Classical methyl-CpG binding proteins contain the conserved DNA binding motif methyl-cytosine binding domain(MBD), which preferentially binds to methylated CpG dinucleotides. These proteins serve as transcriptional re...Classical methyl-CpG binding proteins contain the conserved DNA binding motif methyl-cytosine binding domain(MBD), which preferentially binds to methylated CpG dinucleotides. These proteins serve as transcriptional repressors,mediating gene silencing via DNA cytosine methylation. Mutations in methyl-CpG binding protein 2 (MeCP2) have beenlinked to the human mental retardation disorder Rett syndrome, suggesting an important role for methyl-CpG bindingproteins in brain development and function. This mini-review summarizes the recent advances in studying the diversefunctions of MeCP2 as a prototype for other methyl-CpG binding proteins in the development and function of thevertebrate nervous system.展开更多
文摘Classical methyl-CpG binding proteins contain the conserved DNA binding motif methyl-cytosine binding domain(MBD), which preferentially binds to methylated CpG dinucleotides. These proteins serve as transcriptional repressors,mediating gene silencing via DNA cytosine methylation. Mutations in methyl-CpG binding protein 2 (MeCP2) have beenlinked to the human mental retardation disorder Rett syndrome, suggesting an important role for methyl-CpG bindingproteins in brain development and function. This mini-review summarizes the recent advances in studying the diversefunctions of MeCP2 as a prototype for other methyl-CpG binding proteins in the development and function of thevertebrate nervous system.
