靶向治疗已成为当今肿瘤研究领域的热点。抗体-药物偶联物(antibody drug conjugates,ADC)兼具抗体的高特异性和细胞毒药物对肿瘤的高毒性,代表了新一代抗体技术的发展方向。ADC由"弹头"药物(细胞毒药物)、抗体以及偶联抗体...靶向治疗已成为当今肿瘤研究领域的热点。抗体-药物偶联物(antibody drug conjugates,ADC)兼具抗体的高特异性和细胞毒药物对肿瘤的高毒性,代表了新一代抗体技术的发展方向。ADC由"弹头"药物(细胞毒药物)、抗体以及偶联抗体和药物的偶联链3部分组成。ADC利用抗体作为载体将"弹头"药物送至靶部位,并通过细胞内吞效应进入溶酶体,释放出细胞毒性药物,从而达到专一性杀死癌细胞而不损伤正常组织细胞的作用。本文综述近年来ADC研制和发展趋势,并探讨ADC研发过程中的几个可能的关键影响因素。展开更多
The coordination polymer of [Mn(p-CPOA)(H2O)3]n (p-CPOA=4-carboxylphenoxyacetate) was synthesized and characterized by elemental analysis, IR, X-ray single crystal diffraction. The title complex crystallizes in mono-c...The coordination polymer of [Mn(p-CPOA)(H2O)3]n (p-CPOA=4-carboxylphenoxyacetate) was synthesized and characterized by elemental analysis, IR, X-ray single crystal diffraction. The title complex crystallizes in mono-clinic with space group P21/c, a=0.699 8(1) nm, b=1.623 5(3) nm, c=1.014 3(2) nm, β=99.55(3)°. V=1.136 5(4) nm3, Z=4, Dc=1.772 g·cm-3, μ=1.193 mm-1, F(000)=620, R=0.026 8, wR=0.074 5. The manganese atom is seven-coordinate involving four oxygen atoms of different p-CPOA2- ligands and three coordinated water, forming a distorted pentagonal bipyramindal environment. Two manganese atoms are bridged by p-CPOA2- ligand, forming a one-dimensional zigzag chain structure along b axis. The adjacent distance of Mn...Mn atoms is 1.021 0 nm. The three-dimensional hydrogen bonding network was formed by the intermolecular hydrogen bonds. CCDC: 219358.展开更多
文摘靶向治疗已成为当今肿瘤研究领域的热点。抗体-药物偶联物(antibody drug conjugates,ADC)兼具抗体的高特异性和细胞毒药物对肿瘤的高毒性,代表了新一代抗体技术的发展方向。ADC由"弹头"药物(细胞毒药物)、抗体以及偶联抗体和药物的偶联链3部分组成。ADC利用抗体作为载体将"弹头"药物送至靶部位,并通过细胞内吞效应进入溶酶体,释放出细胞毒性药物,从而达到专一性杀死癌细胞而不损伤正常组织细胞的作用。本文综述近年来ADC研制和发展趋势,并探讨ADC研发过程中的几个可能的关键影响因素。
文摘The coordination polymer of [Mn(p-CPOA)(H2O)3]n (p-CPOA=4-carboxylphenoxyacetate) was synthesized and characterized by elemental analysis, IR, X-ray single crystal diffraction. The title complex crystallizes in mono-clinic with space group P21/c, a=0.699 8(1) nm, b=1.623 5(3) nm, c=1.014 3(2) nm, β=99.55(3)°. V=1.136 5(4) nm3, Z=4, Dc=1.772 g·cm-3, μ=1.193 mm-1, F(000)=620, R=0.026 8, wR=0.074 5. The manganese atom is seven-coordinate involving four oxygen atoms of different p-CPOA2- ligands and three coordinated water, forming a distorted pentagonal bipyramindal environment. Two manganese atoms are bridged by p-CPOA2- ligand, forming a one-dimensional zigzag chain structure along b axis. The adjacent distance of Mn...Mn atoms is 1.021 0 nm. The three-dimensional hydrogen bonding network was formed by the intermolecular hydrogen bonds. CCDC: 219358.
