红花与葛根素注射液治疗突发性聋疗效观察

目的:探讨治疗突发性聋的有效方法。方法:168例突发性聋患者随机分成红花、葛根素组(治疗组86例)和复方丹参组(对照组82例),分别使用红花、葛根素注射液和复方丹参液治疗。结果:治疗组有效率为91.8%,对照组为68.2%,两组比较具差异有显著性。结论:红花和葛根素液是治疗突发性聋的有效药物,优于复方丹参液。

心绞痛患者注射葛根素葡萄糖液后血液流变学和细胞因子及其受体的变化

目的 :探讨心绞痛患者注射葛根素葡萄糖液后血液流变学和细胞因子及其受体的变化。方法 :采用葛根素注射液 0 4～ 0 6g/次静滴。①用常规方法进行血流变测定 ;②应用ELISA法进行细胞因子及其受体测定。结果 :心绞痛患者静滴葛根素葡萄糖注射液后 ,其全血粘度、血浆粘度、全血还原粘度低切 ,红细胞压积 ,血小板聚集率及纤维蛋白原均有明显降低 (P <0 0 5 )。结论 :葛根素葡萄糖注射液能改善心绞痛患者的微循环。

葛根素注射液治疗不稳定型心绞痛疗效观察

目的 观察葛根素注射液治疗不稳定型心绞痛(UAP)的临床疗效。方法78例UAP患者随机分为2组。葛根素组(40例)在对照组(38例)西药常规治疗的基础上,加用葛根素注射液静滴,2疗程后,分别观察2组患者治疗前后的心绞痛发作频率及硝酸甘油用量的变化;检测静息心电图和血液流变学指标变化。结果 葛根素在缓解心绞痛总有效率(89.5％)、心绞痛被控制所需时间(平均5～6d)、改善异常心电图及血液流变学指标和降低硝酸甘油用量(0.45±0.15mg·d^(-1))等方面均显著优于对照组(分别为 61.1％,8～9d1.25±0.19mg·d^(-1)),葛根素组和对照组相比有统计学意义(P<0.05)。结论 葛根素治疗UAP疗效优于常规西药冶疗。

以溶解度与刺激性为指标筛选葛根素滴鼻液溶剂及增溶剂

该实验利用平衡法测定了葛根素在不同溶剂及增溶剂中的平衡溶解度,采用蟾蜍在体纤毛毒性实验考察了溶剂和增溶剂的纤毛毒性,采用大鼠长期鼻黏膜刺激性实验考察溶剂和增溶剂对鼻黏膜的刺激性。溶解度测定显示30%聚乙二醇200,10%KolliphorHS 15联用能使葛根素的溶解度达到56.44 g·L-1。以生理盐水为阴性对照,公认的有纤毛毒性的去氧胆酸钠为阳性对照,观察30%聚乙二醇200,30%聚乙二醇400,10%KolliphorHS 15及30%聚乙二醇200与10%KolliphorHS 15合用对蟾蜍上颚纤毛的影响,记录纤毛持续运动时间,结果显示30%聚乙二醇200及10%KolliphorHS 15与生理盐水相比纤毛持续运动时间没有显著性差异。以生理盐水为对照,研究纤毛毒性较小的30%聚乙二醇200及10%KolliphorHS 15的大鼠长期鼻黏膜刺激性,实验结果显示该溶剂和增溶剂对鼻黏膜刺激性较小,与生理盐水相比鼻黏膜上皮厚度及刺激指数没有显著性差异。30%聚乙二醇200和10%KolliphorHS 15能满足葛根素滴鼻液溶解度要求,纤毛毒性和刺激性小,可以作为葛根素滴鼻液较优的溶剂和增溶剂。

Efficacy and safety of puerarin injection in treatment of diabetic peripheral neuropathy: a systematic review and Meta-analysis of randomized controlled trials

OBJECTIVE: To systematically evaluate the clinical efficacy and safety of puerarin injection in the treatment of diabeticperi pheral neuropathy(DPN).METHODS: Randomized controlled trials investigating the efficacy of puerarin injection on DPN were searched for in China National Knowledge Infrastructure Database, Chinese Scientific Journals Database, Wanfang Database, Chinese Biomedical Literature Database, PubMed, and Cochrane Library from establishment to April 30.Two reviewers independently retrieved and extracted the information.The included studies were assessed by the Cochrane risk of bias and analyzed by Review Manager 5.2 software.RESULTS: Twenty-two studies involving 1664 participants were included. The quality of the studies was found to be relatively low. Meta-analysis showed that puerarin injection combined with western medication was more effective than conventional therapy for rate, nerve conduction velocity(NCV), and hemorheology index. Six adverse drug reactions(ADRs) from puerarin injection were reported in two studies. Reactions included facial flushing, palpitations, and pain at infusion locations. However,noserious ADRs were reported.CONCLUSION: Puerarin injection was effective for the treatment of DPN. Puerarin can improve the total effective rate, correct NCV that was decreased by diabetes, and improve the hemorheology index.Puerarin was also relatively safe clinically. However,since the articles included in the study were not high-quality, more studies should be conducted to strengthen their findings.