Insulin resistance and dysregulated lipid meta- bolism are major causes of type 2 diabetes. Insulin and inflam- matory signal pathways play key roles in insulin resistance and fat accumulation. Specifically, adapter p...Insulin resistance and dysregulated lipid meta- bolism are major causes of type 2 diabetes. Insulin and inflam- matory signal pathways play key roles in insulin resistance and fat accumulation. Specifically, adapter proteins transduce sig- nals from insulin or cytokine receptors to the downstream pathways and may contribute to insulin resistance and disor- dered lipid metabolism in obesity and type 2 diabetes. Here, the recent advances in understanding the roles of adapter proteins in insulin resistance and lipid homeostasis are discussed.展开更多
基金Acknowledgements This work was supported by the Changbai Mountain Scholars Program of Jilin Province 2013046 （to Z. C.）, the Jilin Talent Development Foundation 111860000 （to Z. C.）, the National Natural Science Foundation of China Grant 31500957 （to Z. C.）, and the startup funds from Northeast Normal University 120401204 （to Z. C.）. I thank Dr. Mark J. Canet （University of Michigan） for editing this manuscript. I also thank lab members （Xinzhi Li, Wangshu Qin, Linna Jia, Sha Li, Xiaomeng Ren, Xue Dong, and Jiana Liu） at Northeast Normal University for helpful discussion. I apologize to colleagues whose relevant work could not be cited here due to space limitation.
文摘Insulin resistance and dysregulated lipid meta- bolism are major causes of type 2 diabetes. Insulin and inflam- matory signal pathways play key roles in insulin resistance and fat accumulation. Specifically, adapter proteins transduce sig- nals from insulin or cytokine receptors to the downstream pathways and may contribute to insulin resistance and disor- dered lipid metabolism in obesity and type 2 diabetes. Here, the recent advances in understanding the roles of adapter proteins in insulin resistance and lipid homeostasis are discussed.
