Three new ent-kaurene diterpenoids, adenanthins N, 0 and P (1-3), and four known diterpenoids, leucophyllin E (4), glabcensin C (5), adenanthin A (6), leucophyllin B (7), together with a highly unsaturated fatty acid,...Three new ent-kaurene diterpenoids, adenanthins N, 0 and P (1-3), and four known diterpenoids, leucophyllin E (4), glabcensin C (5), adenanthin A (6), leucophyllin B (7), together with a highly unsaturated fatty acid, 9,16-dioxo-10,1 2,14-octadeca-trienoic acid (8), were isolated from Isodon adenanthus (Diels) Kudo. The structure of compound 4 was revised accordingly. Compound I showed significant cytotoxic activity against K562 cells with IC50 = 0.45 mug/mL.展开更多
Ferruginol, a phenolic diterpenoid, was isolated from Prumnupitys andina, a Chilean native plant, as the main compound. Ferruginol has displayed an interesting range of biological activities such as in vitro anti-infl...Ferruginol, a phenolic diterpenoid, was isolated from Prumnupitys andina, a Chilean native plant, as the main compound. Ferruginol has displayed an interesting range of biological activities such as in vitro anti-inflammatory activity. Aim of this research is to evaluate the dermal anti-inflammatory activity of ferruginol, using in vivo models at first time. Ferruginol was subjected to topical assays for the inhibition of inflammation elicited by AA （arachidonic acid） or TPA （phorbol ester） in the murine model. The topical anti-inflammatory activity was evaluated in vivo using groups of 8 animals were treated with a single dose of ferruginol, equimolar doses with regard to the reference drugs, indomethacin and nimesulide. We showed a chemical data were consistent with a type-abietane diterpenoid known as ferruginol. Ferruginol showed topical anti-inflammatory activity at 21.0% and 20.5% in AA and TPA models, respectively. Our results provide data to support further investigations about ferruginol, a type-abietane diterpenoid, as a potential anti-inflammatory agent.展开更多
文摘Three new ent-kaurene diterpenoids, adenanthins N, 0 and P (1-3), and four known diterpenoids, leucophyllin E (4), glabcensin C (5), adenanthin A (6), leucophyllin B (7), together with a highly unsaturated fatty acid, 9,16-dioxo-10,1 2,14-octadeca-trienoic acid (8), were isolated from Isodon adenanthus (Diels) Kudo. The structure of compound 4 was revised accordingly. Compound I showed significant cytotoxic activity against K562 cells with IC50 = 0.45 mug/mL.
文摘Ferruginol, a phenolic diterpenoid, was isolated from Prumnupitys andina, a Chilean native plant, as the main compound. Ferruginol has displayed an interesting range of biological activities such as in vitro anti-inflammatory activity. Aim of this research is to evaluate the dermal anti-inflammatory activity of ferruginol, using in vivo models at first time. Ferruginol was subjected to topical assays for the inhibition of inflammation elicited by AA （arachidonic acid） or TPA （phorbol ester） in the murine model. The topical anti-inflammatory activity was evaluated in vivo using groups of 8 animals were treated with a single dose of ferruginol, equimolar doses with regard to the reference drugs, indomethacin and nimesulide. We showed a chemical data were consistent with a type-abietane diterpenoid known as ferruginol. Ferruginol showed topical anti-inflammatory activity at 21.0% and 20.5% in AA and TPA models, respectively. Our results provide data to support further investigations about ferruginol, a type-abietane diterpenoid, as a potential anti-inflammatory agent.
