萜烯二醇合成工艺的研究

以四氢呋喃为溶剂,65℃下,用氢化铝锂还原萜烯马来酸酐,得到还原产物萜烯二醇。通过研究反应温度与时间、不同的溶剂、不同的还原剂等因素对合成反应的影响,确定了最佳合成反应条件,并经FT-IR、GC-MS表征了萜烯二醇的化学结构,同时探讨了还原过程的反应机理。该化合物为淡黄色固体,其羟值为:420.5mgKOH/g.

橄榄油中多种营养物质在常温储存过程中的含量衰减规律研究

利用液质联用技术系统研究了叶黄素、α-生育酚、γ-生育酚、高根二醇、麦角固醇、岩藻甾醇、菜油甾醇、豆甾醇、β-谷甾醇9种营养物质在橄榄油常温储存过程中的含量衰减规律。评估了光照、氧气等因素对9种营养物质含量衰减规律的影响,对比了9种营养物质的稳定性差异。结果表明:光照比氧气对橄榄油中各营养物质的稳定性影响更大,其中α-生育酚对光照极为敏感;高根二醇、岩藻甾醇、菜油甾醇、豆甾醇、β-谷甾醇5种营养物质的稳定性较好,而γ-生育酚、α-生育酚、叶黄素、麦角固醇则相对不稳定。

垂穗石松的化学成分研究

从垂穗石松Palhinheacernua中分得6个化合物，经理化常数测定和光谱分析鉴定Ⅰ为羟基垂石松碱，Ⅱ为千层塔萜烯二醇，Ⅱ为21－表千层塔萜二醇，Ⅳ为垂石松酸甲，Ⅴ为伸筋草萜三醇，Ⅵ为16－氧代伸筋草萜三醇。

Anti-Inflammatory Activity of Ferruginol from Prumnupitys andina

Ferruginol, a phenolic diterpenoid, was isolated from Prumnupitys andina, a Chilean native plant, as the main compound. Ferruginol has displayed an interesting range of biological activities such as in vitro anti-inflammatory activity. Aim of this research is to evaluate the dermal anti-inflammatory activity of ferruginol, using in vivo models at first time. Ferruginol was subjected to topical assays for the inhibition of inflammation elicited by AA （arachidonic acid） or TPA （phorbol ester） in the murine model. The topical anti-inflammatory activity was evaluated in vivo using groups of 8 animals were treated with a single dose of ferruginol, equimolar doses with regard to the reference drugs, indomethacin and nimesulide. We showed a chemical data were consistent with a type-abietane diterpenoid known as ferruginol. Ferruginol showed topical anti-inflammatory activity at 21.0% and 20.5% in AA and TPA models, respectively. Our results provide data to support further investigations about ferruginol, a type-abietane diterpenoid, as a potential anti-inflammatory agent.

黔产金钗石斛中1个新的杜松烷型倍半萜

目的研究贵州道地药材金钗石斛Dendrobium nobile的化学成分。方法采用硅胶、MCI柱色谱及制备液相色谱等方法进行分离纯化,经质谱和核磁共振等波谱技术进行结构鉴定。结果从贵州道地药材金钗石斛茎的乙醇提取物中分离得到1个新的倍半萜类化合物,鉴定为δ-杜松萜烯-12,14-二醇(1)。结论化合物1为新化合物。