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天然药物配合物的研究进展 被引量:4
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作者 郭进宝 《中医研究》 2005年第4期56-59,共4页
综述了天然药物配合物的研究概况、制备、组成和表征、物理化学研究及应用,并对天然药物配合物的发展趋势进行了展望。
关键词 天然药物配合物 制备组成和表征 理化学研究应用 综述
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磺胺类药物金属配合物的研究进展 被引量:1
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作者 杜秀红 崔节虎 +2 位作者 刘隽 行书丽 石科 《化学试剂》 CAS 北大核心 2020年第12期1415-1423,共9页
磺胺类药物配体因具有特殊的芳香环结构、丰富的配位原子以及良好的抗菌、抗癌药物活性等优势,成为新型金属配合物抗菌/抗癌药物研究的热点。重点综述磺胺类药物金属配合物的合成方法、配位模式、抗菌性能和抗癌性能的研究进展,探讨合... 磺胺类药物配体因具有特殊的芳香环结构、丰富的配位原子以及良好的抗菌、抗癌药物活性等优势,成为新型金属配合物抗菌/抗癌药物研究的热点。重点综述磺胺类药物金属配合物的合成方法、配位模式、抗菌性能和抗癌性能的研究进展,探讨合适的合成方法、有效的配位模式、抗菌/抗癌作用规律等。通过对已报道磺胺类药物金属配合物的系统研究,为设计开发高效、低毒、抗耐药性的新型抗菌/抗癌药物奠定基础。 展开更多
关键词 磺胺类药物 磺胺类药物金属配合 抗菌 抗癌 配体
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喹诺酮类Cu(Ⅱ)配合物的电子结构与抗菌活性 被引量:1
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作者 曾兴业 刘小平 李雅萍 《中北大学学报(自然科学版)》 CAS 北大核心 2009年第4期359-364,共6页
对配合物1 Cu(oxo)(phen)Cl;2 Cu(oxo)(bipy)Cl;3 Cu(ppa)(bipy)Cl;4 Cu(ppa)(phen)Cl;5 Cu(pr-norf)(bipy)Cl;6 Cu(pr-norf)(phen)Cl用密度泛函(Density Functional Theory,DFT)法,在B3LYP/LanL2DZ水平上进行了理论计算研究.通过对得... 对配合物1 Cu(oxo)(phen)Cl;2 Cu(oxo)(bipy)Cl;3 Cu(ppa)(bipy)Cl;4 Cu(ppa)(phen)Cl;5 Cu(pr-norf)(bipy)Cl;6 Cu(pr-norf)(phen)Cl用密度泛函(Density Functional Theory,DFT)法,在B3LYP/LanL2DZ水平上进行了理论计算研究.通过对得的到几何结构和电子结构参数分析,发现喹诺酮配合物与DNA结合时,主要是电子(或电子云)从DNA的HOMO转移到配合物的LUMO,且主要是共轭的N-N杂环配体插入DNA的碱基对发生相互作用,同时Cu()与DNA发生配位键合.配合物LUMO能量和前线轨道能级差(ΔEL-H)对其抗菌活性影响显著,LUMO的能量升高和ΔEL-H的降低都有利于配合物抗菌活性增强. 展开更多
关键词 喹诺酮 药物配合物 密度泛函法 抗菌活性
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新型金属钼配合物^(13)C屏蔽张量的测量及计算
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作者 侯广进 王立英 +3 位作者 鲁晓明 郑安民 邓风 叶朝辉 《中国科学(B辑)》 CAS CSCD 北大核心 2004年第1期8-15,共8页
通过固体核磁共振方法,测得了新型的手性八面体钼金属配合物的旋转边带完全分离的13C 2D-PASS谱图,进一步拟合旋转边带的强度,获得了各不等价位13C的屏蔽张量,讨论了抗衡阳离子对邻苯二酚合钼配位阴离子中13C的化学位移各向同性、屏蔽... 通过固体核磁共振方法,测得了新型的手性八面体钼金属配合物的旋转边带完全分离的13C 2D-PASS谱图,进一步拟合旋转边带的强度,获得了各不等价位13C的屏蔽张量,讨论了抗衡阳离子对邻苯二酚合钼配位阴离子中13C的化学位移各向同性、屏蔽张量的影响,分析比较了抗衡阳离子中13C和邻苯二酚合钼配位阴离子中13C化学位移各向异性的大小.基于配合物的晶体结构,分别采用Hartree-Fock和DFT方法进行了量化计算,得到了13CNMR信息,并与实验测量值进行了比较,讨论了量化计算的有效性及误差来源. 展开更多
关键词 金属钼配合 屏蔽张量 测量 固体核磁共振 魔角旋转 化学位移各向异性 金属配合药物
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In Vitro Inhibition of β-Hematin by 2, 4-Diamino-6- Mercaptopyrimidine & 2-Mercaptopyrimidine
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作者 Amneh Aljazzar Qasem Abu-Remeleh +2 位作者 Abd-Alkareem Alsharif Mohammad Abul Haj Mutaz Akkawi 《Journal of Chemistry and Chemical Engineering》 2010年第12期57-61,共5页
Malaria is a disease that has drawn worldwide attention due to the alarming rise of mortality rates particularly in third world countries. During the Plasmodium parasite intraerythrocytic life cycle, metabolic process... Malaria is a disease that has drawn worldwide attention due to the alarming rise of mortality rates particularly in third world countries. During the Plasmodium parasite intraerythrocytic life cycle, metabolic processes include the formation of hemozoin or malaria pigment. This pigment functions in the prevention of oxygen radical-mediated damage to the parasite. Drugs targeting hemozoin formation such as chloroquine and amodaquine are effective and are still used, but recently Plasmodium parasites have become resistant to these drugs, especially against chloroquine. In this study we looked at the potential use of two heterocyclic pyrimidine derivatives as anti-malaria drugs; 2,4-Diamino-6-Mercaptopyrimidine (DAMP) and 2-Mercaptopyrimidine (2-MP). These compounds bear various coordination sites that enable them to react with metal ions to form coordination compounds. We used two methods for testing the inhibition of ferriprotoporphyrin IX (FP) biomineralisation: semi-quantitative microassay used by Deharo, and a quantitative assay used by G. Blaner and M. Akkawi. We report here the finding that (DAMP) has an in vitro inhibitory effect on I%hematin formation at concentrations and magnitude of nearly similar order to that of chloroquine, 2-MP was found to be effective but to a lower degree than DAMP. 展开更多
关键词 2 4-diamino-6-mercaptopyrimidine (DAMP) 2-mercaptopyrimidine (2-MP) [3-hematin Hemozoin Ferriprotopor-phyrin IX (FP) biomineralisation chloroquine diphosphate (CQ).
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Rational design of multi-targeting ruthenium-and platinum-based anticancer complexes
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作者 Wei Zheng 《Science China Chemistry》 SCIE EI CAS CSCD 2016年第10期1240-1249,共10页
Platinum-based anticancer drugs, including cisplatin and its analogues, have played important roles in the clinical treatment of solid tumors over the past 38 years. However, poor selectivity, high toxicity and intrin... Platinum-based anticancer drugs, including cisplatin and its analogues, have played important roles in the clinical treatment of solid tumors over the past 38 years. However, poor selectivity, high toxicity and intrinsic or acquired drug resistance profoundly limit their application, which encourages the development of novel transition metal-based anticancer agents with different mechanisms of action. To this end, transition metal complexes that can simultaneously act on more than one target, termed as single-molecule multi-targeting complexes, have attracted increasing attention because of their enhanced efficacy and diminished chance of drug resistance. In this review, we systematically discuss the recent progress in the development of platinum- and ruthenium-based anticancer agents, in particular the rational design of platinum and ruthenium complexes with multi-targeting features. 展开更多
关键词 anticancer agents metal complexes multi-targeting EGFR-inhibition DNA binding
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