隔姜灸、针刺治疗阳萎症及机理探讨(附310例临床分析)

笔者从1956年开始用针刺隔姜灸疗法治疗阳萎症收到一定的疗效,现将1971年至1988年的310例临床资料分析如下。临床资料一、一般资料本组20岁以下4例,21岁～30岁159例,31岁～40岁112例,41岁以上35例,其中最小17岁,最大66岁。病程最短4天,最长27年。

用上骱手法救治肌萎症医案1例浅析

1991年5月．我因探望一住院亲属而碰到一位全身肌肉全部萎缩的患者。他叫周某某，技工，当年28岁，已婚2年。初见此人，吃了一惊，见不到一点肌肉，全身骨瘦如柴，只有双眼皮能眨，双眼球能转，嘴巴能说话，手指、足趾能微动。经了解生命指征正常，全身无疼痛不适，但是全身无力。身高1．67米，体重36．5k，活脱脱一具活着的木乃伊。我从未见过这么干枯无肉的活人。据周自述：“起初在5个半月前，身体数处肌肉关节有些酸疼，2天后痛疼加重，当时诊断疑为关节炎，第3天午后在市人民医院门诊就诊时，

阳萎症治疗的最近进展

阴茎海绵体血流的调节勃起系指阴茎海绵体内血液潴留、海绵体内压力上升的现象。这种血液潴留是由于流入海绵体内的血量增加而流出量减少的缘故。最近Banya等报告,阴茎海绵体内存在着毛细血管系统和海绵体窦两个循环系统,并可能存在着某种结构使血液在非勃起时流入毛细血管,而在勃起时流入海绵体窦。作者根据阴茎海绵体平滑肌对各种药物的反应,基本弄清了有关阴茎海绵体收缩和舒张的机制。

葆春精胶囊补肾壮阳的实验研究

采用小鼠阳虚模型和肾虚(去势)模型探讨了葆春精胶囊的补肾壮阳作用机制。实验结果表明,葆春精胶囊能显著地提高阳虚小鼠在低温环境中的游泳存活时间,并可拮抗氢可所致的小鼠脏器重量减轻,与模型组比较,其胸腺、肾指数增加明显。明显提高去势小鼠阴茎对外部刺激的兴奋性及敏感性,缩短阴茎勃起潜伏期,显著增加肾虚小鼠包皮腺、精囊腺前列腺及提肛肌指数。并能明显提高正常雄性小鼠的交配能力和精子数量。提示葆春精胶囊对阳萎有较好的治疗作用。

补肾强骨汤联合鲑鱼降钙素治疗中老年骨质疏松随机平行对照研究

[目的]观察补肾强骨汤联合鲑鱼降钙素治疗中老年骨质疏松疗效。[方法]使用随机平行对照方法,将60例住院及门诊患者按就诊顺序号方法简单随机分两组。对照组30例鲑鱼降钙素,200iU鼻喷,隔天1次。治疗组30例补肾强骨汤(桑寄生、杜仲、补骨脂、骨碎补各15g,山药20g,山茱萸15g,菟丝子20g,牛膝15g,蜈蚣2条,伸筋草15g,地龙2条,黄芪30g,乳香15g,没药10g),1剂/d,水煎200m L,早晚口服;鲑鱼降钙素治疗同对照组。连续治疗2个月为1疗程。观测临床症状、骨密度、不良反应。连续治疗6疗程,判定疗效。[结果]治疗组显效3例,有效23例,无效4例,总有效率90.00%。对照组显效2例,有效17例,无效11例,总有效率63.33%。治疗组疗效优于对照组(P<0.05)。骨密度两组均有提升(P<0.01,P<0.05),治疗组提升优于对照组(P<0.01)。[结论]补肾强骨汤联合鲑鱼降钙素治疗中老年骨质疏松,疗效满意,无严重不良反应,值得推广。

金属在不同疾病中的作用

研究数据表明 ,金属离子反应可能是包括阿尔茨海默病、肌萎缩侧索硬化症、沅蛋白病、白内障、线粒体疾病以及帕金森病在内的众多疾病的共同发病基础 (公分母 ) ,在这些疾病中 ,某一种蛋白质与氧化还原反应金属离子之间产生的异常反应 ,促进了活性氧基团的形成。尤其是抗氧化剂 - Cu/Zn超氧化物歧化酶的强力催化氧化还原反应的活性 ,怎么能转化为促氧化活性。在最近的报道中 ,有一种观点引起了巨大的反响 ,即分别与阿尔茨海默病和沅蛋白病相关的 Aβ和 Pr

铜锌超氧化物歧化酶的突变与神经退行性紊乱的生物无机化学

本文简单介绍了铜锌超氧化物歧化酶的结构、功能及其相互关系 ,较为详细地讨论了与神经退行性紊乱 ,尤其是与肌萎性脊髓侧索硬化症有关的铜锌超氧化物歧化酶突变体的生物无机化学的研究进展 ,提出由该酶突变而引起的蛋白质局部结构变化和金属离子缺失 ,以及由此导致的氧化损伤和聚集作用可能是导致神经退行性紊乱的主要原因之一。

艺术何以生存

高速发展的电子工业时代的物质生产水平极大地刺激着人们的物质享受的欲望。眼前那瞬息万变不断花样翻新的享乐方式和生活方式简直使人们整天疲于追踪、应顾不暇。有人说现代生活就好象有一条鞭子在不停地抽打着人们拼命地向前跑,其实很多时候都是人们自己的欲望在抽打着自己往前奔。

Effect of honey on bacterial translocation and intestinal morphology in obstructive jaundice

AIM:To evaluate the effects of honey on bacterial translocation and intestinal villus histopathology in experimental obstructive jaundice.METHODS:Thirty Wistar-Albino rats were randomly divided into three groups each including 10 animals:group Ⅰ,sham-operated;group Ⅱ,ligation and section of the common bile duct(BDL);group Ⅲ,bile duct ligation followed by oral supplementation of honey(BDL+honey) 10 g/kg per day.Liver,blood,spleen,mesenteric lymph nodes,and ileal samples were taken for microbiological,light and transmission electrone microscopic examination.RESULTS:Although the number of villi per centimeter and the height of the mucosa were higher in sham group,there was no statistically significant difference between sham and BDL + honey groups(P>0.05).On the other hand,there was a statistically significant difference between BDL group and other groups(P<0.05).The electron microscopic changes werealso different between these groups.Sham and honey groups had similar incidence of bacterial translocation(P>0.05).BDL group had significantly higher rates of bacterial translocation as compared with sham and honey groups.Bacterial translocation was predominantly detected in mesenteric lymph nodes.CONCLUSION:Supplementation of honey in presence of obstructive jaundice ameliorates bacterial translocation and improves ileal morphology.

Intraperitoneal administration of gonadotropin-releasing hormone-PE40 induces castration in male rats

AIM： To evaluate the long-term effects of gonadotropinreleasing hormone （GnRH）-based vaccine on levels of GnRH antibody and testosterone, and vaccine-induced immunocastration on sexual behavior of male rats. METHODS： The rats were treated with GnRH-PE40 intraperitoneally every other day for 12 wk. GnRH antibody and testosterone level in rat blood were determined by EUSA and radioimmunoassay, respectively. Morphological changes in testes and sexual behavior of rats were evaluated. RESULTS： GnRH-PE40 induced a high production in GnRH antibody, decreased the serum testosterone level, testis atrophy and sexual function in rats. CONCLUSION： Intraperitoneal administration of GnRH- PE40 produces structural and functional castration of male rat reproductive system by inducing anti-GnRH antibody.

Effects of the myeloperoxidase 463 gene polymorphisms on development of atrophy in H pylori infected or noninfected gastroduodenal disease

AIM： To investigate the relationship between myeloperoxidase polymorphisms as a host-related factor and atrophy caused by H pylori. METHODS： Our study enrolled 77 patients. Biopsy materials obtained during gastrointestinal endoscopies were evaluated for the presence of H pylori. Polymerase chain reaction-restriction fragment length polymorphism assay was used to characterize myeloperoxidase genothpes. RESULTS： Forty four patients （57.1%） were lip （＋） and 33 （42.9%） were Hp （-）. Sixty six （85.7%） had GG genotype, 10 （12.9%） had GA genotype and 1 （1.29%） had AA genotype. The change in atrophy in relation to neutrophil infiltration was significant in Hp （＋） patients （P = 0.0001）. The change in atrophy in relation to neutrophil infiltration in patients with GG genotype was significant （P = 0.002）. However, the change in atrophy in relation to neutrophil infiltration was not significiant in patients with Hp （＋） GG genotype （r = 0.066, P = 0.63）. CONCLUSION： Myeloperoxidase genotype is critical for development of atrophy in relation to the severity of inflammation. However, it is interesting to note that, H pylori does not show any additive effect on development of atrophy.

Umbilical cord mesenchymal stem cell transplantation for the treatment of Duchenne muscular dystrophy

Due to their relative abundance,stable biological properties and excellent reproductive activity,umbilical cord mesenchymal stem cells have previously been utilized for the treatment of Duchenne muscular dystrophy,which is a muscular atrophy disease.Three patients who were clinically and pathologically diagnosed with Duchenne muscular dystrophy were transplanted with umbilical cord mesenchymal stem cells by intravenous infusion,in combination with multi-point intramuscular injection.They were followed up for 12 months after cell transplantation.Results showed that clinical symptoms significantly improved,daily living activity and muscle strength were enhanced,the sero-enzyme,electromyogram,and MRI scans showed improvement,and dystrophin was expressed in the muscle cell membrane.Hematoxylin-eosin staining of a muscle biopsy revealed that muscle fibers were well arranged,fibrous degeneration was alleviated,and fat infiltration was improved.These pieces of evidence suggest that umbilical cord mesenchymal stem cell transplantation can be considered as a new regimen for Duchenne muscular dystrophy.

Risk for gastric neoplasias in patients with chronic atrophic gastritis:A critical reappraisal

Chronic atrophic gastritis （CAG） is an inflammatory condition characterized by the loss of gastric glandular structures which are replaced by connective tissue （non-metaplastic atrophy） or by glandular structures inappropriate for location （metaplastic atrophy）. Epidemiological data suggest that CAG is associated with two different types of tumors： Intestinal-type gastric cancer （GC） and type I gastric carcinoid （T I GC）. The pathophysiological mechanisms which lead to the development of these gastric tumors are different, It is accepted that a multistep process initiating from Helico- bacterpylori-related chronic inflammation of the gastric mucosa progresses to CAG, intestinal metaplasia, dysplasia and, finally, leads to the development of GC. The T I GC is a gastrin-dependent tumor and the chronic elevation of gastrin, which is associated with CAG, stimulates the growth of enterochromaffin-like cells with their hyperplasia leading to the development of T I GC. Thus, several events occur in the gastric mucosa before the development of intestinatype GC and/ or T I GC and these take several years. Knowledge ofCAG incidence from superficial gastritis, its prevalence in different clinical settings and possible risk factors as- sociated with the progression of this condition to gastric neoplasias are important issues. This editorial intends to provide a brief review of the main studies regarding incidence and prevalence of CAG and risk factors for the development of gastric neoplasias.

Importance of gastrin in the pathogenesis and treatment of gastric tumors

In addition to regulating acid secretion, the gastric antral hormone gastrin regulates several important cellular processes in the gastric epithelium including proliferation, apoptosis, migration, invasion, tissue remodelling and angiogenesis. Elevated serum concentrations of this hormone are caused by many conditions, particularly hypochlorhydria (as a result of autoimmune or Helicobacter pylori (H pylori)-induced chronic atrophic gastritis or acid suppressing drugs) and gastrin producing tumors (gastrinomas). There is now accumulating evidence that altered local and plasma concentrations of gastrin may play a role during the development of various gastric tumors. In the absence of H pylori infection, marked hypergastrinemia frequently results in the development of gastric enterochromaffi n cell-like neuroendocrine tumors and surgery to remove the cause of hypergastrinemia may lead to tumor resolution in this condition. In animal models such as transgenic INS-GAS mice, hypergastrinemia has also been shown to act as a cofactor with Helicobacter infection during gastric adenocarcinoma development. However, it is currently unclear as to what extent gastrin also modulates human gastric adenocarcinoma development. Therapeutic approaches targeting hypergastrinemia,such as immunization with G17DT, have been evaluated for the treatment of gastric adenocarcinoma, with some promising results. Although the mild hypergastrinemia associated with proton pump inhibitor drug use has been shown to cause ECL-cell hyperplasia and to increase H pylori-induced gastric atrophy, there is currently no convincing evidence that this class of agents contributes towards the development of gastric neuroendocrine tumors or gastric adenocarcinomas in human subjects.

Gastric carcinoids:Between underestimation and overtreatment

Gastric carcinoids(GCs),which originate from gastric enterochromaffin-like(ECL) mucosal cells and account for 2.4% of all carcinoids,are found increasingly in the course of upper gastrointestinal tract endoscopy.Current nosography includes those occurring in chronic conditions with hypergastrinemia,as the type 1 associated with chronic atrophic gastritis,and the type 2 associated with Zollinger-Ellison syndrome in multiple endocrine neoplasia type 1,and type 3,which is unrelated to hypergastrinemia and is frequently malignant,with distant metastases.The optimal clinical approach to GCs remains to be elucidated,depending upon type,size and number of carcinoids.While there is agreement concerning the treatment of type 3 carcinoids,for types 1 and 2,current possibilities include simple surveillance,endoscopic polypectomy,surgical excision,associated or not with surgical antrectomy,or total gastrectomy.Moreover,the recent introduction of somatostatin analogues represents a therapeutic option of possibly outstanding relevance.

A Single-Finger Operated Noncontact User Interface

A noncontact user interface using image processing for people with neuromuscular diseases is presented in this paper. The user interface is composed of a Web camera and a PC, and allows users to manipulate the PC using small movements of single finger. By using image processing techniques with the Web camera, the finger is appropriately detected from the images captured by it. Control boxes for pointing and text input functions are also made. To verify performances of the interface, some tasks are experimentally performed by three able-bodied subjects and a person suffering from spinal muscular atrophy. It was clear from the experimental results that all the subjects could smoothly nerforrn the t,~k~