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国产环孢素软胶囊的药理试验
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作者 杨体模 《四川生理科学杂志》 1997年第1期45-45,共1页
环孢素软胶囊是环孢素的一个新剂型,其最大虽服用方便,现已广泛应用于临床。我们对环孢素软胶囊进行了药效及急性毒性试验,结果口服环孢素软胶囊40、20mg/Kg/day,每天一次,连续10天,能明显抑制大鼠免疫系统对异种肿瘤S<sub>180<... 环孢素软胶囊是环孢素的一个新剂型,其最大虽服用方便,现已广泛应用于临床。我们对环孢素软胶囊进行了药效及急性毒性试验,结果口服环孢素软胶囊40、20mg/Kg/day,每天一次,连续10天,能明显抑制大鼠免疫系统对异种肿瘤S<sub>180</sub>的排斥反应,且这种免疫抑制作用与剂量有较好的正量效关系。在对移植物抗宿主反应(GVH)试验中. 展开更多
关键词 软胶囊 国产环孢素 药理试 急性毒性 环抱素 排斥反应 移植物抗宿 免疫系统 量效关系 免疫抑制作用
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强心升脉冲剂治疗缓慢性心律失常的临床药理研究
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作者 李仁俊 戚军平 +1 位作者 刘秀芬 于春英 《河北中医药学报》 1994年第3期1-4,共4页
新研制的中成药“强心升脉冲剂”临床验证治疗缓慢性心律失常100例,显效68例(占68%),有效29例(占29%),无效8例(占8%),总有效率97%。与西药常规治疗的对照组30例相比P<0.001。药效学试验表明,本... 新研制的中成药“强心升脉冲剂”临床验证治疗缓慢性心律失常100例,显效68例(占68%),有效29例(占29%),无效8例(占8%),总有效率97%。与西药常规治疗的对照组30例相比P<0.001。药效学试验表明,本品可对抗及保护性对抗利血平所致清醒兔的血压降低和心率减慢作用,对失血性休克的代偿时间、血压及心收缩功能(dp/dt)均有不同程度的保护作用。急、慢性试验中未见毒副反应。 展开更多
关键词 缓慢性心律失常 强心升脉冲剂 临床研究 药理试
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A Bioactive Diterpene from the Chinese Herb Aster souliei 被引量:2
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作者 张永红 王燕玲 +2 位作者 蔡爱华 王勤 程东亮 《Journal of Chinese Pharmaceutical Sciences》 CAS 2004年第4期285-287,共3页
Aster souliei Franch, (Compositae) is a. herbaceous plant distributed innorth China. It has been used in folk medicine as antipyretic, detoxicant, expectorant andantitussive. In an effort to find biologically active c... Aster souliei Franch, (Compositae) is a. herbaceous plant distributed innorth China. It has been used in folk medicine as antipyretic, detoxicant, expectorant andantitussive. In an effort to find biologically active components from Chinese medicinal plants ' ,we have examined the aerial parts of this herb, leading to the isolation of a clerodane-typediterpene, 18, 19-dihydroxy-5α, 10β-neo-cleroda-3, 13 (l4)-dien-16, 15-butenolide (1). In thispaper we report the structural elucidation, and the antitumor and antibacterial activities of thiscompound. It was found that 1 possesses moderate cytotoxicity against human leukemia cells (HL-60)and activity against microorganisms. 展开更多
关键词 aster souliei COMPOSITAE DITERPENE CYTOTOXICITY antibacterial activity
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Formula and Pharmacological Identification of Diarrhea Arresting and Dysentery Treating Dietary Traditional Chinese Herbal Medicine for Livestock
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作者 蔡璐 蒋秀全 +1 位作者 杨何 蔡一鸣 《Agricultural Science & Technology》 CAS 2014年第8期1374-1375,1399,共3页
This study was aimed to develop the Chinese herbal formula with dysentery arresting and antidiarrheal effect. [Method] The Chinese herbal for-mulation was used to carry out the clinical curative effect test and pharma... This study was aimed to develop the Chinese herbal formula with dysentery arresting and antidiarrheal effect. [Method] The Chinese herbal for-mulation was used to carry out the clinical curative effect test and pharmacological test for il livestock. [Results] Curative effect test showed that the formula had good effect on abdominal pain, diarrhea and fecal changes of livestock, and the cure rate reached up to 92%. Pharmacological experiments showed that the formula had sig-nificant inhibitory effect on the gastrointestinal motility of the tested animals, and the diarrhea arresting and dysentery treating effect of the formula was also extremely significant. In addition, the formula was safe for tested animals, proving to be reli-able. [Conclusion] The formula has distinct curative effect on treating white scour of piglets, yel ow scour of piglets, livestock gastroenteritis and lienteric diarrhea, and it can also be used in veterinary clinic, as wel as be used as feed additive. 展开更多
关键词 Chinese herbal formula Curative effect testing Pharmacological testing
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Analysis of initial velocity measurement methods o f pro jectile muzzle
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作者 张斌珍 郝一龙 +2 位作者 李杰 范建英 刘俊 《Journal of Measurement Science and Instrumentation》 CAS 2013年第2期128-131,共4页
Because of the influence of conventio n al ammunition working in high rotation,high overloading,high temperature,hig h pressure and other harsh environments during the launch,it is difficult to m easure the initial ve... Because of the influence of conventio n al ammunition working in high rotation,high overloading,high temperature,hig h pressure and other harsh environments during the launch,it is difficult to m easure the initial velocity of projectile muzzle.This paper analyzes and compar es each sort of characteristics of several ty pical initial velocity measurement methods of projectile muzzle both at home and abroad,and proposes the development trend based on current research and practi cal aplication. 展开更多
关键词 MUZZLE initial velocity MAGNETISM
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Non-Specific Factors Involved in the Treatment: Its Influence on Treatment Adherence
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作者 Gerardo A. Fridman 《Journal of Pharmacy and Pharmacology》 2017年第6期340-348,共9页
Introduction: The effectiveness of treatment depends on the efficacy of the therapy and the level of compliance of the patient. NF (non-specific factors) involved in treatment are all those effects that do not depe... Introduction: The effectiveness of treatment depends on the efficacy of the therapy and the level of compliance of the patient. NF (non-specific factors) involved in treatment are all those effects that do not depend on the pharmacological properties of the drug. Materials and Methods: The job lasted a year. The sample consisted of patients with mental health disorders and was divided into two groups. Treatment compliance was measured with the Morisky-Green Test. Results were compared using the chi square test and relative risk. Results and Discussion: Group A had 23 patients ending 91.3% of them and group B of 22 patients, ending the 77.27%. At the beginning of the study, we found in the group A 0.86 NF/patients while in the group B 0.82 NF/patient. At the end of the study there was a 54.65% decrease in group A while in group B the proportion remained. At the beginning of the study both groups had approximately 40% of compliant patients. Data that remained in the control group rose to 80.95% in group A at the end of the study. Conclusions: The work demonstrates the negative influence of these factors on adherence to treatment. 展开更多
关键词 Adhesion to treatment nonspecific factors influencing treatment health professional patient family environment.
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周心方和他的“白血康口服液”
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作者 朱丹 《健康》 1998年第3期29-29,共1页
看着一张张凝滞了的痛苦的脸被死神定格,面对一双双因失去孩子而痛不欲生的父母们的泪眼,长期从事血液病临床工作的中国中医研究院长城医院血液病科主任周心方大夫心碎了,他深感作为一个血液病科大夫责任之重大,他决心寻求一种新的方法... 看着一张张凝滞了的痛苦的脸被死神定格,面对一双双因失去孩子而痛不欲生的父母们的泪眼,长期从事血液病临床工作的中国中医研究院长城医院血液病科主任周心方大夫心碎了,他深感作为一个血液病科大夫责任之重大,他决心寻求一种新的方法、新的药物以攻克白血病顽疾,以挽救一颗颗天真烂漫求生的童心。 展开更多
关键词 白血康 血康口服液 主任 大夫 白血病 药理试 血液病 中国中医研究院 新的方法 顽疾
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The Safety of Electroacupuncture at Hegu(LI 4) plus Oxytocin for Hastening Uterine Contraction of Puerperants—A Randomized Controlled Clinical Observation
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作者 刘家瑛 韩颖 +7 位作者 张宁 王兵 周宇 杨德利 翟桂荣 王颖 潘俊峰 陈正秋 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2008年第3期163-167,共5页
To investigate the safety of electroacupuncture plus oxytocin for uterine contraction of puerperants. Methods: 276 puerperants with difficult labor were randomly divided into a medication group, treated with intraven... To investigate the safety of electroacupuncture plus oxytocin for uterine contraction of puerperants. Methods: 276 puerperants with difficult labor were randomly divided into a medication group, treated with intravenous dripping of oxytocin, and an acupuncture plus medication group, in the medication group, intravenous dripping of oxytocin was given, and in the other group, acupuncture at bilateral Hegu (LI 4) was added. Heart rate, respiratory frequency, blood pressure of puerperants, fetal heart rate and birth process were observed. Results: During laboring, the indices observed, including heart rate, respiratory frequency, blood pressure, fetal heart rate and birth process, were all in normal range in all of the 276 cases, with better effects in acupuncture plus medication Group M. Conclusions: Electroacupuncture at bilateral Hegu (LI 4) plus intravenous dripping of oxytocin can intensify the uterine contraction, shorten the birth process to avoid probable systemic exhaustion due to excessive consumption, and with no side effects on life signs of the puernerants and newborns. 展开更多
关键词 ELECTROACUPUNCTURE Hegu (LI 4) OXYTOCIN Uterine Contraction Randomized Controlled Trial SAFETY
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