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改用家鸭进行药理血压实验的研究 被引量:3
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作者 马建中 周利玲 《医学理论与实践》 1999年第12期691-692,共2页
本项研究针对传统实验动物犬实验费用高,来源及操作困难的实际情况改用家鸭进行药理血压实验,采用乌拉坦行家鸭腿部静脉麻醉,右颈总静脉输液及给药和颈总动脉插管直接测定血压的方法,取得了与犬相同的实验结果(P>0.05),表明血管活性... 本项研究针对传统实验动物犬实验费用高,来源及操作困难的实际情况改用家鸭进行药理血压实验,采用乌拉坦行家鸭腿部静脉麻醉,右颈总静脉输液及给药和颈总动脉插管直接测定血压的方法,取得了与犬相同的实验结果(P>0.05),表明血管活性药物对犬和家鸭血压的影响无显著差异。该方法可替代犬进行药理血压实验。 展开更多
关键词 家鸭 血压 实验 药理血压实验
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供药理血压实验家鸭品种的研究 被引量:1
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作者 马建中 周利玲 +2 位作者 韩伟 贺显玉 田小娟 《中等医学教育》 2000年第1期26-27,共2页
目的: 本项研究针对传统实验动物犬实验费用高, 来源及操作困难的实情, 探索用不同品种的家鸭替代犬供药理血压实验。方法: 采用乌拉坦行家鸭腿部静脉麻醉, 右颈总静脉输液、给药和颈总动脉插管直接测定血压的方法。结果: 北京鸭... 目的: 本项研究针对传统实验动物犬实验费用高, 来源及操作困难的实情, 探索用不同品种的家鸭替代犬供药理血压实验。方法: 采用乌拉坦行家鸭腿部静脉麻醉, 右颈总静脉输液、给药和颈总动脉插管直接测定血压的方法。结果: 北京鸭组、绍兴鸭组、高邮鸭组、攸县鸭组与犬组实验结果相似(P> 005) , 而番鸭组、洞庭麻鸭组与犬组实验结果差异大(P< 005) 。结论: 北京鸭、绍兴鸭、高邮鸭和攸县鸭等4 展开更多
关键词 血压实验 家鸭 品种 药理血压实验
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POTENT HYPOTENSIVE EFFECTS OF ORPHANIN FQ IN CONSCIOUS STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS 被引量:1
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作者 魏英杰 黄其擎 +4 位作者 朱燕青 米立国 张肇康 汤健 丁金凤 《Chinese Medical Sciences Journal》 CAS CSCD 1998年第2期67-70,共4页
Orphanin FQ(OFQ) or nociceptin is a novel neuropeptide consisting of 17 amino acids. This peptide has a primary structure reminiscent of that of opioid peptide but exhibits an opposite effect to make animals hyperre... Orphanin FQ(OFQ) or nociceptin is a novel neuropeptide consisting of 17 amino acids. This peptide has a primary structure reminiscent of that of opioid peptide but exhibits an opposite effect to make animals hyperreactive. The effect of this new peptide on cardiovascular function are not completely known. The present study was conducted to investigate the effect of intravenous bolus injection of orphanin FQ on mean arterial blood presure (MABP) in conscious stroke-prone spontaneously hypertensive rats (SHRsp). Adult male SHRsp and Wistar normotensive rats (250~300 g body weight, 2. 5~3 months old) were used in this study. The MABP was measured in the conscious state by a tail-cuff method. In SHRsp model, intravenous bolus injection of orphanin FQ or Tyr1-orphanin FQ (0. 5 mg/kg) induced a prolonged and marked reduc- tion in MABP. The maximum changes in MABP were -30. 2±4. 2 mmHg by orphanin FQ and -28. 2± 4. 7 mmHg by Tyr1-orphanin FQ at 10 min after administration,and this effect lasted over 30 min. The Phe1→Tyr substitution in orphanin FQ was found to retain almost fully hypotensive activity. Pretreatment of SHRsp with naloxone-HCI(60 μg/kg), 5 min before the injection of orphanin FQ, did not block the hy- potensive effect of orphanin FQ. Therefore, opioid receptors could not account for the hypotensive effect of orphanin FQ in SHRsp. In Wistar rats, intravenous bolus injection of the same dose of orphanin FQ did not cause a change in MABP. These observations suggest that orphanin FQ is a novel hypotensive peptide and may have some role in the regulation of blood pressure in SHRsp, rather than in normotensive rats. The ex-act underlying mechanisms are waiting to be clarified. 展开更多
关键词 orphanin FQ naloxone 1 stroke-prone spontaneously hypertensive rats (SHR_(sp))
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