葛根素针致速发喉头水肿反应1例

患者,男,57岁,因急性下壁正后壁心肌梗塞于1998年10月5日收住院,既往有高血压病20余年,最高血压25271463ｋＰａ,规律服用美托洛尔、苯磺酸氨氯地平片,血压控制在(1862～1995)(1064～1197)ｋＰａ。一年前所患脑梗塞已痊愈,无高血脂、糖尿病史,无肝炎、结核病史,无药物与食?..

葛根素针治疗急性脑梗死的疗效观察

目的:探讨葛根素针治疗急性脑梗死的临床疗效。方法:将应用葛根素针治疗的58例急性脑梗死的患者与同期常规治疗的58例急性脑梗死的患者进行对比,观察疗效。结果:治疗组总有效率93.1%,明显优于对照组84.5%(P<0.01)。两组均未见明显的不良反应。结论:葛根素针治疗急性脑梗死,具有安全性高、不良反应少、疗效好等优点。

葛根素冻干粉针治疗不稳定型心绞痛的短期疗效观察——附30例报告

目的 观察葛根素冻干粉针 (麦普宁 )治疗不稳定型心绞痛 (Unstableanginapectoris.UAP)的临床疗效。 方法 将 6 0例UAP患者随机分为治疗组 30例和对照组 30例。对照组采用常规治疗。治疗组在常规治疗的基础上加用葛根素冻干粉针 4 0 0mg加入 5 %葡萄糖液 2 5 0ml中静脉滴注 ,疗程均为 14d。 结果 治疗组的总有效率(93% )优于对照组 (6 6 % ) ,差异有统计学意义 (P <0 .0 5 )。治疗组治疗前后心电图 12导联中ST段下降导联数(NST)及 12导联中ST段压低数值总和 (ΣST)均有明显改善 (P <0 .0 5 ) ,随访心绞痛患者 6～ 18个月 ,未发现明显不良反应。结论 葛根素冻干粉针剂能有效减少心绞痛发作 ,应用简单、监测方便 ,可降低心肌梗死发生率。

梓葛冻干粉针中葛根素在大鼠肝肾的分布

目的:考察梓葛冻干粉针中葛根素在大鼠肝、肾的分布过程,探讨梓葛冻干粉针的安全性。方法:设梓葛冻干粉针药物组和葛根素冻干粉针对照组,按葛根素剂量26.7 mg.kg-1,经大鼠尾静脉给药。采用高效液相色谱法测定给药后5,10,20,30,45,60,120 min,大鼠肝、肾组织中葛根素的浓度。结果:药物组中葛根素在肾脏的峰浓度Cmax为58.12μg.g-1,药-时曲线下面积AUC0-2 h为26.24μg.h.g-1,平均滞留时间MRT0-2 h为0.39 h;对照组中葛根素在肾脏的Cmax71.28μg.g-1,AUC0-2 h35.24μg.h.g-1,MRT0-2 h0.42 h。与对照组相比,药物组大鼠肾脏中的葛根素Cmax和AUC0-2 h明显降低(P<0.05),达峰时间tmax和MRT0-2 h无显著性差异。2组中葛根素在肝脏的tmax,Cmax,AUC0-2 h和MRT0-2 h均无显著性差异。结论:与葛根素冻干粉针相比,梓葛冻干粉针中葛根素在肾脏的分布明显降低,消除无明显变化;在肝脏的分布与消除均无明显变化。说明梓醇可降低葛根素在肾脏中的分布,梓葛冻干粉针比葛根素粉针对于肾脏安全性更高。

Treatment of 65 Cases of Cervical Vertigo Treated by Acupuncture plus Medication

Objective： To investigate the efficacy of acupuncture plus puerarin and glucose injection for treating cervical vertigo. Method： 110 cases of cervical vertigo were divided into the treatment group and control group. 65 cases in the treatment group were treated by acupuncture plus puerarin and glucose injection and 45 cases in the control group were treated with Western medications. Results： In the treatment group, the results showed cure in 33 cases, effect in 29 cases and failure in 3 cases, and the total effective rate in 95.38%. In the control group, the results showed cure in 12 cases, effect in 23 cases and failure in 10 cases, and the total effective rate in 77.87%. In comparison of the total effective rate between the two groups, the treatment group was better than the control group （P〈0.01）. Conclusion： The therapeutic effect is better in the treatment of cervical vertigo by acupuncture plus herbal medicine.than that by Western medications.