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蛋白质序列图形变换及其相似性聚类分析 被引量:1
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作者 潘以红 钱东 朱平 《生命科学研究》 CAS CSCD 2018年第3期191-200,228,共11页
基于氨基酸的疏水性和相对分子质量,先把20种氨基酸分为8类,按不同间隔角度放置于圆周上。根据z轴坐标的划分,建立一个坐标空间。将蛋白质序列中的氨基酸按排列顺序映射到空间坐标系中,得到序列的3D模型。将3D模型转换为20维矩阵图,分... 基于氨基酸的疏水性和相对分子质量,先把20种氨基酸分为8类,按不同间隔角度放置于圆周上。根据z轴坐标的划分,建立一个坐标空间。将蛋白质序列中的氨基酸按排列顺序映射到空间坐标系中,得到序列的3D模型。将3D模型转换为20维矩阵图,分析序列中氨基酸对数量特征及相似性。进一步将空间坐标转换为数值序列,进行离散傅里叶变换(discrete Fourier transform,DFT),得到原蛋白质序列的功率谱,将不同长度的功率谱扩展到数据集中最长序列的长度m维。再通过计算功率谱序列间的欧氏距离来度量序列相似性,构建系统发育树。最后对不同数据集进行验证,结果显示:聚类结果与矩阵图的分析相符,且优于其他算法的效果,表明此算法对蛋白质相似性研究具有一定的有效性。 展开更多
关键词 蛋白质序列图形化 蛋白质序列数值化 矩阵图差异分析 离散傅里叶变换(DFT) 系统发育树
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A new 2D graphical representation of protein sequence and its application
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作者 Lei Wang Hui Peng +1 位作者 Jinhua Zheng Yanzi Qiu 《International Journal of Biomathematics》 2015年第5期201-213,共13页
Graphical representation is a very efficient tool for visual analysis of protein sequences. In this paper, a novel 2D graphical representation scheme is proposed on the basis of a newly introduced concept, named chara... Graphical representation is a very efficient tool for visual analysis of protein sequences. In this paper, a novel 2D graphical representation scheme is proposed on the basis of a newly introduced concept, named characteristic model of the protein sequences. After obtaining the 2D graphics of protein sequences, two numerical characterizations of them is designed as descriptors to analyze the nine DN5 protein sequences, simulation and analysis results show that, comparing with existing methods, our method is not only visible, intuitional, and simple, but also has no circuit or degeneracy, and even more important, since the storage space required by our method is constant and has nothing to do with the length of protein sequences, then it can keep excellent visual inspection for long protein sequences. 展开更多
关键词 2D graphical representation protein sequence similarity/dissimilarity ana-lysis characteristic model visual analysis.
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