背景随着全球人口老龄化和非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)增长,老年NAFLD人群特点的研究尤为重要.目的观察老年NAFLD患者的营养状态和能量代谢特点.方法回顾性分析2017-01/2019-01天津市第三中心医院消化...背景随着全球人口老龄化和非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)增长,老年NAFLD人群特点的研究尤为重要.目的观察老年NAFLD患者的营养状态和能量代谢特点.方法回顾性分析2017-01/2019-01天津市第三中心医院消化科就诊的NAFLD老年患者118例,进行人体成分分析仪分析及应用代谢车评估营养及能量代谢指标,与老年非脂肪肝组进行比较.统计分析中正态分布计量资料采用独立样本t检验,非正态分布计量资料采用Mann-Whitney U检验,二元Logistic回归分析老年NAFLD发生的危险因素.结果人体成分分析显示老年NAFLD组腰臀脂肪比、体脂肪含量较老年非脂肪肝组明显增加(腰臀脂肪比0.95 vs 0.92,体脂肪27.20 kg vs 19.60 kg,P<0.005);代谢车测定结果显示老年NAFLD组静息能量消耗均高于老年非脂肪肝组(1769.00 kcal/d vs 1323.00 kcal/d,P<0.05);进一步比较老年NAFLD患者轻度脂肪肝组与中重度脂肪肝组,轻度脂肪肝组体脂肪、腰臀脂肪比、基础代谢、静息能量消耗明显低于中重度脂肪肝患者.结论在老年NAFLD患者中存在营养失衡和能量代谢紊乱,随脂肪肝程度加重更为显著,通过人体成分分析仪和代谢车以综合评价和监测老年NAFLD患者的营养及能量代谢状态,为疾病干预治疗提供依据.展开更多
Leptin is a new obese gene (ob) product in animal, which related with feed intake, energy balance, lipid metabolism, reproduction and so on. The advances were summarized on structure, secretion and function of leptin....Leptin is a new obese gene (ob) product in animal, which related with feed intake, energy balance, lipid metabolism, reproduction and so on. The advances were summarized on structure, secretion and function of leptin. The effects and regulation of energy nutrient on the expression level of leptin were introduced, and the application prospects in aquatic animals were also discussed. Obesity is not the main problem of aquatic animal production, but the improvement of carcass quality and reproduction is the central goal of aquaculture. Some study indicated, leptin has had the remarkable regulative effect on lipid metabolism and neuroendocrine, the regulation of feed intake and energy balance could promote muscle produce, reproduction, milk secretion etc, at the same time the leptin expression of ob gene was affected and regulated by adipose tissue volume and cell size, energy intake, some hormones and so on. Therefore, ob gene and leptin not only have influence on gene effect of adipose deposit and improvement of carcass quality in aquaculture, but also show the potential that the Leptin expression could be regulated through nutritional ways. Energy intake、energy utilization and lipid metabolism could be regulated by feed intake, energy assembling of diet, gain range and so on, consequently which regulated the expression of ob gene and the output,the sensitivity,the receptor activity of its product leptin, ultimately the objective of improvement of carcass quality, increase of reproduction, regulation of physiological metabolism and healthy protection could come true. To get this goal is possible and has important theory significance and practical value.展开更多
文摘背景随着全球人口老龄化和非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)增长,老年NAFLD人群特点的研究尤为重要.目的观察老年NAFLD患者的营养状态和能量代谢特点.方法回顾性分析2017-01/2019-01天津市第三中心医院消化科就诊的NAFLD老年患者118例,进行人体成分分析仪分析及应用代谢车评估营养及能量代谢指标,与老年非脂肪肝组进行比较.统计分析中正态分布计量资料采用独立样本t检验,非正态分布计量资料采用Mann-Whitney U检验,二元Logistic回归分析老年NAFLD发生的危险因素.结果人体成分分析显示老年NAFLD组腰臀脂肪比、体脂肪含量较老年非脂肪肝组明显增加(腰臀脂肪比0.95 vs 0.92,体脂肪27.20 kg vs 19.60 kg,P<0.005);代谢车测定结果显示老年NAFLD组静息能量消耗均高于老年非脂肪肝组(1769.00 kcal/d vs 1323.00 kcal/d,P<0.05);进一步比较老年NAFLD患者轻度脂肪肝组与中重度脂肪肝组,轻度脂肪肝组体脂肪、腰臀脂肪比、基础代谢、静息能量消耗明显低于中重度脂肪肝患者.结论在老年NAFLD患者中存在营养失衡和能量代谢紊乱,随脂肪肝程度加重更为显著,通过人体成分分析仪和代谢车以综合评价和监测老年NAFLD患者的营养及能量代谢状态,为疾病干预治疗提供依据.
文摘Leptin is a new obese gene (ob) product in animal, which related with feed intake, energy balance, lipid metabolism, reproduction and so on. The advances were summarized on structure, secretion and function of leptin. The effects and regulation of energy nutrient on the expression level of leptin were introduced, and the application prospects in aquatic animals were also discussed. Obesity is not the main problem of aquatic animal production, but the improvement of carcass quality and reproduction is the central goal of aquaculture. Some study indicated, leptin has had the remarkable regulative effect on lipid metabolism and neuroendocrine, the regulation of feed intake and energy balance could promote muscle produce, reproduction, milk secretion etc, at the same time the leptin expression of ob gene was affected and regulated by adipose tissue volume and cell size, energy intake, some hormones and so on. Therefore, ob gene and leptin not only have influence on gene effect of adipose deposit and improvement of carcass quality in aquaculture, but also show the potential that the Leptin expression could be regulated through nutritional ways. Energy intake、energy utilization and lipid metabolism could be regulated by feed intake, energy assembling of diet, gain range and so on, consequently which regulated the expression of ob gene and the output,the sensitivity,the receptor activity of its product leptin, ultimately the objective of improvement of carcass quality, increase of reproduction, regulation of physiological metabolism and healthy protection could come true. To get this goal is possible and has important theory significance and practical value.