老年期痴呆有广义与狭义的两种概念。狭义仅指在老年期(60岁以后)开始发病的痴呆。广义的则指那些凡是在老年期见到的各种痴呆的总称,即包括那些在老年期以前就已经发病而又持续至老年期的各种疾病所致的痴呆。根据现有的病因学和病理...老年期痴呆有广义与狭义的两种概念。狭义仅指在老年期(60岁以后)开始发病的痴呆。广义的则指那些凡是在老年期见到的各种痴呆的总称,即包括那些在老年期以前就已经发病而又持续至老年期的各种疾病所致的痴呆。根据现有的病因学和病理学认识,老年期痴呆可分为以下三类:①Alzheimer型老年性痴呆(Sennile dementia of Alzheimertype SDAT),本症包括既往的老年性痴呆与Alzheimer型早老性痴呆,它们具有相同的临床症象与病理改变,为最常见的老年痴呆。展开更多
Hyperglycemia- induced unilateral basal ganglion lesions occur mostly in Asian patients. A signal abnormality in the basal ganglion region is evident on these patients’ neuroimaging. Despite characteristic imaging fi...Hyperglycemia- induced unilateral basal ganglion lesions occur mostly in Asian patients. A signal abnormality in the basal ganglion region is evident on these patients’ neuroimaging. Despite characteristic imaging findings and clinical manifestations, the underlying mechanism is still unclear. To clarify the underlying pathophysiology of unilateral basal ganglion lesions, we examined the [18F]- fluorodeoxyglucose (FDG) positron emission tomography (PET) findings in 3 patients with hyperglycemia. The PET studies were performed at 3 weeks, 5 weeks, and 7 months after clinical onset. The markedly reduced rates of cerebral glucose metabolism in the corresponding lesions on T1- weighted magnetic resonance images provided direct evidence of regional metabolic failure. We suggest that the metabolic derangements associated with hyperglycemia and vascular insufficiency contribute to regional metabolic failure in patients with poorly controlled diabetes mellitus.展开更多
文摘老年期痴呆有广义与狭义的两种概念。狭义仅指在老年期(60岁以后)开始发病的痴呆。广义的则指那些凡是在老年期见到的各种痴呆的总称,即包括那些在老年期以前就已经发病而又持续至老年期的各种疾病所致的痴呆。根据现有的病因学和病理学认识,老年期痴呆可分为以下三类:①Alzheimer型老年性痴呆(Sennile dementia of Alzheimertype SDAT),本症包括既往的老年性痴呆与Alzheimer型早老性痴呆,它们具有相同的临床症象与病理改变,为最常见的老年痴呆。
文摘Hyperglycemia- induced unilateral basal ganglion lesions occur mostly in Asian patients. A signal abnormality in the basal ganglion region is evident on these patients’ neuroimaging. Despite characteristic imaging findings and clinical manifestations, the underlying mechanism is still unclear. To clarify the underlying pathophysiology of unilateral basal ganglion lesions, we examined the [18F]- fluorodeoxyglucose (FDG) positron emission tomography (PET) findings in 3 patients with hyperglycemia. The PET studies were performed at 3 weeks, 5 weeks, and 7 months after clinical onset. The markedly reduced rates of cerebral glucose metabolism in the corresponding lesions on T1- weighted magnetic resonance images provided direct evidence of regional metabolic failure. We suggest that the metabolic derangements associated with hyperglycemia and vascular insufficiency contribute to regional metabolic failure in patients with poorly controlled diabetes mellitus.
