Objective: The aim of the study was to investigate the expression differences of serum prealbumin in patients with benign and malignant colorectal tumors and its clinical significance. Methods: The concentrations of t...Objective: The aim of the study was to investigate the expression differences of serum prealbumin in patients with benign and malignant colorectal tumors and its clinical significance. Methods: The concentrations of total protein, albumin, prealbumin, hemoglobin of 113 colorectal cancer patients(cancer group) and 87 colorectal adenomas(adenoma group) were tested in Yixing Hospital Affiliated to Jiangsu University(China) during August 2013 to December 2013. Then the differences between the two groups were compared. Results: In colorectal cancer patients, the concentrations of serum prealbumin in 39/113 cases, total protein in 16/113 cases, albumin in 38/113, hemoglobin in 32/113 were lower than normal ranges. While, in colorectal adenoma patients, the concentrations of serum prealbumin in 4/87 cases, total protein in 2/87, albumin in 1/87, hemoglobin in 2/87 were below the detection limit. Comparative analysis showed that, average expression levels of serum prealbumin, albumin, total protein, hemoglobin in colorectal cancer patients were lower than those of colorectal adenoma patients, the difference was statistically significant(P < 0.05), and colorectal cancer patients were more likely to have lower levels of above indicators(P < 0.05). Conclusion: Compared to colorectal adenoma patients, patients with colorectal cancer have lower average expression levels, and were easier to have lower expression levels of serum albumin, albumin, total protein and hemoglobin, which suggest that colorectal cancer patients are more likely to have metabolic change, and clinic notable.展开更多
文摘为探究真空冷冻干燥(vacuum freeze-drying, FD)、喷雾干燥(spray-drying, SD)和微波真空冷冻干燥(microwave vacuum freeze-drying, MFD)3种干燥方式对蛋清蛋白的差异,利用iTRAQ技术对三者进行蛋白质组差异分析,在得到的157种具有定量信息的蛋清蛋白中,鉴定出87种差异蛋白。MFD vs FD组上调蛋白质数量为46个,占差异蛋白质总数的67.6%。KEGG富集显示,MFD vs FD组和MFD vs SD共有2个基因通路显著富集,分别为折叠和降解、运输和分解代谢。此外,在差异蛋白中筛选出4种蛋白质在干燥过程中丰度变化显著,分别为黏蛋白、血清白蛋白、卵清蛋白相关蛋白Y亚型X1和卵白蛋白相关蛋白Y。该研究首次采用蛋白质组学的方法分析不同干燥方式处理后的鸡蛋清差异蛋白的表达变化,为今后生产和开发高品质蛋清粉及功能性蛋制品提供参考依据。
文摘Objective: The aim of the study was to investigate the expression differences of serum prealbumin in patients with benign and malignant colorectal tumors and its clinical significance. Methods: The concentrations of total protein, albumin, prealbumin, hemoglobin of 113 colorectal cancer patients(cancer group) and 87 colorectal adenomas(adenoma group) were tested in Yixing Hospital Affiliated to Jiangsu University(China) during August 2013 to December 2013. Then the differences between the two groups were compared. Results: In colorectal cancer patients, the concentrations of serum prealbumin in 39/113 cases, total protein in 16/113 cases, albumin in 38/113, hemoglobin in 32/113 were lower than normal ranges. While, in colorectal adenoma patients, the concentrations of serum prealbumin in 4/87 cases, total protein in 2/87, albumin in 1/87, hemoglobin in 2/87 were below the detection limit. Comparative analysis showed that, average expression levels of serum prealbumin, albumin, total protein, hemoglobin in colorectal cancer patients were lower than those of colorectal adenoma patients, the difference was statistically significant(P < 0.05), and colorectal cancer patients were more likely to have lower levels of above indicators(P < 0.05). Conclusion: Compared to colorectal adenoma patients, patients with colorectal cancer have lower average expression levels, and were easier to have lower expression levels of serum albumin, albumin, total protein and hemoglobin, which suggest that colorectal cancer patients are more likely to have metabolic change, and clinic notable.
