dust Deposition in the Vicinity of Coal Ash Disposal Site Divkovici Ⅱ

DD （Dust deposition） was monitored over a 6-month period （April to September, 2011） at four sites located in villages near CADDⅡ（coal ash disposal site Divkovici Ⅱ）, one inside recultivated CADDⅠ （coal ash disposal site Divkovici Ⅰ） and at one in the middle of forest barrier as control site. The main aim of this paper is to perform monitoring of air dust pollution in the area by measuring of dust deposition, different metals associated with it, and probable adverse effects on human health. Concentrations of metals were measured by using Perkin-Elmer model Inductively Coupled Plasma and statistically evaluated with SPSS 17.0 statistical program. There was a correlation between some metals （Mn, Mo and Pb） and DD distribution. The daily limit values for concentration of DD proposed by national ＂Regulations on air quality＂ （200 mg/m^2d average annual value and 350 mg/m^2d high value） exceed at three measuring sites. The average maximum content of DD was 684.8 mg/m^2d downwind of CADDII, and the average minimum was 46.8 mg/m^2d at measuring site F. Concentrations of pollutants hazardous to the environment as Ni, Cr, Cu, Mo, Mn and Pb vary from one site to another.

Computational Screening of Novel Mitogen-activated Protein Kinase Kinase-1 （MEK1） Inhibitors by Docking and Scoring

The mitogen-activated protein kinase （MAPK） cell signal transduction pathways play a key role in determining the survival of cells. If these pathways can be controlled, they will prohibit the proliferation of cancer cells. To attain this goal, the authors utilize many drugs to interact with mitogen-activated protein kinase kinase-1 （MEK1） in MAPK, and use computer aided drug design （CADD） to analyze the ligand activities of proteins in MEKL The results show that in these drugs, the aromatic group in the terminal of the protein and the PHE209 will induce the stacking force, which is highly related to the actual activities of these drugs.

Structure-based design of hexahydropyrimidin-5-ols as novel non-peptidic β-secretase inhibitors

Based upon the crystal structure of a previously reported fragment hit that binds to Corresponding author. β-secretase, a novel series of non-peptidic small-molecule β-secretase inhibitors, namely hexahydropyrimidin-5-ols, along with two series of their analogues, were rationally designed through structural modification. The CADD study was performed and revealed good expectation. Inhibitory activities of the corresponding structural cores were tested, which provided further support for our design approach.

Design and synthesis of benzimidamides as potential BACE1 inhibitors

Computer aided fragment-based lead discovery has been successfully applied to the design of inhibitors of aspartyl protease enzyme β-secretase（BACE1）.A benzimidamide fragment,which binds to the two catalytic aspartic acid residues in the active site of the enzyme,was selected as the starting compound.A novel series of 3-phenethylbenzimidamide inhibitors were designed and synthesized.Although biological evaluation results showed that the compounds displayed poor inhibitory activity towards BACE1,3-phenethylbenzimidamide analogs might be modified as potential BACE1 inhibitors.

The“Chinese Expert Consensus on the Clinical Application of the Chinese Modified Triplet Combination with Irinotecan(CPT-11),Oxaliplatin(LOHP),Continuous Infusion 5-Fluorouracil,and Leucovorin for Colorectal Cancer”

Colorectal cancer is the second most common malignant tumor in China.The FOLFOXIRI regimen,which combines 5-fluorouracil/leucovorin,oxaliplatin,and irinotecan,is a high-intensity and highly effective chemotherapy regimen.However,the original regimen is poorly tolerated in Chinese patients.In order to promote the standardization and rational application of FOLFOXIRI regimen by clinicians in China,the“Chinese Expert Consensus on the Clinical Application of the Chinese Modified Triplet Combination with Irinotecan(CPT-11),Oxaliplatin(LOHP),Continuous Infusion 5-Fluorouracil,and Leucovorin for Colorectal Cancer”was formulated by the Committee of Colorectal Cancer in Chinese Southwest Oncology Group.Based on the mechanism underlying the combined three drugs and toxicity profile,the dosage of Chinese modified FOLFOXIRI(cmFOLFOXIRI)regimen and the management of adverse reactions are proposed.This consensus recommended that the FOLFOXIRI regimen be used in neoadjuvant,conversion,and palliative therapy for colorectal cancer under specific conditions.This consensus aimed to drive the application of cmFOLFOXIRI in the field of colorectal cancer in order to bring benefits to colorectal cancer patients.